Kristian Strømgaard
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- 2024
- Published
Investigation of imaging the somatostatin receptor by opening the blood-brain barrier with melittin – A feasibility study using positron emission tomography and [64Cu]Cu-DOTATATE
Andersen, Ida Vang, Bidesi, N. S. R., Shalgunov, Vladimir, Jørgensen, Jesper Tranekjær, Gustavsson, Karl Tobias, Strømgaard, Kristian, Ingemann Jensen, A. T., Kjær, Andreas & Herth, Matthias Manfred, 2024, In: Nuclear Medicine and Biology. 132-133, 5 p., 108905.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Apuschkin, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, , 2024, In: Science Advances. 10, 9, 20 p., eadg2636.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling
Alexopoulou, Flora, Buch-Månson, N., Pedersen, S. L., Vrang, N., Fink, L. N. & Strømgaard, Kristian, 2023, In: Peptides. 168, 7 p., 171063.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction
Balboa, J. R., Essig, D. J., Ma, S., Karer, N., Clemmensen, L. S., Pedersen, S. W., Joerger, A. C., Knapp, S., Østergaard, S. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 976-990Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2
Bartling, Christian Reinhard Otto, Alexopoulou, Flora, Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaité, Vita, Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, Kasper, Gloriam, David E., Mobli, M. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tight control of the APP-Mint1 interaction in regulating amyloid production
Henry, S. M., Kistler, S. A., Lagani, G. D., Bartling, Christian Reinhard Otto, Özcelik, D., Sereikaité, Vita, Strømgaard, Kristian, Beffert, U. & Ho, A., 2023, In: Brain Research. 1817, 6 p., 148496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR
Kuschert, S., Stroet, M., Chin, Y. K. Y., Conibear, A. C., Jia, X., Lee, T., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, P., Rosengren, K. J., Mark, A. E. & Mobli, M., 2023, In: Magnetic Resonance. 4, 1, p. 57-72Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity
Rem, P. D., Sereikaité, Vita, Fernandez-Fernandez, D., Reinartz, S., Ulrich, D., Fritzius, T., Trovò, L., Roux, S., Chen, Ziyang, Rondard, P., Pin, J. P., Schwenk, J., Fakler, B., Gassmann, M., Barkat, T. R., Strømgaard, Kristian & Bettler, B., 2023, In: eLife. 12, 26 p., e82082.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation
Sønderby, T. V., Louros, N. N., Khodaparast, L., Khodaparast, L., Madsen, D. J., Olsen, W. P., Moonen, N., Nagaraj, M., Sereikaité, Vita, Strømgaard, Kristian, Rousseau, F., Schymkowitz, J. & Otzen, D. E., 2023, In: Journal of Molecular Biology. 435, 11, 168039.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
Voss, J. H., Crüsemann, M., Bartling, Christian Reinhard Otto, Kehraus, S., Inoue, A., König, G. M., Strømgaard, Kristian & Müller, C. E., 2023, In: iScience. 26, 4, 19 p., 106492.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**
Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners
Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Lindqvist, R., Benz, C., Sereikaité, Vita, Maassen, L., Laursen, L., Jemth, P., Strømgaard, Kristian, Ivarsson, Y. & Overby, A. K., 2022, In: Viruses. 14, 10, 12 p., 2202.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaité, Vita, Gupta, A., Strømgaard, Kristian, Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E., 2022, In: Journal of Biological Chemistry. 298, 12, 14 p., 102688.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme**
Rajabi, N., Hansen, T. N., Nielsen, A. L., Nguyen, H. T., Bæk, M., Bolding, J. E., Bahlke, O., Petersen, S. E. G., Bartling, Christian Reinhard Otto, Strømgaard, Kristian & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 22, 9 p., e202115805.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation
Bartling, Christian Reinhard Otto, Jensen, T. M. T., Henry, S. M., Colliander, A. L., Sereikaité, Vita, Wenzler, M., Jain, P., Maric, H. M., Harpsøe, Kasper, Pedersen, S. W., Clemmensen, L. S., Haugaard-Kedström, L. M., Gloriam, David E., Ho, A. & Strømgaard, Kristian, 2021, In: Journal of the American Chemical Society. 143, 2, p. 891-901Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of Peptide-Based PDZ Domain Inhibitors
Essig, D. J., Balboa, J. R. & Strømgaard, Kristian, 2021, Methods in Molecular Biology. J-P. B. (ed.). Humana Press, p. 157-177 21 p. (Methods in Molecular Biology, Vol. 2256).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma
Haugaard-Kedstrom, L. M., Clemmensen, L. S., Sereikaite, V., Jin, Z., Fernandes, E. F. A., Wind, B., Abalde-Gil, F., Daberger, J., Vistrup-Parry, M., Aguilar-Morante, D., Leblanc, R., Egea-Jimenez, A. L., Albrigtsen, M., Jensen, K. E., Jensen, T. M. T., Ivarsson, Y., Vincentelli, R., Hamerlik, P., Andersen, J. H., Zimmermann, P. & 2 others, , 2021, In: Journal of Medicinal Chemistry. 64, 3, p. 1423-1434 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain
Jensen, T. M. T., Bartling, Christian Reinhard Otto, Karlsson, O. A., Åberg, E., Haugaard-Kedström, L. M., Strømgaard, Kristian & Jemth, P., 2021, In: ACS chemical biology. 16, 7, p. 1191-1200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical Synthesis of PDZ Domains
Kossmann, C., Ma, S., Clemmensen, L. S. & Strømgaard, Kristian, 2021, Methods in Molecular Biology. J-P. B. (ed.). Humana Press, p. 193-216 24 p. (Methods in Molecular Biology, Vol. 2256).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus
Najarzadeh, Z., Zaman, M., Sereikaité, Vita, Strømgaard, Kristian, Andreasen, M. & Otzen, D. E., 2021, In: Journal of Biological Chemistry. 297, 2, 14 p., 100953.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus
Najarzadeh, Z., Nielsen, J., Farzadfard, A., Sereikaité, Vita, Strømgaard, Kristian, Meyer, R. L. & Otzen, D. E., 2021, In: ACS Omega. 6, 34, p. 21960-21970Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport
Vistrup-Parry, M., Sneddon, W. B., Bach, S., Strømgaard, Kristian, Friedman, P. A. & Mamonova, T., 2021, In: Journal of Biological Chemistry. 296, 12 p., 100473.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation
Vistrup-Parry, M., Chen, X., Johansen, T. L., Bach, S., Buch-Larsen, Sara Charlotte, Bartling, Christian Reinhard Otto, Ma, C., Clemmensen, L. S., Nielsen, Michael Lund, Zhang, M. & Strømgaard, Kristian, 2021, In: iScience. 24, 11, 103268.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction
Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582AResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Mechanism and site of action of big dynorphin on ASIC1a
Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, , 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effects of Lipidation on a TAT-Containing Peptide-Based Inhibitor of PSD-95
Alves Fernandes, Eduardo Felipe, Haugaard-Kedstroem, L. M. & Strømgaard, Kristian, 2020, In: Australian Journal of Chemistry. 73, 4, p. 307-311 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition
Langlhofer, G., Schaefer, N., Maric, H. M., Keramidas, A., Zhang, Y., Baumann, P., Blum, R., Breitinger, U., Strømgaard, Kristian, Schlosser, A., Kessels, M. M., Koch, D., Qualmann, B., Breitinger, H. G., Lynch, J. W. & Villmann, C., 2020, In: Journal of Neuroscience. 40, 25, p. 4954-4969 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery
Li, J., Ge, Y., Huang, J., Strømgaard, Kristian, Zhang, X. & Xiong, X., 2020, In: Journal of Medicinal Chemistry. 63, 10, p. 5013-5030 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-Specific Phosphorylation of PDZ Domains
Ma, S., Strømgaard, Kristian & Clemmensen, L. S., 2020, Expressed Protein Ligation: Methods and Protocols. M. V-P. (ed.). Humana Press, p. 235-261 27 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2133).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Targeting receptor complexes: a new dimension in drug discovery
Rosenbaum, M. I., Clemmensen, L. S., Bredt, D. S., Bettler, B. & Strømgaard, Kristian, 2020, In: Nature Reviews. Drug Discovery. 19, p. 884-901 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein
Toto, A., Ma, S., Malagrinò, F., Visconti, L., Pagano, L., Strømgaard, Kristian & Gianni, S., 2020, In: Protein Science. 29, 10, p. 2038-2042 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent achievements in developing selective Gq inhibitors
Zhang, H., Nielsen, A. L. & Strømgaard, Kristian, 2020, In: Medicinal Research Reviews. 40, 1, p. 135-157Research output: Contribution to journal › Review › Research › peer-review
- 2019
- Published
Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor
Bach, Anders, Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, Henrik, Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, Kristian, May 2019, In: Neuropharmacology. 150, p. 100-111 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PDZ Domains as Drug Targets
Christensen, N. R., Čalyševa, J., Alves Fernandes, Eduardo Felipe, Lüchow, S., Clemmensen, L. S., Haugaard-Kedström, L. M. & Strømgaard, Kristian, 2019, In: Advanced Therapeutics. 2, 7, p. 1800143 1800143.Research output: Contribution to journal › Review › Research › peer-review
- Published
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
Malfacini, D., Patt, J., Annala, S., Harpsøe, Kasper, Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, David E., Bräuner, Hans, Strømgaard, Kristian, König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In: The Journal of Biological Chemistry. 294, 15, p. 5747-5758Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, Kristian, Meisl, G., Sutherland, D., Pedersen, J. S. & Otzen, D. E., 2019, In: Biomolecules. 9, 11, 21 p., 659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities
Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting the gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABA(B) Receptor Protein-Protein Interaction
Sereikaité, Vita, Fritzius, T., Kasaragod, V. B., Bader, N., Maric, H. M., Schindelin, H., Bettler, B. & Strømgaard, Kristian, 2019, In: Journal of Medicinal Chemistry. 62, 19, p. 8819-8830Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890
Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, Apr 2019, In: ChemMedChem. 14, 8, p. 865-870Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms
Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, Kristian, Bryers, J. D., Daggett, V., Meyer, R. L. & Otzen, D. E., 2018, In: Journal of Molecular Biology. 430, 20, p. 3751-3763 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Modulation of Acid-Sensing Ion Channels
Borg, C. B., Haugaard-Kedstrom, L. M., Lynagh, T., Strømgaard, Kristian & Pless, Stephan, 2 Feb 2018, p. 130A-130A.Research output: Contribution to conference › Poster › Research
- Published
Prevention of glutamate-induced retinal ganglion cell death by UCCB01-144 treatment
Bulli, G., Vohra, Rupali, Skytt, D. M., Strømgaard, Kristian & Kolko, Miriam, 2018, In: Acta Ophthalmologica. 96, S261, p. 17-17 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease
Jensen, T. M. T., Albertsen, L., Bartling, Christian Reinhard Otto, Haugaard-kedström, L. M. & Strømgaard, Kristian, 2018, In: ChemBioChem. 19, 11, p. 1119-1122 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers
Norager, N. G., Poulsen, Mette Homann & Strømgaard, Kristian, 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 8048-8053Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations
Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145Research output: Contribution to journal › Review › Research › peer-review
- Published
Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359
Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, Kasper, Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner, Hans, Gloriam, David E. & Strømgaard, Kristian, 2018, In: European Journal of Medicinal Chemistry. 156, p. 847-860Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels
Borg, C. B., Lynagh, T., Haugaard-Kedstrom, L. M., Strømgaard, Kristian & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 420A-420AResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Targeting PSD-95 as a Novel Approach in the Treatment of Stroke
Haugaard-Kedstrom, L. M., Fernandes, E. F. A. & Strømgaard, Kristian, 2017, Neuroprotective Therapy for Stroke and Ischemic Disease . Springer, p. 157-184 28 p. (Springer Series in Translational Stroke Research).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression
Kucharz, Krzysztof, Søndergaard Rasmussen, I., Bach, Anders, Strømgaard, Kristian & Lauritzen, Martin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 5, p. 1820-1828Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission
Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M. & Strømgaard, Kristian, 2017, In: Nature Chemical Biology. 13, p. 153-160 11 p., 2246.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions
Pedersen, S. W., Albertsen, L., Moran, G. E., Levesque, B., Pedersen, S. B., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., Bowen, M. E. & Strømgaard, Kristian, 15 Sep 2017, In: ACS chemical biology. 12, 9, p. 2313-2323 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers
Rannversson, H., Andersen, J., Bang-Andersen, B. & Strømgaard, Kristian, 20 Oct 2017, In: ACS chemical biology. 12, 10, p. 2558-2562 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors
Roszko, K. L., Bi, R., Gorvin, C. M., Bräuner, Hans, Xiong, X., Inoue, A., Thakker, R. V., Strømgaard, Kristian, Gardella, T. & Mannstadt, M., 9 Feb 2017, In: JCI insight. 2, 3, 15 p., e91079.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 20 Jan 2017, In: European Journal of Neuroscience. 45, 2, p. 238-248 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein
Zhang, H., Xiong, X., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, 7 Jun 2017, In: ChemMedChem. 12, 11, p. 830-834 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands
Andersen, J., Ladefoged, L. K., Kristensen, T. N. B., Munro, L., Grouleff, J., Stuhr-Hansen, N., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 19 Oct 2016, In: A C S Chemical Neuroscience. 7, 10, p. 1406-1417 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function
Andreasen T., Jesper, Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In: European Journal of Pharmacology. 780, p. 166-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor
Bach, Anders, Pedersen, T. B. & Strømgaard, Kristian, 2016, In: MedChemComm. 7, 3, p. 531-536 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling
Cheng, J., Sahani, S., Hausrat, T. J., Yang, J-W., Ji, H., Schmarowski, N., Endle, H., Liu, X., Li, Y., Böttche, R., Radyushkin, K., Maric, H. M., Hoerder-Suabedissen, A., Molnár, Z., Prouvot, P-H., Trimbuch, T., Ninnemann, O., Huai, J., Fan, W., Visentin, B. & 7 others, , 5 Oct 2016, In: Neuron. 92, 1, p. 126-142 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis
Pedersen, S. W., Moran, G. E., Sereikaité, Vita, Kedström, L. M. H. & Strømgaard, Kristian, 17 Oct 2016, In: ChemBioChem. 17, 20, p. 1936-1944 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
Rannversson, H., Andersen, J., Hall, L. S., Bang-Andersen, B., Park, M., Huber, T., Sakmar, T. P. & Strømgaard, Kristian, 19 Apr 2016, In: Nature Communications. 7, p. 1-9 9 p., 11261.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of symmetrical and non-symmetrical bivalent neurotransmitter ligands
Stuhr-Hansen, N., Andersen, J., Thygesen, Mikkel Boas & Strømgaard, Kristian, 2016, In: ChemistrySelect. 1, 3, p. 407-413 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding to the PDZ domains of postsynaptic density protein 95
Toto, A., Pedersen, S. W., Karlsson, O. A., Moran, G. E., Andersson, E., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., May 2016, In: Protein Engineering Design and Selection (Print). 29, 5, p. 169-75 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors
Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner, Hans & Strømgaard, Kristian, 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter
Andersen, J., Ladefoged, L. K., Wang, D., Kristensen, T. N. B., Bang-Andersen, B., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 18 Nov 2015, In: A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter
Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, Kristian & Kristensen, Anders Skov, 2015, In: Scientific Reports. 5, p. 1-12 12 p., 15650.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95
Eildal, J. N. N., Bach, Anders, Dogan, J., Ye, F., Zhang, M., Jemth, P. & Strømgaard, Kristian, 2015, In: ChemBioChem. 16, p. 64–69 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors
Maric, H., Kasaragod, V. B., Kedström, L. M. H., Hausrat, T. J., Kneussel, M., Schindelin, H. & Strømgaard, Kristian, 7 Jan 2015, In: Angewandte Chemie (International ed. in English). 54, 2, p. 490-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor
Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family
Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, Anders Skov, Bach, Anders, Jemth, P. & Strømgaard, Kristian, 2015, In: PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding of ArgTX-636 in the NMDA receptor ion channel
Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, Kristian & Kristensen, Anders Skov, 16 Jan 2015, In: Journal of Molecular Biology. 427, 1, p. 176-89 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation
Rannversson, H., Wilson, P., Kristensen, K. B., Sinning, S., Kristensen, Anders Skov, Strømgaard, Kristian & Andersen, J., 5 Jun 2015, In: The Journal of Biological Chemistry. 290, 23, p. 14582-94 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fatty acid derivatives of dimeric inhibitors of PSD-95
Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735Research output: Patent
- Published
Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1
Wilbek, T. S., Skovgaard, T., Sorrell, F. J., Knapp, S., Berthelsen, J. & Strømgaard, Kristian, 2 Jan 2015, In: ChemBioChem. 16, 1, p. 59-63 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyamine toxins from spiders and wasps: Polyamine toxins from spiders and wasps
Xiong, X. & Strømgaard, Kristian, 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, p. 201-214 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2014
- Published
Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac)
Andersen, J., Stuhr-Hansen, N., Zachariassen, L. G., Koldsø, H., Schiøtt, B., Strømgaard, Kristian & Kristensen, Anders Skov, May 2014, In: Molecular Pharmacology. 85, 5, p. 703-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
THE DEVELOPMENT AND CHARACTERIZATION OF A PEPTIDE-BASED SYNTENIN INHIBITOR - IMPLACATIONS FOR CANCER METASTASIS
Haugaard-Kedstrom, L. M., Albertsen, L., Gil, F. A., Ivarsson, Y., Strømgaard, Kristian & Kedström, L. M. H., Sep 2014, In: Journal of Peptide Science. 20, Suppl. 1, p. s39 1 p., YO11.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins
Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.Research output: Contribution to journal › Journal article › Research
- Published
Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin
Maric, H., Kasaragod, V. B., Hausrat, T. J., Kneussel, M., Tretter, V., Strømgaard, Kristian & Schindelin, H., 22 Dec 2014, In: Nature Communications. 5, p. 1-11 11 p., 5767.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors
Nørager, N. G., Poulsen, Mette Homann, Jensen, A. G., Jeppesen, N. S., Kristensen, Anders Skov & Strømgaard, Kristian, 12 Jun 2014, In: Journal of Medicinal Chemistry. 57, 11, p. 4940-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2014, In: Nature Communications. 5, p. 1-11 11 p., 3215.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain
Pedersen, S. W., Hultqvist, G., Strømgaard, Kristian & Jemth, P., 2014, In: PLOS ONE. 9, 4, p. 1-7 7 p., e95619.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin
Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, 22 Feb 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors
Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids
Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines
Stuhr-Hansen, N., Bork, N. & Strømgaard, Kristian, 14 Aug 2014, In: Organic & Biomolecular Chemistry. 12, 30, p. 5745-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites
Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors
Xiong, X., Poulsen, Mette Homann, Hussein, R. A., Nørager, N. G. & Strømgaard, Kristian, Dec 2014, In: ChemMedChem. 9, 12, p. 2661-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
A parallel semisynthetic approach for structure-activity relationship studies of peptide YY
Albertsen, L., Østergaard, S., Paulsson, J. F., Norrild, J. C. & Strømgaard, Kristian, Sep 2013, In: ChemMedChem. 8, 9, p. 1505-13Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications
Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C. & Strømgaard, Kristian, 12 Dec 2013, In: A C S Medicinal Chemistry Letters. 4, 12, p. 1228-1232 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant production of peptide C-terminal α-amides using an engineered intein
Albertsen, L., Shaw, A. C., Norrild, J. C. & Strømgaard, Kristian, 20 Nov 2013, In: Bioconjugate Chemistry. 24, 11, p. 1883-94 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801
Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, J., Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In: Neuropharmacology. 67, p. 193-200 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations
Eildal, J. N. N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, Kristian & Jemth, P., 4 Sep 2013, In: Journal of the American Chemical Society. 135, 35, p. 12998-3007 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy
Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Energetic pathway sampling in a protein interaction domain
Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In: Structure. 21, 7, p. 1193-1202Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons
Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group
Pedersen, S. W., Armishaw, C. J. & Strømgaard, Kristian, 2013, Peptide synthesis and applications. Humana Press, Vol. 1047. p. 65-80 16 p. (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors
Poulsen, Mette Homann, Lucas, S., Bach, T. B., Barslund, A. F., Wenzler, C., Jensen, C. B., Kristensen, Anders Skov & Strømgaard, Kristian, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1171-1181 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters
Stuhr-Hansen, N., Wilbek, T. S. & Strømgaard, Kristian, 1 Aug 2013, In: European Journal of Organic Chemistry. 2013, 24, p. 5290-5294 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic and mechanistic insight into nosylation of glycine residues
Stuhr-Hansen, N., Sølling, Theis Ivan & Strømgaard, Kristian, 14 Apr 2013, In: Organic & Biomolecular Chemistry. 11, 14, p. 2288-2293 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Submitted
High-affinity, dimeric inhibitors of PSD-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain
Bach, Anders & Strømgaard, Kristian, 2012, (Submitted) Patent No. WO2012/156308 (Granted: EP2707014B1; US9139615B2)Research output: Patent
- Published
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding by PDZ domains
Chi, C. N., Bach, Anders, Strømgaard, Kristian, Gianni, S. & Jemth, P., 2012, In: BioFactors. 38, 5, p. 338-348 (Review) 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains
Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In: Journal of the American Chemical Society. 134, 1, p. 599-605Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An expanded view of the protein folding landscape of PDZ domains
Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., 11 May 2012, In: Biochemical and Biophysical Research Communications. 421, 3, p. 550-553 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors
Lucas, S., Poulsen, Mette Homann, Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, Anders Skov & Strømgaard, Kristian, 26 Nov 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A heteromeric snake toxin and the molecular details of pain perception
Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters
Andersen, J., Stuhr-Hansen, N., Zachariassen, L., Toubro, S., Hansen, S. M. R., Eildal, J. N. N., Bond, A. D., Bøgesø, K. P., Bang-Andersen, B., Kristensen, Anders Skov & Strømgaard, Kristian, 19 Jul 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12137-12142Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors
Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expedient synthesis of 1,3-substituted benzene peptidomimetics
Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In: Synthesis. 2011, 5, p. 807-815Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction
Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In: Journal of Medicinal Chemistry. 54, 5, p. 1333-1346Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata
Barslund, A. F., Poulsen, Mette Homann, Bach, T. B., Lucas, S., Kristensen, Anders Skov & Strømgaard, Kristian, 2011, In: Journal of Natural Products. 74, 3, p. 483-486Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97
Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3597-3606Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small molecules from spiders used as chemical probes
Olsen, C. A., Kristensen, Anders Skov & Strømgaard, Kristian, 25 Nov 2011, In: Angewandte Chemie International Edition. 50, 48, p. 11296-11311Research output: Contribution to journal › Review › Research › peer-review
- Published
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Antidepressive lægemidler: nu i 3D
Andersen, J., Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, Dec 2010, In: Lægemiddelforskning. 2010, p. 25-27Research output: Contribution to journal › Journal article › Communication
- Published
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter
Andersen, J., Olsen, L., Hansen, K. B., Taboureau, O., Jørgensen, Flemming Steen, Jørgensen, A. M., Bang-Andersen, B., Egebjerg, J., Strømgaard, Kristian & Kristensen, Anders Skov, 2010, In: Journal of Biological Chemistry. 285, 3, p. 2051-2063Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and absolute configuration of ginkgolide B characterized by IR- and VCD spectroscopy
Andersen, N. H., Christensen, Niels Johan, Lassen, P. R., Freedman, T. B. N., Nafie, L. A., Strømgaard, Kristian & Hemmingsen, Lars Bo Stegeager, 2010, In: Chirality. 22, 2, p. 217-223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modified peptides as potent inhibitors of the PSD-95/NMDA receptor interaction
Bach, Anders & Strømgaard, Kristian, 14 Jan 2010, Patent No. WO2010/004003 (Granted: EP2320927B1; US9241967B2)Research output: Patent
- Published
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example
Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In: Journal of Biological Chemistry. 285, 36, p. 28252-28260Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists
Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In: Journal of Medicinal Chemistry. 53, 20, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Textbook of drug design and discovery
Krogsgaard-Larsen, Povl, Strømgaard, Kristian & Madsen, Ulf, 2010, 4 ed. Boca Raton: CRC Press. 460 p.Research output: Book/Report › Book › Education
- Published
Chemical biology
Strømgaard, Kristian, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 59-74Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Location of the antidepressant binding site in the serotonin transporter: importance of SER-438 in recognition of citalopram and tricyclic antidepressants
Andersen, J., Taboureau, O., Hansen, K. B., Olsen, L., Egebjerg, J., Strømgaard, Kristian & Kristensen, Anders Skov, 2009, In: Journal of Biological Chemistry. 284, 15, p. 10276-10284Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters
Andersen, J., Kristensen, Anders Skov, Bang-Andersen, B. & Strømgaard, Kristian, 2009, In: Chemical Communications. 25, p. 3677-3692Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives
Armishaw, C., Jensen, Anders A., Balle, T., Clark, R. J., Harpsøe, Kasper, Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, In: Journal of Biological Chemistry. 284, 14, p. 9498-9512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological activity of novel a-conotoxin analogues incorporating substituted proline derivatives
Armishaw, C., Jensen, Anders A., Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, Peptides for youth: The proceedings of the 20th American peptide symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). Springer, Vol. 611. p. 179-180 (Advances in Experimental Medicine and Biology, Vol. 611).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction
Bach, Anders, Chi, C. N., Pang, G. F., Olsen, L., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 51, p. 9685-9689Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sequential binding mechanism in a PDZ domain
Chi, C. N., Bach, Anders, Engström, Å., Wang, H., Strømgaard, Kristian, Gianni, S. & Jemth, P., 2009, In: Biochemistry. 48, 30, p. 7089-7097Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction
Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors
Nelson, J. K., Frølund, S. U., Tikhonov, D. B., Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 17, p. 3087-3091Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skræddersyede proteiner: uden naturens begrænsninger
Strømgaard, Kristian, Jensen, M. S. & Kristensen, Anders Skov, 2009, In: Lægemiddelforskning. p. 10-12Research output: Contribution to journal › Journal article › Communication
- 2008
- Published
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction
Bach, Anders, Chi, C. N., Olsen, T. B., Pedersen, S. W., Røder, M. U., Pang, G. F., Clausen, Rasmus Prætorius, Jemth, P. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6450-6459Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-protein interaktion: et nyt mål for udvikling af lægemidler
Bach, Anders, Gottschalk, M., Kristensen, Anders Skov & Strømgaard, Kristian, 2008, In: Lægemiddelforskning. p. 10-12Research output: Contribution to journal › Journal article › Communication
- Published
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies
Eildal, J. N. N., Andersen, J., Kristensen, Anders Skov, Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 10, p. 3045-3048Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors
Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.Research output: Contribution to conference › Poster › Research
- Published
Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling
Strømgaard, Kristian, 2008, In: Carlsbergfondet. Aarsskrift. p. 42-47Research output: Contribution to journal › Journal article › Communication
- 2007
- Published
Probing the pharmacophore of ginkgolides as glycine receptor antagonists
Jensen, Anders A., Begum, N., Vogensen, S. B., Knapp, K. M., Gundertofte, K., Dzyuba, S. V., Ishii, H., Nakanishi, K., Kristiansen, Uffe & Strømgaard, Kristian, 2007, In: Journal of Medicinal Chemistry. 50, 7, p. 1610-1617Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expressed protein ligation of ionotropic glutamate receptors
Jensen, M. S., Kristensen, Anders Skov & Strømgaard, Kristian, 2007, In: Biopolymers. 88, 4, p. 602Research output: Contribution to journal › Conference abstract in journal › Research
- 2006
- Published
Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives
Andersen, T. F., Tikhonov, D. B., Bølcho, U., Bolshakov, K., Nelson, J. K., Pluteanu, F., Mellor, I. R., Egebjerg, J. & Strømgaard, Kristian, 7 Sep 2006, In: Journal of Medicinal Chemistry. 49, 18, p. 5414-5423 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion
Jensen, Anders A. & Strømgaard, Kristian, 2006, In: Dansk Kemi 83. 87, 1, p. 16-18Research output: Contribution to journal › Journal article › Communication
- Published
Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors
Jensen, L. S., Bølcho, U., Egebjerg, J. & Strømgaard, Kristian, Apr 2006, In: ChemMedChem. 1, 4, p. 419-428 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unaturlige aminosyrer skaber ny viden om proteiner
Rannes, J., Andersen, J., Jensen, Anders A., Christensen, L. & Strømgaard, Kristian, 2006, In: Lægemiddelforskning. p. 28-29Research output: Contribution to journal › Journal article › Communication
- Published
Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy
Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist
Andersen, T. F., Vogensen, S. B., Jensen, L. S., Knapp, K. M. & Strømgaard, Kristian, 1 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 17, p. 5104-5112 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural products as tools for studies of ligand-gated ion channels
Strømgaard, Kristian, 2005, In: Chemical Record. 5, 4, p. 229-239 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyamine toxins: development of selective ligands for ionotropic receptors
Strømgaard, Kristian, Jensen, L. S. & Vogensen, S. B., 1 Mar 2005, In: Toxicon. 45, 3, p. 249-254 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Ginkgolides and glycine receptors: a structure-activity relationship study
Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific incorporation of unnatural amino acids into proteins
Strømgaard, A., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: ChemBioChem. 5, 7, p. 909-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins
Strømgaard, Kristian & Mellor, I., Sep 2004, In: Medicinal Research Reviews. 24, 5, p. 589-620 32 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemistry and biology of terpene trilactones from Ginkgo biloba
Strømgaard, Kristian & Nakanishi, K., 19 Mar 2004, In: Angewandte Chemie International Edition. 43, 13, p. 1640-1658 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of a tritiated ginkgolide
Strømgaard, Kristian, Suehiro, M. & Nakanishi, K., 15 Nov 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 22, p. 5673-5675 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of polyamines and polyamine toxins. An improved alkylation procedure
Strømgaard, Kristian & Andersen, T., 2004, In: Tetrahedron Letters. 45, p. 7929-7933Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors
Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In: Molecular Pharmacology. 64, 4, p. 954-964 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
Ivic, L., Sands, T. T. J., Fishkin, N., Nakanishi, K., Kriegstein, A. R. & Strømgaard, Kristian, 5 Dec 2003, In: Journal of Biological Chemistry. 278, 49, p. 49279-49285 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
Mellor, I. R., Brier, T. J., Pluteanu, F., Strømgaard, Kristian, Saghyan, A., Eldursi, N., Brierley, M. J., Andersen, K., Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Jan 2003, In: Neuropharmacology. 44, 1, p. 70-80 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists
Vogensen, S. B., Strømgaard, Kristian, Shindou, H., Jaracz, S., Suehiro, M., Ishii, S., Shimizu, T. & Nakanishi, K., 13 Feb 2003, In: Journal of Medicinal Chemistry. 46, 4, p. 601-608 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Ginkgolides: selective acetylations, translactonization, and biological evaluation
Jaracz, S., Strømgaard, Kristian & Nakanishi, K., 28 Jun 2002, In: Journal of Organic Chemistry. 67, 13, p. 4623-4626 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors
Kromann, H., Krikstolaityte, S., Andersen, A. J., Andersen, K., Krogsgaard-Larsen, Povl, Jaroszewski, J. W., Egebjerg, J. & Strømgaard, Kristian, 19 Dec 2002, In: Journal of Medicinal Chemistry. 45, 26, p. 5745-5754 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation
Strømgaard, Kristian, Saito, D. R., Shindou, H., Ishii, S., Shimizu, T. & Nakanishi, K., 29 Aug 2002, In: Journal of Medicinal Chemistry. 45, 18, p. 4038-4046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist
Strømgaard, Kristian, Mellor, I. R., Andersen, K., Neagoe, I., Pluteanu, F., Usherwood, P. N. R., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 22 Apr 2002, In: Bioorganic & Medicinal Chemistry Letters. 12, 8, p. 1159-1162 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Recent advances in the medicinal chemistry of polyamine toxins
Strømgaard, Kristian, Andersen, K., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Nov 2001, In: Mini - Reviews in Medicinal Chemistry. 1, 4, p. 317-338 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example
Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In: Synthesis. 6, p. 877-884 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12
Strømgaard, Kristian, Bjørnsdottir, I., Andersen, K., Brierley, M. J., Rizoli, S., Eldursi, N., Mellor, I. R., Usherwood, P. N., Hansen, S. H., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Feb 2000, In: Chirality. 12, 2, p. 93-102 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues
Strømgaard, Kristian, Brier, T. J., Andersen, K., Mellor, I. R., Saghyan, A., Tikhonov, D., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Nov 2000, In: Journal of Medicinal Chemistry. 43, 23, p. 4526-4533 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor
Strømgaard, Kristian, Brierley, M. J., Andersen, K., Sløk, F. A., Mellor, I. R., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Dec 1999, In: Journal of Medicinal Chemistry. 42, 25, p. 5224-5234 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
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