Annette Eva Langkilde

Annette Eva Langkilde

Associate Professor

ORCID: 0000-0003-2467-4205

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  1. Published

    Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

    Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

    Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Accepted/In press

    Sex-dependent effects of monomeric α-syn on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin

    Bohid, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Langkilde, Annette Eva, Brito dos Santos, Altair & Kohlmeier, Kristi Anne, 2024, (Accepted/In press) In: Molecular and Cellular Neurosciences.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease

    Brito dos Santos, Altair, Skaanning, L. K., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Kristensen, M. P., Klein, A. B., Thaneshwaran, S. S., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1773-1790

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

    Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

    Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

    Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    Brito dos Santos, Altair, Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2022, In: Cellular and Molecular Life Sciences. 79, 8, 450.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The structural basis of fungal glucuronoyl esterase activity on natural substrates

    Ernst, H. A., Mosbech, C., Langkilde, Annette Eva, Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, Sine, 2020, In: Nature Communications. 11, 1026, p. 1-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

    Juul-madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, Annette Eva, Vestergaard, Bente, Howard, K. A., Dehesa-etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-ramos, M. & Vorup-jensen, T., 22 Jan 2020, In: The Journal of Immunology. 204, 5, p. 1345-1361

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Monomeric α-synuclein activates the plasma membrane calcium pump

    Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

    Langkilde, Annette Eva & Vestergaard, Bente, 2009, In: FEBS Letters. 583, 16, p. 2600-2609

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

    Langkilde, Annette Eva, Herranz-Trillo, F., Bernadó, P. & Vestergaard, Bente, 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  14. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

    Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Protein fibrillation from another small angle—SAXS data analysis of developing systems

    Langkilde, Annette Eva & Vestergaard, Bente, 2023, Methods in Enzymology. Elsevier, Vol. 678. p. 377-409

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  16. Published

    Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

    Langkilde, Annette Eva & Vestergaard, Bente, 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  17. Published

    Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

    Langkilde, Annette Eva, Oddershede, J. & Larsen, Sine, 2002, In: Acta Crystallographica B. 58, p. 1044-1050

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

    Langkilde, Annette Eva, Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, Bente, Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

    Langkilde, Annette Eva, Madsen, D. & Larsen, Sine, 2004, In: Acta Crystallographica. B60, p. 502-511

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information

    Langkilde, Annette Eva, 2008, Kemisk Institut, Københavns Universitet.

    Research output: Book/Report › Ph.D. thesis › Research

  21. Published

    Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

    Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Wildtype and A30P mutant alpha-synuclein form different fibril structures

    Nielsen, S. B., Macchi, F., Raccosta , S., Langkilde, Annette Eva, Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, Bente & Otzen, D., 2013, In: PLOS ONE. 8, 7, e67713.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

    Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, Annette Eva & Vestergaard, Bente, Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

    Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

    Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 2021, In: IUCrJ. 8, 3, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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