Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat

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BACKGROUND: Cancer-induced bone pain remains a serious public health concern, with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition. Burrowing is an innate, ethologically relevant rodent behaviour that has been proven sensitive to chronic pain conditions. Herein, we studied for the first time whether burrowing performance is altered in preclinical models of cancer-induced bone pain.

MATERIALS AND METHODS: Mice and rats were inoculated with syngeneic breast cancer cells. Bone degradation was radiographically evaluated and nociception was assessed in limb-use and burrowing tests.

RESULTS: Cancer-bearing rodents showed reduced relative bone density and limb-use scores, confirming disease development. Burrowing performance decreased over time in both rodent models.

CONCLUSION: Burrowing performance was reduced in both rodent models, indicating that the burrowing test is a relevant and reproducible behavioural test for assessing disease development in both mouse and rat models of cancer-induced bone pain.

Original languageEnglish
JournalIn Vivo
Volume33
Issue number4
Pages (from-to)1125-1132
Number of pages8
ISSN0258-851X
DOIs
Publication statusPublished - 2019

    Research areas

  • Animals, Behavior, Animal, Bone Neoplasms/complications, Cancer Pain/diagnosis, Case-Control Studies, Disease Models, Animal, Male, Mice, Pain Measurement/methods, Rats

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