Henrik Franzyk
Associate Professor
- Published
Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability
Xu, You, Turan, E. T., Shi, Z., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes
Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.Research output: Contribution to conference › Poster › Research
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Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768Research output: Contribution to journal › Journal article › Research
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Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation
Wu, B. C., Skovbakke, S. L., Masoudi, H., Hancock, R. E. W. & Franzyk, Henrik, 2020, In: Frontiers in Immunology. 11, 11 p., 2102.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics
Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
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Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs, or antibiotics against human pathogenic bacteria
Citterio, L., Franzyk, Henrik, Palarasah, Y., Andersen, T. E., Mateiu, R. V. & Gram, L., Feb 2016, In: Research in Microbiology. 167, 2, p. 72-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein
Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, Thomas, Franzyk, Henrik, Pedersen, Anders Elm, Papadakis, C. M., Christensen, D., Winter, G., Foged, Camilla & Hubert, M., 10 Sep 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation
Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation
Dormenval, C., Lokras, Abhijeet, Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 10, 142.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures
McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.Research output: Contribution to journal › Journal article › Research › peer-review
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Håb om at ramme latente bakterier i deres skjul
Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14Research output: Contribution to journal › Journal article › Research
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Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin
Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hurtige genveje til nye lægemidler
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2003, In: Lægemiddelforskning. 2003, p. 8-9 2 p.Research output: Contribution to journal › Journal article › Communication
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Human plasma potentiates antibacterial effect of peptidomimetics against Gram-negative and Gram-positive pathogenic bacteria
Citterio, L., A, K., K, H., Franzyk, Henrik & Gram, L., 2014.Research output: Contribution to conference › Poster › Research
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Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.Research output: Contribution to journal › Journal article › Research › peer-review
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High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Halohydrins and Polyols Derived from Antirrhinoside: Structural Revision of Muralioside and Epimuralioside
Franzyk, Henrik, Jensen, S. R., Thale, Z. & Olsen, C. E., 1999, In: Journal of Natural Products. 62, p. 275-278 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Guide til Rapportskrivning i Kurset Biopharmaceuticals: Bioorganisk Kemi 2018
Franzyk, Henrik, 2018, 17 p.Research output: Book/Report › Compendium/lecture notes › Education
Glycopeptide Mimics of Mammalian Man9GlcNAc2. Ligand Binding to Mannan Binding Proteins (MBPs)
Franzyk, Henrik, Meldal, M., Paulsen, H., Thiel, S., Jensenius, J. C. & Bock, K., 1996, In: Bioorganic and Medicinal Chemistry. 4, p. 1881-1899 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins
Olsen, Christian Adam, Witt, M., Hansen, S. H., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Tetrahedron. 61, p. 6046-6055 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fontanesioside and 5-Hydroxysecologanol from Fontanesia phillyreoides.
Damtoft, S., Franzyk, Henrik & Jensen, S. R., 1994, In: Phytochemistry. 35, p. 705-711 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis
Shaikh, Ashif Yasin, Hansen, A. M. & Franzyk, Henrik, 2020, Peptide Nucleic Acids: Methods and Protocols. P. E. N. (ed.). Humana Press, p. 1-16 16 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2105).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction
Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency
Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fastfase-syntese af Peptider - en visuel guide
Franzyk, Henrik, 2018, 18 p.Research output: Book/Report › Compendium/lecture notes › Education
- Published
Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage
Hansen, A. M., Shaikh, Ashif Yasin & Franzyk, Henrik, 2020, Peptide Nucleic Acids: Methods and Protocols. P. E. N. (ed.). Humana Press, p. 97-118 22 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2105).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Expedite Protocol for Construction of Chiral Regioselectively N-Protected Monosubstituted Piperazine, 1,4-Diazepane, and 1,4-Diazocane Building Blocks
Crestey, F., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 11 Jun 2009, In: Journal of Organic Chemistry. 74, 15, p. 5652-5655Research output: Contribution to journal › Journal article › Research › peer-review
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Expedient protocol for solid-phase synthesis of secondary and tertiary amines
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Organic Letters. 6, 12, p. 1935-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Excelsioside, a Secoiridoid Glucoside from Fraxinus excelsior L.
Damtoft, S., Franzyk, H. & Jensen, S. R., D. S. ,. F. H. &. J. S. R., 1992, In: Phytochemistry. 31, p. 4197-4201Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation
Wester, A., Björkling, Fredrik & Franzyk, Henrik, 2021, In: The Journal of Organic Chemistry. 86, 21, p. 14371–14380Research output: Contribution to journal › Journal article › Research › peer-review
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Escherichia coli with resistance to α-peptide/β-peptoid peptidomimetics: Mutation of a gene related to structural changes of cell wall peptidoglycan
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2012.Research output: Contribution to conference › Poster › Research
- Published
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Ziegler, H. L., Franzyk, Henrik, Sairafianpour, M., Tabatabai, M., Tehrani, M. D., Bagherzadeh, K., Hägerstrand, H., Stærk, Dan & Jaroszewski, J. W., 2004, In: Bioorganic & Medicinal Chemistry. 12, p. 119-127Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: "Naravelia zeylanica: Occurrence of primary benzamides in flowering plants" (Natural Product Research vol. 19 (3) (291-294))
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H., Franzyk, Henrik & Somanadhan, B., 1 Jun 2005, In: Natural Product Research. 19, 4, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria
Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles
Aljabbari, Anas Samir Mohammad, Lokras, Abhijeet, Kirkensgaard, Jacob Judas Kain, Rades, Thomas, Franzyk, Henrik, Thakur, A., Zhang, Y. & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 907-922Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors
Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.Research output: Contribution to conference › Poster › Research
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Efficient loading of primary alcohols onto a solid phase using a trityl bromide linker
Crestey, F., Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2008, In: Tetrahedron Letters. 49, 41, p. 5890-5893Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.
Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.Research output: Contribution to conference › Poster › Research
- Published
Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
Hellewell, L., Gilani, N. M., Stanton, C. J., Pelligand, L., Franzyk, Henrik, Guardabassi, Luca & Good, L., 2022, In: Future Medicinal Chemistry. 14, 24, p. 1899–1921Research output: Contribution to journal › Review › Research › peer-review
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Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies
Xu, Y., Cañadas, O., Alonso, A., Franzyk, Henrik, Thakur, A., Pérez-gil, J. & Foged, Camilla, 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
Most downloads
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2004
downloads
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1600
downloads
Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
Published -
1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published