The main focus of the current research in the Frølund group is on GHB/CaMK2 pharmacology and the ionotropic GABA_A receptors but also covers nACh receptors and the GABA relevant transporters GAT and TauT.

The overall goal of the research is to develop molecular probes and novel methodologies to obtain insight into identity, localization, function, therapeutic potential of target receptors/transporters, and to match orphan ligands and binding sites with neuroprotection in focus.

The approaches comprise structure-activity studies, development of imaging ligands for determination of localization, mobility and activation of target proteins, and engineered molecular probes for ligand-protein crystallization, identification and probing of binding sites, bioorthogonal chemistry, targeted delivery and rewiring cell signaling.

All projects are interdisciplinary, building on international and national collaborations. With a platform in medicinal chemistry, our projects bridges with molecular pharmacology, computational and biostructural chemistry.