Jesper Langgaard Kristensen
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for alpha1-adrenoceptors
Kristensen, Jesper Langgaard, Pu¨schl, A., Jensen, M., Risgaard, R., Christoffersen, C. T., Bang-Andersen, B. & Balle, T., 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7021-7034Research output: Contribution to journal › Journal article › Research › peer-review
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Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
Bartuzi, D., Kędzierska, E., Targowska-Duda, K. M., Koszła, O., Wróbel, T. M., Jademyr, S., Karcz, T., Szczepańska, K., Stępnicki, P., Wronikowska-Denysiuk, O., Biała, G., Handzlik, J., Kristensen, Jesper Langgaard, Poso, A. & Kaczor, A. A., 2022, In: Scientific Reports. 12, 1, 14 p., 21192.Research output: Contribution to journal › Journal article › Research › peer-review
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Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice
Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, Mar 2015, In: Psychopharmacology. 232, 6, p. 1039-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides
Bornholdt, J., Fjære, K. W., Felding, J. & Kristensen, Jesper Langgaard, 2009, In: Tetrahedron. 65, 45, p. 9280-9284Research output: Contribution to journal › Journal article › Research › peer-review
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Histonhaler: et nyt mål inden for kræftbehandling
Kristensen, Jesper Langgaard, Lohse, B. & Clausen, Rasmus Prætorius, Dec 2010, In: Lægemiddelforskning. 2010, p. 7-9Research output: Contribution to journal › Journal article › Communication
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Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions
Johansen, A., Holm, S., Dall, B., Keller, S., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Hansen, H. D., 2019, In: EJNMMI Research. 9, p. 1-10 10 p., 71.Research output: Contribution to journal › Journal article › Research › peer-review
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IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657Research output: Patent
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Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide
Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging
Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, Vladimir, Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, Jesper Langgaard, Barz, M., Knudsen, Gitte Moos, Kjær, Andreas & Herth, Matthias Manfred, 1 Jan 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 986-990Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
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In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes
Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In: Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands
Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in rodents: Drug discrimination and thermoregulation
Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 1 Mar 2020, In: Drug and Alcohol Dependence. 208, 8 p., 107850.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Ind i hjernen med nye stoffer
Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In: Lægemiddelforskning. p. 34-36Research output: Contribution to journal › Journal article › Communication
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Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)
Leurs, U., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Lohse, B., 15 Sep 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitors of histone demethylases
Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist
Marcher, Emil, Nykodemová, J., Harpsøe, Kasper, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2023, In: ACS Medicinal Chemistry Letters. 14, 3, p. 319–325Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Brain Research. 401, 5 p., 113093.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists
Marcher, Emil, Halberstadt, A. L., Klein, A. K., Chatha, M., Jademyr, S., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. 11, p. 1238-1244Research output: Contribution to journal › Letter › Research › peer-review
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Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888
Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry
Steen, E. J. L., Jørgensen, Jesper Tranekjær, Denk, C., Battisti, Umberto Maria, Norregaard, K., Edem, P. E., Bratteby, K., Shalgunov, Vladimir, Wilkovitsch, M., Svatunek, D., Poulie, Christian Bernard Matthijs, Hvass, Lars, Simon, M., Wanek, T., Rossin, R., Robillard, M., Kristensen, Jesper Langgaard, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: ACS Pharmacology & Translational Science. 4, 2, p. 824-833 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization
Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 2020, In: Psychopharmacology. 237, p. 431–442Research output: Contribution to journal › Journal article › Research › peer-review
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Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension
Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Medicindepot dannes efter injektion i leddet
Larsen, Susan Weng, Thing, M. A., Østergaard, Jesper, Kristensen, Jesper Langgaard, Hansen, M. & Larsen, C. S., 2013, In: Lægemiddelforskning. 2013, p. 38-40Research output: Contribution to journal › Journal article › Research
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Metabolic fate of hallucinogenic NBOMes
Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands
Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87Research output: Contribution to journal › Journal article › Research › peer-review
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Nonracemic, chiral homoenolate reagents derived from (cycloalk-1-enyl)methyl carbamates and evaluation of their configurational stabilities
Özlügedik, M., Kristensen, Jesper Langgaard, Wibbeling, B., Fröhlich, R. & Hoppe, D., 1 Jan 2002, In: European Journal of Organic Chemistry. 3, p. 414-427 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships
Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421Research output: Contribution to journal › Journal article › Research › peer-review
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Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Petersen, I. N., Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 18 Jan 2017, In: European Journal of Organic Chemistry. 2017, 3, p. 453-458 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ny bioisoster kan skabe nye lægemidler
Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2004, In: Lægemiddelforskning. 2004, p. 16-17Research output: Contribution to journal › Journal article › Communication
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Nye NMDA-receptor-ligander til udforskning af hjernen
Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In: Dansk Kemi. 91, 6/7, p. 21-23Research output: Contribution to journal › Journal article › Communication
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Ortho lithiation-in situ borylation of substituted morpholine benzamides
Cederbalk, A., Lysén, M., Kehler, J. & Kristensen, Jesper Langgaard, 23 Mar 2017, In: Tetrahedron. 73, 12, p. 1576–1582 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Overcoming Energy Transfer for the Metallophotoredox Catalyzed Decarboxylative Alkenylation between Alkylcarboxylic Acids and Enol Triflates
Pedersen, S. K., Clementson, S., Kristensen, Jesper Langgaard, Jessing, M. & El-Chami, K., 2023, In: Chemistry: A European Journal. 29, 35, e202300265.Research output: Contribution to journal › Journal article › Research › peer-review
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PRODRUGS OF NAPROXEN AND DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530Research output: Patent
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PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591Research output: Patent
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Palladium-Catalyzed Arylation and Acylation of 1-Benzyloxy-1,2,3-triazole Through a Directed Ortho Lithiation-Transmetalation Strategy.
Felding, J., Uhlmann, P., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1998, In: Synthesis. 8, p. 1181-1184 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
Trost, B. M., Schroeder, G. M. & Kristensen, Jesper Langgaard, 16 Sep 2002, In: Angewandte Chemie International Edition. 41, 18, p. 3492-3495 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes
Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro
Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In: P L o S One. 8, 7, p. e67653Research output: Contribution to journal › Journal article › Research › peer-review
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Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36
Ettrup, A., Holm, S., Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In: Molecular Imaging and Biology. 15, 4, p. 376-83Research output: Contribution to journal › Journal article › Research › peer-review
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Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling
Kristensen, Jesper Langgaard, Begtrup, M. & Vedsø, P., 1 Nov 1998, In: Synthesis. 11, p. 1604-1608 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pretargeted PET imaging using a dual click F-18-labeling strategy: [Meeting Abstract]
Steen, J., Denk, C., Jørgensen, Jesper Tranekjær, Norregard, K., Rossin, R., Wilkovitsch, M., Svatunek, D., Edem, P., Kuntner, C., Wanek, T., Robillard, M., Kristensen, Jesper Langgaard, Kjær, Andreas, Mikula, H. & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S22-S23 O-08.Research output: Contribution to journal › Conference abstract in journal › Research
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Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor
L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In: Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936
Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors
Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646Research output: Contribution to journal › Journal article › Research › peer-review
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Ring opening of pymisyl-protected aziridines with organocuprates
Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480Research output: Contribution to journal › Journal article › Research › peer-review
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Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36
Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Snegleprotein øger forståelsen af vigtige receptorer i hjernen
Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.Research output: Contribution to journal › Journal article › Communication
ID: 1305029
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Convenient access to F-18-labeled amines through the Staudinger reduction
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331
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
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