Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine
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Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine. / Shalgunov, Vladimir; van den Broek, Sara Lopes; Andersen, Ida Vang; Raval, Nakul R.; Schäfer, Gabriela; Barz, Matthias; Herth, Matthias M.; Battisti, Umberto M.
In: Nuclear Medicine and Biology, Vol. 128-129, 108877, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine
AU - Shalgunov, Vladimir
AU - van den Broek, Sara Lopes
AU - Andersen, Ida Vang
AU - Raval, Nakul R.
AU - Schäfer, Gabriela
AU - Barz, Matthias
AU - Herth, Matthias M.
AU - Battisti, Umberto M.
N1 - Funding Information: Stina Syvänen and Dag Sehlin (Uppsala University) are acknowledged for kindly providing the 3D6 antibody and the tg-ArcSwe brain tissue. This project has received funding from the European Union's EU Framework Programme for Research and Innovation Horizon 2020 , under grant agreement no. 668532 . MMH has received funding from the European Union's EU Framework Programme for Research and Innovation Horizon 2020 (grant agreement no. 670261 ). VS was supported by BRIDGE – Translational Excellence Programme at the Faculty of Health and Medical Sciences, University of Copenhagen , funded by the Novo Nordisk Foundation (grant agreement no. NNF18SA0034956 ). The Lundbeck Foundation , the Novo Nordisk Foundation , the Innovation Fund Denmark , and the Research Council for Independent Research (grant agreement no. 8022-00187B ) are further acknowledged. Funding Information: Stina Syvänen and Dag Sehlin (Uppsala University) are acknowledged for kindly providing the 3D6 antibody and the tg-ArcSwe brain tissue. This project has received funding from the European Union's EU Framework Programme for Research and Innovation Horizon 2020, under grant agreement no. 668532. MMH has received funding from the European Union's EU Framework Programme for Research and Innovation Horizon 2020 (grant agreement no. 670261). VS was supported by BRIDGE – Translational Excellence Programme at the Faculty of Health and Medical Sciences, University of Copenhagen, funded by the Novo Nordisk Foundation (grant agreement no. NNF18SA0034956). The Lundbeck Foundation, the Novo Nordisk Foundation, the Innovation Fund Denmark, and the Research Council for Independent Research (grant agreement no. 8022-00187B) are further acknowledged. Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Brain pretargeted nuclear imaging for the diagnosis of various neurodegenerative diseases is a quickly developing field. The tetrazine ligation is currently the most explored approach to achieve this goal due to its remarkable properties. In this work, we evaluated the performance of F-537-Tetrazine, previously developed by Biogen, and N-(3-[18F]fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine, previously developed in our group, thereby allowing for the direct comparison of these two imaging probes. The evaluation included synthesis, radiolabeling and a comparison of the physicochemical properties of the compounds. Furthermore, their performance was evaluated by in vitro and in vivo pretargeting models. This study indicated that N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine might be more suited for brain pretargeted imaging.
AB - Brain pretargeted nuclear imaging for the diagnosis of various neurodegenerative diseases is a quickly developing field. The tetrazine ligation is currently the most explored approach to achieve this goal due to its remarkable properties. In this work, we evaluated the performance of F-537-Tetrazine, previously developed by Biogen, and N-(3-[18F]fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine, previously developed in our group, thereby allowing for the direct comparison of these two imaging probes. The evaluation included synthesis, radiolabeling and a comparison of the physicochemical properties of the compounds. Furthermore, their performance was evaluated by in vitro and in vivo pretargeting models. This study indicated that N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine might be more suited for brain pretargeted imaging.
KW - Blood-brain-barrier
KW - Imaging
KW - Pretargeting
KW - Tetrazine ligation
U2 - 10.1016/j.nucmedbio.2024.108877
DO - 10.1016/j.nucmedbio.2024.108877
M3 - Journal article
C2 - 38232579
AN - SCOPUS:85185494504
VL - 128-129
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
M1 - 108877
ER -
ID: 384247139