Christian Adam Olsen
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- Published
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism
Jørgensen, M., Olsen, Christian Adam, Mellor, I. R., Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2005, In: Journal of Medicinal Chemistry. 48, 1, p. 56-70 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities
Kitir, B., Maolanon, A. R., Ohm, R. G., Colaço, A. R., Fristrup, P., Madsen, A. S. & Olsen, Christian Adam, 26 Sep 2017, In: Biochemistry. 56, 38, p. 5134-5146 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells
Lai, J. I., Leman, L. J., Ku, S., Vickers, C. J., Olsen, Christian Adam, Montero, A., Ghadiri, M. R. & Gottesfeld, J. M., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3289-3293 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds
Laursen, J. S., Harris, Pernille, Fristrup, P. & Olsen, Christian Adam, 2015, In: Nature Communications. 6, p. 1-10 10 p., 7013.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-Peptoid Foldamers at Last
Laursen, J. S., Engel-Andreasen, J. & Olsen, Christian Adam, 20 Oct 2015, In: Accounts of Chemical Research. 48, 10, p. 2696-704 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cis-Trans Amide Bond Rotamers in beta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains
Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, Pernille & Olsen, Christian Adam, 20 Feb 2013, In: Journal of the American Chemical Society. 135, 7, p. 2835-2844Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction
Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optoepigenetics: An acetylation photoswitch
Madsen, A. S. & Olsen, Christian Adam, May 2016, In: Nature Chemical Biology. 12, 5, p. 306-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH
Madsen, A. S., Andersen, C., Daoud, M., Anderson, K. A., Laursen, J. S., Chakladar, S., Huynh, F. K., Colaco, A. R., Backos, D. S., Fristrup, P., Hirschey, M. D. & Olsen, Christian Adam, 25 Mar 2016, In: Journal of Biological Chemistry. 291, 13, p. 7128-7141 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme
Madsen, A. S. & Olsen, Christian Adam, 14 Jun 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5582-5590Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1-11
Madsen, A. S., Kristensen, H. M. E., Lanz, A. G. & Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 614-626 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action
Madsen, A. S. & Olsen, Christian Adam, 2016, In: MedChemComm. 7, p. 464-470 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes
Maolanon, A., Kristensen, H., Leman, L., Ghadiri, R. & Olsen, Christian Adam, 2017, In: ChemBioChem. 18, 1, p. 5-49 45 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Innovative Strategies for Selective Inhibition of Histone Deacetylases
Maolanon, A. R., Madsen, A. S. & Olsen, Christian Adam, 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 759-768 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles
Maolanon, A. R., Villadsen, J. S., Christensen, Niels Johan, Hoeck, C., Friis, T., Harris, P., Gotfredsen, C. H., Fristrup, P. & Olsen, Christian Adam, 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9644-9657 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal
Martín-Gago, P. & Olsen, Christian Adam, 21 Jan 2019, In: Angewandte Chemie - International Edition. 58, 4, p. 957-966 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
McDonnell, E., Crown, S. B., Fox, D. B., Kitir, B., Ilkayeva, O. R., Olsen, Christian Adam, Grimsrud, P. A. & Hirschey, M. D., 1 Nov 2016, In: Cell Reports. 17, 6, p. 1463-1472 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures
Montero, A., Beierle, J. M., Olsen, Christian Adam & Ghadiri, M. R., 4 Mar 2009, In: Journal of the American Chemical Society. 131, 8, p. 3033-3041Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays
Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: STAR Protocols. 2, 1, 14 p., 100313.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone Deacetylase 11 Is an ε- N -Myristoyllysine Hydrolase
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 May 2018, In: Cell Chemical Biology. 25, 7, p. 849-856Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chiral Posttranslational Modification to Lysine ε-Amino Groups
Moreno Yruela, Carlos, Baek, M., Monda, F. & Olsen, Christian Adam, 2022, In: Accounts of Chemical Research. 55, 10, p. 1456-1466Research output: Contribution to journal › Review › Research › peer-review
- Published
Elucidating the Enzymatic Activity of HDAC11
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases
Moreno Yruela, Carlos, Bæk, M., Vrsanova, A., Schulte, C., Maric, H. M. & Olsen, Christian Adam, 4 Jan 2021, In: Nature Communications. 12, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Synthesis of Trifluoromethyl Ketone Containing Amino Acid Building Blocks for the Preparation of Peptide-Based Histone Deacetylase (HDAC) Inhibitors
Moreno Yruela, Carlos & Olsen, Christian Adam, 2018, In: Synthesis. 50, 20, p. 4037-4046Research output: Contribution to journal › Journal article › Research › peer-review
ID: 101364066
Most downloads
-
2093
downloads
Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
391
downloads
Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
360
downloads
The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions
Research output: Contribution to journal › Journal article › Research › peer-review
Published