Protein-membrane interactions in health and disease in the Galvagnion Group
Our research aims at understanding how changes in protein-lipid interactions can lead to the loss of function and/or the gain of toxicity of proteins in the context of disease.
In particular, we aim at providing mechanistic insights into the interplay between disruptions in lipid homeostasis and neurodegenerative disorders, such as Parkinson's Disease. In order to address this question, we use a multidisciplinary approach at the interface between biology and biophysics including the study of different disease cellular models and the characterization of protein-membrane interactions and aggregation at the molecular level.
1. Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation (Galvagnion C, et al, Brain, 2022)
2. Short chain negatively charged phospholipids initiate α-synuclein aggregation (Galvagnion C, et al, Nat Chem Biol. 2015; Galvagnion C, et al, PNAS 2016)
3. Lipid molecules co-assemble with α-synuclein into amyloid fibrils (Galvagnion C, et al, J Phys Chem Lett. 2019)
2023
DFF project 1
Céline Galvagnion received a DKK 2,879,534 grant from Danmarks Frie Forskningsfond for the project “Understanding the cytotoxicity of protein-lipid aggregates in Parkinson’s Disease”. This project aims to investigate the toxicity of protein-lipid aggregates and fibrils in different cellular models of Parkinson’s Disease.
FEBS Youth travel grant
Jesper Elmsted Dreier received a 695 € travel grant from the Federation of European Biochemical Societies (FEBS) to attend the FEBS Advanced Lecture Course entitled “Protein folding, aggregation and compartmentalization”.
EraPermed project
Céline Galvagnion and her partners received a 1.749.377 € collaborative grant from EraPermed for the project “DEEPEN-iRBD Prodromal DEtErminants for PhENoconversion of idiopathic RBD to alpha-synucleinopathies (PD, DLB and MSA)”. The DEEPEN-iRBD study aims to model the progression of REM sleep behaviour disorder (RBD) towards Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB). The DEEPEN-iRBD study is coordinated by Graziella Cappelletti from the University of Milan and involves partners from Milan Maugeri Clinical Science Institute, the Lund University, the French National Centre for Scientific Research, the Danish Parkinson’s Association and the University of Zagreb. (Twitter; LinkedIn)
2022
Innovation Fund Denmark’s Industrial PhD Fellowship
Céline Galvagnion and her collaborators received a DKK 1,072,000 Industrial PhD grant from Innovation Fund Denmark for the project “LRRK2 modulation of lysosomal function and α-synuclein homeostasis – investigation of how LRRK2 mutations lead to Parkinson’s disease”. The project is coordinated by Tau Benned-Jensen at Lundbeck.
2021
Parkinsonforeningen project grant
Céline Galvagnion received a DKK 145,000 grant from the Danish Parkinson’s disease foundation (Parkinsonforeningen) to continue our work on investigating the interplay between lipid changes and protein aggregation associated with decreases in glucocerebrosidase protein and activity levels in differentiated SH-SY5Y cells.
2020
Novo-Nordisk Foundation Hallas-Møller Emerging Investigator grant
Céline Galvagnion received a DKK 9,978,812 Hallas-Møller Emerging Investigator grant from the Novo-Nordisk Foundation for the project “Brain lipid ageing and selective neuronal vulnerability in the context of Parkinson’s Disease”. This project aims at identifying disruptions in lipid metabolism associated with ageing and Parkinson’s Disease in neuronal cell models and post-mortem brain samples. More information can be found here.
2019
Carlsberg Foundation Young Researcher Fellowship
Céline Galvagnion received a DKK 4,499,587 Young Researcher Fellowship from the Carlsberg Foundation for the project “Establishing the role of Glucocerebrosidase mutations and associated changes in lipid metabolism in the emergence of alpha-synuclein and Parkinson Disease pathology”. This project aims at identifying disruptions in lipid metabolism associated with GBA mutations in neuronal cells and post-mortem brain samples. More information can be found here.
Parkinsonforeningen project grant
Céline Galvagnion received a DKK 100,000 grant from the Danish Parkinson’s disease foundation (Parkinsonforeningen) to start the work on investigating the interplay between lipid changes and protein aggregation associated with decreases in glucocerebrosidase protein and activity levels in differentiated SH-SY5Y cells.
Group members
Name | Title | Phone | |
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Dreier, Jesper Elmsted | PhD Fellow | +4535322043 | |
Galvagnion-Büll, Céline | Associate Professor | +4535337828 | |
Marlet, Frederik Ravnkilde | Postdoc | +4535334982 | |
Schott, Katharina Helga | PhD Fellow | +4535324523 | |
Schøler, Betina Vidtfeldt | Laboratory Technician | +4535325191 | |
Stenstrøm, Krista Stroyer | Research Assistant |
Navn | Titel | |
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Josephine Fussing Tengberg | Industriel PhD student |