Lasse Kristoffer Bak

Lasse Kristoffer Bak

Guest Researcher, Professor

ORCID: 0000-0003-0784-7864

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  1. Published

    PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

    Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Azevedo, C., Roybon, L., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 297.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

    Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

    Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

    Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

    Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)

    Walls, Anne Byriel, Bak, Lasse Kristoffer, Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

    Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone

    Sorensen, M., Walls, Anne Byriel, Dam, G., Bak, Lasse Kristoffer, Andersen, Jens Velde, Ott, P., Vilstrup, H. & Schousboe, Arne, 2022, In: Analytical Biochemistry. 654, 4 p., 114766.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

    Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

    Müller, M. S., Pedersen, Sofie E., Walls, Anne Byriel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Jan 2015, In: Glia. 63, 1, p. 154-62 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Is neuronal utilization of glucose and lactate linked to Ca2+-dependent modulation of malate-aspartate shuttle activity?

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Walls, Anne Byriel & Schousboe, Arne, 2008.

    Research output: Contribution to conference › Poster › Research

  15. Published

    Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

    Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes

    Jakobsen, Emil, Madsen, S. F., Hedehus, J., Rubio-Villena, C., Jorgensen, N. H. & Bak, Lasse Kristoffer, Aug 2017, p. 147-147.

    Research output: Contribution to conference › Poster › Research

  17. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

    Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Keiding, S., Schousboe, Arne & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Impact of the malate-aspartate shuttle in glutamate neurotransmission

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9

    Research output: Contribution to journal › Conference abstract in journal › Research

  20. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

    Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Glutamine and ammonia in hepatic encephalopathy

    Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Glutamate metabolism in the brain focusing on astrocytes

    Schousboe, Arne, Scafidi, S., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 26 Apr 2013, In: Neurochemical Research. 39, 3, p. 487-499

    Research output: Contribution to journal › Journal article › Research › peer-review

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