ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression

Department of Drug Design and Pharmacology

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. / Rafn, Bo; Nielsen, Christian Friberg; Andersen, Sofie Hagel; Szyniarowski, Piotr; Corcelle-Termeau, Elisabeth; Valo, Erkka; Fehrenbacher, Nicole; Olsen, Charlotta Johanne; Daugaard, Mads; Egebjerg, Christina; Bøttzauw, Trine; Kohonen, Pekka; Nylandsted, Jesper; Hautaniemi, Sampsa; Moreira, José Manuel Alfonso; Jaattela, Marja; Kallunki, Tuula.

In: Molecular Cell, Vol. 45, No. 6, 2012, p. 764-776.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rafn, B, Nielsen, CF, Andersen, SH, Szyniarowski, P, Corcelle-Termeau, E, Valo, E, Fehrenbacher, N, Olsen, CJ, Daugaard, M, Egebjerg, C, Bøttzauw, T, Kohonen, P, Nylandsted, J, Hautaniemi, S, Moreira, JMA, Jaattela, M & Kallunki, T 2012, 'ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression', Molecular Cell, vol. 45, no. 6, pp. 764-776. https://doi.org/10.1016/j.molcel.2012.01.029

APA

Rafn, B., Nielsen, C. F., Andersen, S. H., Szyniarowski, P., Corcelle-Termeau, E., Valo, E., Fehrenbacher, N., Olsen, C. J., Daugaard, M., Egebjerg, C., Bøttzauw, T., Kohonen, P., Nylandsted, J., Hautaniemi, S., Moreira, J. M. A., Jaattela, M., & Kallunki, T. (2012). ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. Molecular Cell, 45(6), 764-776. https://doi.org/10.1016/j.molcel.2012.01.029

Vancouver

Rafn B, Nielsen CF, Andersen SH, Szyniarowski P, Corcelle-Termeau E, Valo E et al. ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. Molecular Cell. 2012;45(6):764-776. https://doi.org/10.1016/j.molcel.2012.01.029

Author

Rafn, Bo ; Nielsen, Christian Friberg ; Andersen, Sofie Hagel ; Szyniarowski, Piotr ; Corcelle-Termeau, Elisabeth ; Valo, Erkka ; Fehrenbacher, Nicole ; Olsen, Charlotta Johanne ; Daugaard, Mads ; Egebjerg, Christina ; Bøttzauw, Trine ; Kohonen, Pekka ; Nylandsted, Jesper ; Hautaniemi, Sampsa ; Moreira, José Manuel Alfonso ; Jaattela, Marja ; Kallunki, Tuula. / ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. In: Molecular Cell. 2012 ; Vol. 45, No. 6. pp. 764-776.

Bibtex

@article{dc2be04b093842bb949534658bca714c,

title = "ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression",

abstract = "Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is largely unknown. We show that cysteine cathepsins B and L are elevated in ErbB2 positive primary human breast cancer and function as effectors of ErbB2-induced invasion in vitro. We identify Cdc42-binding protein kinase beta, extracellular regulated kinase 2, p21-activated protein kinase 4, and protein kinase C alpha as essential mediators of ErbB2-induced cysteine cathepsin expression and breast cancer cell invasiveness. The identified signaling network activates the transcription of cathepsin B gene (CTSB) via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of CTSB. This work provides a model system for ErbB2-induced breast cancer cell invasiveness, reveals a signaling network that is crucial for invasion in vitro, and defines a specific role and targets for the identified serine-threonine kinases.",

author = "Bo Rafn and Nielsen, {Christian Friberg} and Andersen, {Sofie Hagel} and Piotr Szyniarowski and Elisabeth Corcelle-Termeau and Erkka Valo and Nicole Fehrenbacher and Olsen, {Charlotta Johanne} and Mads Daugaard and Christina Egebjerg and Trine B{\o}ttzauw and Pekka Kohonen and Jesper Nylandsted and Sampsa Hautaniemi and Moreira, {Jos{\'e} Manuel Alfonso} and Marja Jaattela and Tuula Kallunki",

year = "2012",

doi = "10.1016/j.molcel.2012.01.029",

language = "English",

volume = "45",

pages = "764--776",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression

AU - Rafn, Bo

AU - Nielsen, Christian Friberg

AU - Andersen, Sofie Hagel

AU - Szyniarowski, Piotr

AU - Corcelle-Termeau, Elisabeth

AU - Valo, Erkka

AU - Fehrenbacher, Nicole

AU - Olsen, Charlotta Johanne

AU - Daugaard, Mads

AU - Egebjerg, Christina

AU - Bøttzauw, Trine

AU - Kohonen, Pekka

AU - Nylandsted, Jesper

AU - Hautaniemi, Sampsa

AU - Moreira, José Manuel Alfonso

AU - Jaattela, Marja

AU - Kallunki, Tuula

PY - 2012

Y1 - 2012

N2 - Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is largely unknown. We show that cysteine cathepsins B and L are elevated in ErbB2 positive primary human breast cancer and function as effectors of ErbB2-induced invasion in vitro. We identify Cdc42-binding protein kinase beta, extracellular regulated kinase 2, p21-activated protein kinase 4, and protein kinase C alpha as essential mediators of ErbB2-induced cysteine cathepsin expression and breast cancer cell invasiveness. The identified signaling network activates the transcription of cathepsin B gene (CTSB) via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of CTSB. This work provides a model system for ErbB2-induced breast cancer cell invasiveness, reveals a signaling network that is crucial for invasion in vitro, and defines a specific role and targets for the identified serine-threonine kinases.

AB - Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is largely unknown. We show that cysteine cathepsins B and L are elevated in ErbB2 positive primary human breast cancer and function as effectors of ErbB2-induced invasion in vitro. We identify Cdc42-binding protein kinase beta, extracellular regulated kinase 2, p21-activated protein kinase 4, and protein kinase C alpha as essential mediators of ErbB2-induced cysteine cathepsin expression and breast cancer cell invasiveness. The identified signaling network activates the transcription of cathepsin B gene (CTSB) via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of CTSB. This work provides a model system for ErbB2-induced breast cancer cell invasiveness, reveals a signaling network that is crucial for invasion in vitro, and defines a specific role and targets for the identified serine-threonine kinases.

U2 - 10.1016/j.molcel.2012.01.029

DO - 10.1016/j.molcel.2012.01.029

M3 - Journal article

C2 - 22464443

VL - 45

SP - 764

EP - 776

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 6

ER -

ID: 44533579