Neuromet - Neurometabolism in health and diseases

We study the biochemical and cellular mechanisms underlying energy and amino acid metabolism in the mammalian brain, as well as metabolic brain disorders.





































































Research projects




Decline in cerebral glucose metabolism is well established as one of the early pathogenic markers of Alzheimer’s disease (AD) and a potential initiator of neurodegeneration. Impaired insulin signaling, changes in expression and regulation of key enzymes of glucose metabolism and mitochondrial dysfunction all contribute to this hypometabolism.

In NeuroMet we want to characterize the brain hypometabolism in early AD. How does the reduced glucose metabolism develop and how does it affect the disease progression and the vulnerability of neurons and astrocytes?

We are using novel in-vitro models based on neurons and astrocytes either from patient derived tissue or an AD mouse model. By incubating cell cultures with 13C-labeled substrates and subsequently analyzing tissue extracts using nuclear magnetic resonance spectroscopy (NMRS) and mass spectrometry (MS), we get a detailed mapping of the metabolism in the AD models. Furthermore, by using Seahorse Extracellular Flux Analyzer we are able to monitor oxygen consumption to assess the oxidative capacity in the AD models. To evaluate the vulnerability of the cells we apply different AD stressors.

This project will contribute to validation of the AD models used and pave the way for a novel understanding of the coupling between brain energy metabolism and AD. This may lead to a highly needed new approach in AD treatment.

Projects members

Helle S. Waagepetersen
Professor (Head of unit)
Phone: +45 35 33 64 70

Jakob D. Nissen
Blanca Irene Aldana Garcia
Sofie K. Christensen
Jens V. Andersen


  • Heikki Tanila, Uni. Eastern Finland
  • Poul Hyttel & Kristine Freude, UCPH





































Group leader

Group Leader

Blanca Aldana
Associate Professor

Phone: +45 31541804

Group members

Name Title Phone E-mail
Nielsen, Heidi Marie Laboratory Technician +4535336333 E-mail