Blanca Aldana
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2021
- Published
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.Research output: Contribution to journal › Review › Research › peer-review
- Published
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose
Pawlik, M. J., Aldana, Blanca, Belfiori-Carrasco, L. F., Obara-Michlewska, M., Popek, M. P., Czarnecka, A. M. & Albrecht, J., 2021, In: International Journal of Molecular Sciences. 22, 20, 16 p., 11127.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
Rimmele, T. S., Li, S., Andersen, Jens Velde, Westi, Emil Winther, Rotenberg, A., Wang, J., Aldana, Blanca, Selkoe, D. J., Aoki, C. J., Dulla, C. G. & Rosenberg, P. A., 2021, In: Frontiers in Cellular Neuroscience. 15, 788262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function
Sanz-Morello, B., Pfisterer, U., Hansen, Nikolaj Winther, Demharter, S., Thakur, A., Fujii, K., Levitskii, S. A., Montalant, A., Korshunova, Irina, Mammen, P. P., Kamenski, P., Noguchi, S., Aldana, Blanca, Hougaard, Karin Sørig, Perrier, Jean-Francois Marie & Khodosevich, Konstantin, 2020, In: The EMBO Journal. 39, 18, p. 1-21 e105759.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
McNair, Laura M., Andersen, Jens Velde, Nissen, J. D., Sun, Y., Fischer, K. D., Hodgson, N. W., Du, M., Aoki, C. J., Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2020, In: Neurochemical Research. 45, p. 1420–1437 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Møller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana, Blanca, Desler, Claus, Rasmussen, Lene Juel, Sustarsic, E. G., Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In: Frontiers in Immunology. 11, 22 p., 1968.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex
Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia
Aldana, Blanca, Zhang, Y., Jensen, P., Chandrasekaran, Abinaya, Christensen, S. K., Nielsen, T. T., Nielsen, Jørgen Erik, Hyttel, P., Larsen, M. R., Waagepetersen, Helle S. & Freude, Kristine, 2020, In: Molecular Brain. 13, 1, 7 p., 125.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation in FTD3 CHMP2B causes impaired autography and distorted energy metabolism cumulating in reactive astrocyte phenotypes
Chandrasekaran, A., Dittlau, K. S., Corsi, G., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, , 2020.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Mutations in FTD3 CHMP2B causes impaired autophagy and distorted energy metabolism cumulating in reactive astrocyte phenotypes
Chandrasekaran, A., Dittlau, K. S., Corsi, G., Doncheva, N. T., Haukedal, H., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, , 2020.Research output: Contribution to conference › Poster › Research
- 2019
- Published
Lactate-Mediated Protection of Retinal Ganglion Cells
Vohra, Rupali, Aldana, Blanca, Bulli, G., Jensen, Dorte Skytt, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1878-1888 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microglia-Specific Metabolic Changes in Neurodegeneration
Aldana, Blanca, 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1830-1842Research output: Contribution to journal › Review › Research › peer-review
- Published
Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.Research output: Contribution to conference › Poster › Communication
- Published
Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation
Vohra, Rupali, Aldana, Blanca, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 1 Mar 2019, In: Investigative Ophthalmology & Visual Science. 60, 4, p. 999-1008 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function
McNair, Laura M., Andersen, Jens Velde, Aldana, Blanca, Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N., Webster, S. C., Kapur, K., Rimmele, T. S., Barone, I., Hawks-Mayer, H., Lipton, J. O., Hodgson, N. W., Aoki, C. J., Rosenberg, P. A. & Waagepetersen, Helle S., 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 25, p. 4847-4863Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria
Andersen, Jens Velde, Jakobsen, Emil, Waagepetersen, Helle S. & Aldana, Blanca, 2019, In: Journal of Neuroscience Research. 97, p. 961–974Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease
Andersen, Jens Velde, Skotte, Niels Henning, Aldana, Blanca, Nørremølle, Anne & Waagepetersen, Helle S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line
Schmid, B., Prehn, K. R., Nimsanor, N., Aldana, Blanca, Poulsen, U., Jorring, I., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Ramakrishna, S., Muddashetty, R., Steeg, R., Bruce, K., Mackintosh, P., Ebneth, A., Holst, B. & Cabrera-Socorro, A., 2019, In: Stem Cell Research. 34, 6 p., 101349.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Glutamate homeostasis revisited - neuronal transport and metabolism
Waagepetersen, Helle S., McNair, Laura M., Christensen, S. K., Andersen, Jens Velde & Aldana, Blanca, 2019, p. 19-19.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2018
- Published
Essential Roles of Lactate in Müller Cell Survival and Function
Vohra, Rupali, Aldana, Blanca, Jensen, Dorte Skytt, Freude, Kristine, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 1 Dec 2018, In: Molecular Neurobiology. 55, 12, p. 9108-9121 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 183889241
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1009
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Microglia-Specific Metabolic Changes in Neurodegeneration
Research output: Contribution to journal › Review › Research › peer-review
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461
downloads
Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
417
downloads
Lactate-Mediated Protection of Retinal Ganglion Cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published