Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor
Final published version, 1.54 MB, PDF document
PSD-95 PDZ domains are biologically important and promising drug targets. Here, we discover a triazole-based peptidomimetic, 10, by ‘click chemistry’. Compound 10 inhibits the PDZ2/GluN2B interaction with affinity similar to tripeptide SAV and better than current small-molecules. Thus, 10 represents a new class of PSD-95 PDZ inhibitors.
Original language | English |
---|---|
Journal | MedChemComm |
Volume | 7 |
Issue number | 3 |
Pages (from-to) | 531-536 |
Number of pages | 6 |
ISSN | 2040-2503 |
DOIs | |
Publication status | Published - 2016 |
Number of downloads are based on statistics from Google Scholar and www.ku.dk
No data available
ID: 154053805