Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
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Documents
- Perani_et_al-2019-Alzheimer's_&_Dementia__Diagnosis,_Assessment_&_Disease_Monitoring
Final published version, 296 KB, PDF document
Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
Original language | English |
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Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 11 |
Pages (from-to) | 327-332 |
Number of pages | 6 |
ISSN | 2352-8729 |
DOIs | |
Publication status | Published - 1 Dec 2019 |
- Amyloid, Neuroinflammation, PET molecular imaging, Protheinopathies, Radiotracers, Tau
Research areas
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