Annette Eva Langkilde
Associate Professor
Structural Biology
Universitetsparken 2
2100 København Ø
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Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.Research output: Contribution to journal › Journal article › Research › peer-review
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Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates
Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sex-dependent effects of monomeric α-syn on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin
Bohid, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Langkilde, Annette Eva, Brito dos Santos, Altair & Kohlmeier, Kristi Anne, 2024, In: Molecular and Cellular Neurosciences. 129, 14 p., 103934.Research output: Contribution to journal › Journal article › Research › peer-review
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α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease
Brito dos Santos, Altair, Skaanning, L. K., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Kristensen, M. P., Klein, A. B., Thaneshwaran, S. S., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1773-1790Research output: Contribution to journal › Journal article › Research › peer-review
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Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior
Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies
Brito dos Santos, Altair, Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2022, In: Cellular and Molecular Life Sciences. 79, 8, 450.Research output: Contribution to journal › Journal article › Research › peer-review
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The structural basis of fungal glucuronoyl esterase activity on natural substrates
Ernst, H. A., Mosbech, C., Langkilde, Annette Eva, Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, Sine, 2020, In: Nature Communications. 11, 1026, p. 1-12Research output: Contribution to journal › Journal article › Research › peer-review
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Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4
Juul-madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, Annette Eva, Vestergaard, Bente, Howard, K. A., Dehesa-etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-ramos, M. & Vorup-jensen, T., 22 Jan 2020, In: The Journal of Immunology. 204, 5, p. 1345-1361Research output: Contribution to journal › Journal article › Research › peer-review
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Monomeric α-synuclein activates the plasma membrane calcium pump
Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.Research output: Contribution to journal › Journal article › Research › peer-review
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Methods for structural characterization of prefibrillar intermediates and amyloid fibrils
Langkilde, Annette Eva & Vestergaard, Bente, 2009, In: FEBS Letters. 583, 16, p. 2600-2609Research output: Contribution to journal › Journal article › Research › peer-review
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Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering
Langkilde, Annette Eva, Herranz-Trillo, F., Bernadó, P. & Vestergaard, Bente, 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863Research output: Contribution to journal › Journal article › Research › peer-review
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Protein fibrillation from another small angle—SAXS data analysis of developing systems
Langkilde, Annette Eva & Vestergaard, Bente, 2023, Methods in Enzymology. Elsevier, Vol. 678. p. 377-409Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering
Langkilde, Annette Eva & Vestergaard, Bente, 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy
Langkilde, Annette Eva, Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, Bente, Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities
Langkilde, Annette Eva, Oddershede, J. & Larsen, Sine, 2002, In: Acta Crystallographica B. 58, p. 1044-1050Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion
Langkilde, Annette Eva, Madsen, D. & Larsen, Sine, 2004, In: Acta Crystallographica. B60, p. 502-511Research output: Contribution to journal › Journal article › Research › peer-review
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High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information
Langkilde, Annette Eva, 2008, Kemisk Institut, Københavns Universitet.Research output: Book/Report › Ph.D. thesis › Research
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The first lesson in the classroom - getting students engaged in active learning process
Langkilde, Annette Eva, 2011, Improving University Science Teaching and Learning: Pedagogical Projects 2010. Ulriksen, L., Rump, C. & Hansen, H. W. (eds.). Department of Science Education, University of Copenhagen, Vol. 3. p. 3-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.Research output: Contribution to journal › Journal article › Research › peer-review
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Wildtype and A30P mutant alpha-synuclein form different fibril structures
Nielsen, S. B., Macchi, F., Raccosta , S., Langkilde, Annette Eva, Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, Bente & Otzen, D., 2013, In: PLOS ONE. 8, 7, e67713.Research output: Contribution to journal › Journal article › Research › peer-review
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Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization
Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, Annette Eva & Vestergaard, Bente, Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme
Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme
Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 2021, In: IUCrJ. 8, 3, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets
Sagar, A., Herranz-Trillo, F., Langkilde, Annette Eva, Vestergaard, Bente & Bernadó, P., 2021, In: Structure. 29, 9, p. 1074-1090Research output: Contribution to journal › Journal article › Research › peer-review
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Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies
Brito dos Santos, Altair, Skaanning, L. K., Thaneskwaran, S., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 9 May 2022, Research Square-Preprint, 46 p.Research output: Working paper › Preprint › Research
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Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Brito dos Santos, Altair, Thaneshwaran, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Wang, Y., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2023, In: Cell & Bioscience. 13, 1, 16 p., 172.Research output: Contribution to journal › Journal article › Research › peer-review
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Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Brito dos Santos, Altair, Thaneshwaran, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Wang, Yang, Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2023, Research Square-Preprint, 29 p.Research output: Working paper › Preprint › Research
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Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S., Hunter, M. S. & 7 others, , 9 May 2018, In: Nature Communications. 9, 1, 10 p., 1836.Research output: Contribution to journal › Journal article › Research › peer-review
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The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin
Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, Bente, Bugge, K., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: Biomolecules. 10, 8, 23 p., 1192.Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils
Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching
Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, , 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery
Solbak, Sara Marie Øie, Zang, J., Narayanan, Dilip, Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, Annette Eva, Gotfredsen, C. H., Sattler, M. & Bach, Anders, 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177Research output: Contribution to journal › Journal article › Research › peer-review
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Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases
Solomon, M., Foderà, Vito, Langkilde, Annette Eva, Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
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Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene
Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, Theis Ivan, Langkilde, Annette Eva & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108Research output: Contribution to journal › Journal article › Research › peer-review
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In-depth analysis of subclass-specific conformational preferences of IgG antibodies
Tian, X., Vestergaard, Bente, Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, Annette Eva, 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4
Tian, X., Langkilde, Annette Eva, Thorolfsson, M., Rasmussen, H. B. & Vestergaard, Bente, Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein fibrillation from another small angle: Sample preparation and SAXS data collection
Vestergaard, Bente & Langkilde, Annette Eva, 2022, Methods in Enzymology. Academic Press, Vol. 677. p. 291-321 (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors
Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005Research output: Contribution to journal › Journal article › Research › peer-review
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Formation of covalent di-tyrosine dimers in recombinant α-synuclein
van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers
van Maarschalkerweerd, A., Vetri, V., Langkilde, Annette Eva, Foderà, Vito & Vestergaard, Bente, 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11736
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Wildtype and A30P mutant alpha-synuclein form different fibril structures
Research output: Contribution to journal › Journal article › Research › peer-review
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The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy
Research output: Contribution to journal › Journal article › Research › peer-review
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136
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Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
Research output: Contribution to journal › Journal article › Research › peer-review
Published