Blanca Aldana
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- Published
Potential Retinal Biomarkers in Alzheimer's Disease
Garcia Bermudez, Mariana Yolotzin, Vohra, Rupali, Freude, Kristine, van Wijngaarden, P., Martin, K. K., Thomsen, M. S., Aldana, Blanca & Kolko, Miriam, 2023, In: International Journal of Molecular Sciences (Online). 24, 21, 26 p., 15834.Research output: Contribution to journal › Review › Research › peer-review
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Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3
Haukedal, H., Syshøj Lorenzen, S., Westi, Emil Winther, Corsi, G., Gadekar, V. P., McQuade, A., Davtyan, H., Doncheva, Nadezhda Tsankova, Schmid, B., Chandrasekaran, Abinaya, Seemann, Ernst Stefan, Cirera, Susanna, Blurton-Jones, M., Meyer, M., Gorodkin, Jan, Aldana, Blanca & Freude, Kristine, 2023, In: Brain, Behavior, and Immunity. 113, p. 353-373Research output: Contribution to journal › Journal article › Research › peer-review
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Golgi fragmentation: One of the earliest organelle phenotypes in Alzheimer's disease neurons
Haukedal, H., Corsi, G. I., Gadekar, V. P., Doncheva, N. T., Kedia, S., de Haan, N., Chandrasekaran, A., Jensen, P., Schiønning, P., Vallin, S., Marlet, F. R., Poon, A., Pires, C., Agha, F. K., Wandall, H. H., Cirera, S., Simonsen, A. H., Nielsen, T. T., Nielsen, J. E., Hyttel, P. & 7 others, , 2023, In: Frontiers in Neuroscience. 17, 17 p., 1120086.Research output: Contribution to journal › Journal article › Research › peer-review
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Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.Research output: Contribution to conference › Conference abstract for conference › Research
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Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.Research output: Contribution to conference › Poster › Communication
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Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model
Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758Research output: Contribution to journal › Journal article › Research › peer-review
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Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions
Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes
Ilieva, M., Aldana, Blanca, Vinten, K. T., Hohmann, S., Woofenden, T. W., Lukjanska, R., Waagepetersen, Helle S. & Michel, T. M., 2022, In: Molecular Psychiatry. 27, p. 3749–3759Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
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Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma
Lewinska, M., Zhuravleva, E., Satriano, L., Martinez, M. B., Bhatt, D. K., Oliveira, D. V. N. P., Antoku, Y., Keggenhoff, F. L., Castven, D., Marquardt, J. U., Matter, M. S., Erler, J. T., Oliveira, R. C., Aldana, B. I., Al-Abdulla, R., Perugorria, M. J., Calvisi, D. F., Perez, L. A., Rodrigues, P. M., Labiano, I. & 2 others, , 2023, In: Gastroenterology. 166, 5, p. 886-901Research output: Contribution to journal › Journal article › Research › peer-review
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The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.Research output: Contribution to journal › Journal article › Research › peer-review
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Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function
McNair, Laura M., Andersen, Jens Velde, Aldana, Blanca, Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N., Webster, S. C., Kapur, K., Rimmele, T. S., Barone, I., Hawks-Mayer, H., Lipton, J. O., Hodgson, N. W., Aoki, C. J., Rosenberg, P. A. & Waagepetersen, Helle S., 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 25, p. 4847-4863Research output: Contribution to journal › Journal article › Research › peer-review
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Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
McNair, Laura M., Andersen, Jens Velde, Nissen, J. D., Sun, Y., Fischer, K. D., Hodgson, N. W., Du, M., Aoki, C. J., Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2020, In: Neurochemical Research. 45, p. 1420–1437 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821Research output: Contribution to journal › Journal article › Research › peer-review
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Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Møller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana, Blanca, Desler, Claus, Rasmussen, Lene Juel, Sustarsic, E. G., Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In: Frontiers in Immunology. 11, 22 p., 1968.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose
Pawlik, M. J., Aldana, Blanca, Belfiori-Carrasco, L. F., Obara-Michlewska, M., Popek, M. P., Czarnecka, A. M. & Albrecht, J., 2021, In: International Journal of Molecular Sciences. 22, 20, 16 p., 11127.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
Rimmele, T. S., Li, S., Andersen, Jens Velde, Westi, Emil Winther, Rotenberg, A., Wang, J., Aldana, Blanca, Selkoe, D. J., Aoki, C. J., Dulla, C. G. & Rosenberg, P. A., 2021, In: Frontiers in Cellular Neuroscience. 15, 788262.Research output: Contribution to journal › Journal article › Research › peer-review
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Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Wagner, A., Andersen, Jens Velde, Vinten, K. T., Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine & Aldana, Blanca, 2021, In: Neurochemical Research. 46, p. 2676–2686Research output: Contribution to journal › Journal article › Research › peer-review
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Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Andersen, Jens Velde, Vinten, K. T., Pinborg, Lars Hageman, Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2021, In: Frontiers in Aging Neuroscience. 13, 736580.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease
Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, Aisha, Gegelashvili, G., Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
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Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function
Sanz-Morello, B., Pfisterer, U., Hansen, Nikolaj Winther, Demharter, S., Thakur, A., Fujii, K., Levitskii, S. A., Montalant, A., Korshunova, Irina, Mammen, P. P., Kamenski, P., Noguchi, S., Aldana, Blanca, Hougaard, Karin Sørig, Perrier, Jean-Francois Marie & Khodosevich, Konstantin, 2020, In: The EMBO Journal. 39, 18, p. 1-21 e105759.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line
Schmid, B., Prehn, K. R., Nimsanor, N., Aldana, Blanca, Poulsen, U., Jorring, I., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Ramakrishna, S., Muddashetty, R., Steeg, R., Bruce, K., Mackintosh, P., Ebneth, A., Holst, B. & Cabrera-Socorro, A., 2019, In: Stem Cell Research. 34, 6 p., 101349.Research output: Contribution to journal › Editorial › Research › peer-review
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Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes
Schousboe, Arne & Aldana, Blanca, 29 Jul 2021, Encyclopedia of Biological Chemistry: Third Edition. Elsevier, Vol. 1. p. 51-55 5 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs
Sitges, M., Sanchez-Tafolla, B. M., Chiu, L. M., Aldana, Blanca & Guarneros, A., Oct 2011, In: Epilepsy Research. 96, 3, p. 257-266 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 183889241
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1009
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Microglia-Specific Metabolic Changes in Neurodegeneration
Research output: Contribution to journal › Review › Research › peer-review
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461
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Research output: Contribution to journal › Journal article › Research › peer-review
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417
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Lactate-Mediated Protection of Retinal Ganglion Cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published