Annette Eva Langkilde

Annette Eva Langkilde

Associate Professor

ORCID: 0000-0003-2467-4205

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  1. Published

    Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

    Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

    Solbak, Sara Marie Øie, Zang, J., Narayanan, Dilip, Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, Annette Eva, Gotfredsen, C. H., Sattler, M. & Bach, Anders, 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

    Langkilde, Annette Eva, Oddershede, J. & Larsen, Sine, 2002, In: Acta Crystallographica B. 58, p. 1044-1050

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

    Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

    Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

    Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S., Hunter, M. S. & 7 others, Koglin, J., Liang, M., Ginn, H. M., Millane, R. P., Frank, M., Barty, A. & Chapman, H. N., 9 May 2018, In: Nature Communications. 9, 1, 10 p., 1836.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Formation of covalent di-tyrosine dimers in recombinant α-synuclein

    van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information

    Langkilde, Annette Eva, 2008, Kemisk Institut, Københavns Universitet.

    Research output: Book/Report › Ph.D. thesis › Research

  9. Published

    Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils

    Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    In-depth analysis of subclass-specific conformational preferences of IgG antibodies

    Tian, X., Vestergaard, Bente, Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, Annette Eva, 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

    Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

    Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, Saar, Daniel, Blæsild, H., Stahlhut, M., Andersen, K. V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L. & Kragelund, Birthe Brandt, 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

    Langkilde, Annette Eva & Vestergaard, Bente, 2009, In: FEBS Letters. 583, 16, p. 2600-2609

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

    Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, Annette Eva & Vestergaard, Bente, Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Monomeric α-synuclein activates the plasma membrane calcium pump

    Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

    Langkilde, Annette Eva, Herranz-Trillo, F., Bernadó, P. & Vestergaard, Bente, 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  17. Published

    Protein fibrillation from another small angle: Sample preparation and SAXS data collection

    Vestergaard, Bente & Langkilde, Annette Eva, 2022, Methods in Enzymology. Academic Press, Vol. 677. p. 291-321 (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  18. Published

    Protein fibrillation from another small angle—SAXS data analysis of developing systems

    Langkilde, Annette Eva & Vestergaard, Bente, 2023, Methods in Enzymology. Elsevier, Vol. 678. p. 377-409

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  19. Published

    Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

    van Maarschalkerweerd, A., Vetri, V., Langkilde, Annette Eva, Foderà, Vito & Vestergaard, Bente, 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases

    Solomon, M., Foderà, Vito, Langkilde, Annette Eva, Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

    Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Accepted/In press

    Sex-dependent effects of monomeric α-syn on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin

    Bohid, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Langkilde, Annette Eva, Brito dos Santos, Altair & Kohlmeier, Kristi Anne, 2024, (Accepted/In press) In: Molecular and Cellular Neurosciences.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

    Brito dos Santos, Altair, Thaneshwaran, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Wang, Yang, Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2023, Research Square-Preprint, 29 p.

    Research output: Working paper › Preprint › Research

  24. Published

    Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

    Brito dos Santos, Altair, Thaneshwaran, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Wang, Y., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2023, In: Cell & Bioscience. 13, 1, 16 p., 172.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

    Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

    Research output: Contribution to journal › Journal article › Research › peer-review

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