Blanca Aldana
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2024
- Published
Role of S1P and RhoA/Rho-kinase pathways in age-related myogenic tone deficiency in mouse small mesenteric and cerebral arteries
Skovsted, G. F., Aupetit, A., Björling , K., Haanes, K. A., Syberg, S., Jørgensen, N. R., Aldana, Blanca, Freude, Kristine, Pearson, J. T. & Jensen, Lars Jørn, 2 Jul 2024.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- E-pub ahead of print
Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease
Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, Aisha, Gegelashvili, G., Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3
Haukedal, H., Syshøj Lorenzen, S., Westi, Emil Winther, Corsi, G., Gadekar, V. P., McQuade, A., Davtyan, H., Doncheva, Nadezhda Tsankova, Schmid, B., Chandrasekaran, Abinaya, Seemann, Ernst Stefan, Cirera, Susanna, Blurton-Jones, M., Meyer, M., Gorodkin, Jan, Aldana, Blanca & Freude, Kristine, 2023, In: Brain, Behavior, and Immunity. 113, p. 353-373Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of Alzheimer's Disease
Abghari, M., Vu, J. T. C. M., Eckberg, N., Aldana, Blanca & Kohlmeier, Kristi Anne, 2023, In: Biomolecules. 13, 10, 25 p., 1461.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma
Lewinska, M., Zhuravleva, E., Satriano, L., Martinez, M. B., Bhatt, D. K., Oliveira, D. V. N. P., Antoku, Y., Keggenhoff, F. L., Castven, D., Marquardt, J. U., Matter, M. S., Erler, J. T., Oliveira, R. C., Aldana, B. I., Al-Abdulla, R., Perugorria, M. J., Calvisi, D. F., Perez, L. A., Rodrigues, P. M., Labiano, I. & 2 others, , 2023, In: Gastroenterology. 166, 5, p. 886-901Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Golgi fragmentation: One of the earliest organelle phenotypes in Alzheimer's disease neurons
Haukedal, H., Corsi, G. I., Gadekar, V. P., Doncheva, N. T., Kedia, S., de Haan, N., Chandrasekaran, A., Jensen, P., Schiønning, P., Vallin, S., Marlet, F. R., Poon, A., Pires, C., Agha, F. K., Wandall, H. H., Cirera, S., Simonsen, A. H., Nielsen, T. T., Nielsen, J. E., Hyttel, P. & 7 others, , 2023, In: Frontiers in Neuroscience. 17, 17 p., 1120086.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells
Duwe, Lea, Munoz-Garrido, P., Lewinska, Monika, Lafuente Barquero, Juan Francisco, Satriano, L., Høgdall, Dan Taksony Solyom, Taranta, A., Nielsen, B. S., Ghazal, A., Matter, M. S., Banales, J. M., Aldana, Blanca, Gao, Y., Marquardt, J. U., Roberts, L. R., Oliveira, R. C., Koshiol, J., O'Rourke, Colm & Andersen, Jesper Bøje, 2023, In: Journal of Hepatology. 78, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potential Retinal Biomarkers in Alzheimer's Disease
Garcia Bermudez, Mariana Yolotzin, Vohra, Rupali, Freude, Kristine, van Wijngaarden, P., Martin, K. K., Thomsen, M. S., Aldana, Blanca & Kolko, Miriam, 2023, In: International Journal of Molecular Sciences (Online). 24, 21, 26 p., 15834.Research output: Contribution to journal › Review › Research › peer-review
- Published
Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer's disease
Zhukov, Oleg, He, Chen, Soylu-Kucharz, R., Cai, Changsi, Lauritzen, Andreas, Aldana, Blanca, Björkqvist, M., Lauritzen, Martin & Kucharz, Krzysztof, 2023, In: Frontiers in Aging Neuroscience. 15, 18 p., 1089005.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions
Westi, Emil Winther, Andersen, Jens Velde & Aldana, Blanca, 2023, In: Neurobiology of Disease. 182, 12 p., 106145.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-Hydroxybutyrate and Medium-Chain Fatty Acids are Metabolized by Different Cell Types in Mouse Cerebral Cortex Slices
Andersen, Jens Velde, Westi, Emil Winther, Neal, E. S., Aldana, Blanca & Borges, K., 2023, In: Neurochemical Research. 48, p. 54–61Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2022
- Published
Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease
Tams, A. L. M., Sanz-Morello, B., Westi, Emil Winther, Mouhammad, Zaynab Ahmad, Andersen, Jens Velde, Freude, Kristine, Vohra, Rupali, Hannibal, Jens, Aldana, Blanca & Kolko, Miriam, 2022, In: Cellular and Molecular Neurobiology. 42, 1, p. 291–303Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex
Westi, Emil Winther, Jakobsen, Emil, Voss, C. M., Bak, Lasse Kristoffer, Pinborg, Lars Hageman, Aldana, Blanca & Andersen, J. V., 2022, In: Molecular Neurobiology. 59, p. 7495–7512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer’s Disease
Ameen, Aisha, Freude, Kristine & Aldana, Blanca, 2022, In: Biomedicines. 10, 11, 2778.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants
Vohra, Rupali, Sanz-Morello, B., Tams, A. L. M., Mouhammad, Zaynab Ahmad, Freude, Kristine, Hannibal, Jens, Aldana, Blanca, Bergersen, L. H. & Kolko, Miriam, 2022, In: Cells. 11, 13, 2098.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes
Ilieva, M., Aldana, Blanca, Vinten, K. T., Hohmann, S., Woofenden, T. W., Lukjanska, R., Waagepetersen, Helle S. & Michel, T. M., 2022, In: Molecular Psychiatry. 27, p. 3749–3759Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes
Schousboe, Arne & Aldana, Blanca, 29 Jul 2021, Encyclopedia of Biological Chemistry: Third Edition. Elsevier, Vol. 1. p. 51-55 5 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
Andersen, Jens Velde, Westi, Emil Winther, Jakobsen, Emil, Urruticoechea, N., Borges, K. & Aldana, Blanca, 2021, In: Molecular Brain. 14, 1, 13 p., 132.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3
Chandrasekaran, A., Dittlau, K. S., Corsi, G. I., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Zhang, Y., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J. E., Kolko, M., Kobolák, J., Dinnyés, A., Hyttel, P., Palakodeti, D. & 5 others, , 2021, In: Stem Cell Reports. 16, 11, p. 2736-2751Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions
Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease
Aldana, Blanca, Salcedo, C., Freude, Kristine & Waagepetersen, Helle S., 2021, Current Progress in iPSC-derived Cell Types. Birbrair, A. (ed.). Elsevier, p. 205-221 17 p. (Advances in Stem Cell Biology, Vol. 10).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, Jens Velde, Christensen, S. K., Westi, Emil Winther, Diaz-delcastillo, M., Tanila, H., Schousboe, Arne, Aldana, Blanca & Waagepetersen, Helle S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Wagner, A., Andersen, Jens Velde, Vinten, K. T., Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine & Aldana, Blanca, 2021, In: Neurochemical Research. 46, p. 2676–2686Research output: Contribution to journal › Journal article › Research › peer-review
ID: 183889241
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Microglia-Specific Metabolic Changes in Neurodegeneration
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
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Lactate-Mediated Protection of Retinal Ganglion Cells
Research output: Contribution to journal › Journal article › Research › peer-review
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