Alexander Sebastian Hauser
Associate Professor
Pharmaceutical Informatics
Universitetsparken 2
2100 København Ø
- 2024
- Accepted/In press
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
Reiner-Link, David, Madsen, Jakob Sture, Gloriam, David E., Bräuner, Hans & Hauser, Alexander Sebastian, 2024, (Accepted/In press) In: British Journal of Pharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
G protein-coupled receptor (GPCR) gene variants and human genetic disease
Thompson, M. D., Percy, M. E., Cole, D. E. C., Bichet, D. G., Hauser, Alexander Sebastian & Gorvin, C. M., 2024, (Accepted/In press) In: Critical Reviews in Clinical Laboratory Sciences.Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Published
A community Biased Signaling Atlas
Caroli, J., Mamyrbekov, A., Harpsøe, Kasper, Gardizi, S., Dörries, L., Ghosh, E., Hauser, Alexander Sebastian, Kooistra, Albert J. & Gloriam, David E., 2023, In: Nature Chemical Biology. 19, p. 531–535Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes
Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
Wright, S. C., Motso, A., Koutsilieri, S., Beusch, C. M., Sabatier, Pierre Camille, Berghella, A., Blondel-Tepaz, É., Mangenot, K., Pittarokoilis, I., Sismanoglou, D. C., Le Gouill, C., Olsen, Jesper Velgaard, Zubarev, R. A., Lambert, N. A., Hauser, Alexander Sebastian, Bouvier, M. & Lauschke, V. M., 2023, In: Nature Communications. 14, 1, 13 p., 6243.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, Alexander Sebastian, Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, David E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity
Gasparri, F., Sarkar, Debayan, Bielickaite, S., Poulsen, Mette Homann, Hauser, Alexander Sebastian & Pless, Stephan, 2022, In: British Journal of Pharmacology. 179, 14, p. 3859-3874Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common coupling map advances GPCR-G protein selectivity
Hauser, Alexander Sebastian, Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, David E., 2022, In: eLife. 11, 22 p., e74107.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection
Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The G protein database, GproteinDb
Pándy-Szekeres, Gáspár, Esguerra, M., Hauser, Alexander Sebastian, Caroli, J., Munk, C., Pilger, S., Keseru, G. M., Kooistra, Albert J. & Gloriam, David E., 2022, In: Nucleic Acids Research. 50, D1, p. D518-D525Research output: Contribution to journal › Journal article › Research › peer-review
ID: 143688078
Most downloads
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563
downloads
Pharmacogenomics of GPCR Drug Targets
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
434
downloads
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
320
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GPCRdb: an information system for G protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
Published