Jens Velde Andersen
Guest Researcher
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2023
- Published
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes
Andersen, Jens Velde & Schousboe, Arne, 2023, In: Journal of Neurochemistry. 166, 2, p. 109-137Research output: Contribution to journal › Review › Research › peer-review
- Published
β-Hydroxybutyrate and Medium-Chain Fatty Acids are Metabolized by Different Cell Types in Mouse Cerebral Cortex Slices
Andersen, Jens Velde, Westi, Emil Winther, Neal, E. S., Aldana, Blanca & Borges, K., 2023, In: Neurochemical Research. 48, p. 54–61Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice
McNair, Laura M., Andersen, Jens Velde & Waagepetersen, Helle S., 2023, In: Neurochemistry International. 171, 10 p., 105626.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions
Westi, Emil Winther, Andersen, Jens Velde & Aldana, Blanca, 2023, In: Neurobiology of Disease. 182, 12 p., 106145.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle
Andersen, Jens Velde, Schousboe, Arne & Verkhratsky, A., 2022, In: Progress in Neurobiology. 217, 24 p., 102331.Research output: Contribution to journal › Review › Research › peer-review
- Published
Progressive Mitochondrial Dysfunction of Striatal Synapses in R6/2 Mouse Model of Huntington's Disease
Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Madsen, M., Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, 2022, In: Journal of Huntington's disease. 11, 2, p. 121-140Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone
Sorensen, M., Walls, Anne Byriel, Dam, G., Bak, Lasse Kristoffer, Andersen, Jens Velde, Ott, P., Vilstrup, H. & Schousboe, Arne, 2022, In: Analytical Biochemistry. 654, 4 p., 114766.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease
Tams, A. L. M., Sanz-Morello, B., Westi, Emil Winther, Mouhammad, Zaynab Ahmad, Andersen, Jens Velde, Freude, Kristine, Vohra, Rupali, Hannibal, Jens, Aldana, Blanca & Kolko, Miriam, 2022, In: Cellular and Molecular Neurobiology. 42, 1, p. 291–303Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
Andersen, Jens Velde, Westi, Emil Winther, Jakobsen, Emil, Urruticoechea, N., Borges, K. & Aldana, Blanca, 2021, In: Molecular Brain. 14, 1, 13 p., 132.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, Jens Velde, Christensen, S. K., Westi, Emil Winther, Diaz-delcastillo, M., Tanila, H., Schousboe, Arne, Aldana, Blanca & Waagepetersen, Helle S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.Research output: Contribution to journal › Review › Research › peer-review
- Published
Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of translation by site-specific ribosomal RNA methylation
Jansson, Martin David, Häfner, Sophia Julia, Altinel, Kübra, Tehler, D. E., Krogh, Nicolai, Jakobsen, Emil, Andersen, Jens Velde, Andersen, Kasper Langebjerg, Schoof, E., Ménard, Patrice, Nielsen, Henrik & Lund, Anders H., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 889-899Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
Rimmele, T. S., Li, S., Andersen, Jens Velde, Westi, Emil Winther, Rotenberg, A., Wang, J., Aldana, Blanca, Selkoe, D. J., Aoki, C. J., Dulla, C. G. & Rosenberg, P. A., 2021, In: Frontiers in Cellular Neuroscience. 15, 788262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Wagner, A., Andersen, Jens Velde, Vinten, K. T., Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine & Aldana, Blanca, 2021, In: Neurochemical Research. 46, p. 2676–2686Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Andersen, Jens Velde, Vinten, K. T., Pinborg, Lars Hageman, Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2021, In: Frontiers in Aging Neuroscience. 13, 736580.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex
Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
McNair, Laura M., Andersen, Jens Velde, Nissen, J. D., Sun, Y., Fischer, K. D., Hodgson, N. W., Du, M., Aoki, C. J., Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2020, In: Neurochemical Research. 45, p. 1420–1437 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics
Voss, C. M., Andersen, Jens Velde, Jakobsen, Emil, Siamka, O., Karaca, M., Maechler, P. & Waagepetersen, Helle S., 2020, In: Glia. 68, 9, p. 1824-1839 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria
Andersen, Jens Velde, Jakobsen, Emil, Waagepetersen, Helle S. & Aldana, Blanca, 2019, In: Journal of Neuroscience Research. 97, p. 961–974Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease
Andersen, Jens Velde, Skotte, Niels Henning, Aldana, Blanca, Nørremølle, Anne & Waagepetersen, Helle S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice
Arildsen, L., Andersen, Jens Velde, Waagepetersen, Helle S., Nissen, J. B. D. & Sheykhzade, Majid, 2019, In: Diabetes and Vascular Disease Research. 16, 6, p. 539 548 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The energetic brain - A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Freitas, A. E., Freitas, G. B., Gonçalves, R. A., Gupta, D., Ha, S. R., Hemming, I. A., Jaggar, M., Jakobsen, E., Kumari, P., Lakkappa, N., L Marsh, A. P. & 14 others, , Oct 2019, In: Journal of Neurochemistry. 151, 2, p. 139-165Research output: Contribution to journal › Review › Research › peer-review
- Published
Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function
McNair, Laura M., Andersen, Jens Velde, Aldana, Blanca, Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N., Webster, S. C., Kapur, K., Rimmele, T. S., Barone, I., Hawks-Mayer, H., Lipton, J. O., Hodgson, N. W., Aoki, C. J., Rosenberg, P. A. & Waagepetersen, Helle S., 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 25, p. 4847-4863Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex
Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, May 2019, In: Neuroscience. 406, p. 432-443 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate homeostasis revisited - neuronal transport and metabolism
Waagepetersen, Helle S., McNair, Laura M., Christensen, S. K., Andersen, Jens Velde & Aldana, Blanca, 2019, p. 19-19.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2018
- Published
Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation
Hohnholt, M. C., Andersen, V. H., Andersen, Jens Velde, Christensen, S. K., Karaca, M., Maechler, P. & Waagepetersen, Helle S., Oct 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 10, p. 1754–1768Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana, Blanca, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In: Cell Reports. 23, 7, p. 2211-2224 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease
Andersen, Jens Velde, Christensen, S. K., Aldana, Blanca, Nissen, J. D., Tanila, H. & Waagepetersen, Helle S., Jun 2017, In: Neurochemical Research. 42, 6, p. 1589–1598Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved cerebral energetics and ketone body metabolism in db/db mice
Andersen, Jens Velde, Christensen, S. K., Nissen, J. D. & Waagepetersen, Helle S., Mar 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 1137–1147 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus
Andersen, Jens Velde, Nissen, J. D., Christensen, S. K., Markussen, K. H. & Waagepetersen, Helle S., 2017, In: Neural Plasticity. 2017, p. 2107084 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis
Andersen, Jens Velde, McNair, Laura M., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-(13)C]Glucose and [1,2-(13)C]Acetate as Substrates
McNair, Laura M., Kornfelt, R., Walls, Anne Byriel, Andersen, Jens Velde, Aldana, B. I., Nissen, J. D., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 3, p. 810-826 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 124861414
Most downloads
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370
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Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
254
downloads
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
171
downloads
Glutamate homeostasis revisited - neuronal transport and metabolism
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published