Christian Adam Olsen

Christian Adam Olsen

Professor

ORCID: 0000-0002-2953-8942

Publication year:
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51 - 100 out of 113Page size: 50
  1. 2016
  2. Published

    Innovative Strategies for Selective Inhibition of Histone Deacetylases

    Maolanon, A. R., Madsen, A. S. & Olsen, Christian Adam, 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 759-768 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Optoepigenetics: An acetylation photoswitch

    Madsen, A. S. & Olsen, Christian Adam, May 2016, In: Nature Chemical Biology. 12, 5, p. 306-7 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH

    Madsen, A. S., Andersen, C., Daoud, M., Anderson, K. A., Laursen, J. S., Chakladar, S., Huynh, F. K., Colaco, A. R., Backos, D. S., Fristrup, P., Hirschey, M. D. & Olsen, Christian Adam, 25 Mar 2016, In: Journal of Biological Chemistry. 291, 13, p. 7128-7141 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

    Galleano, I., Schiedel, M., Jung, M., Madsen, A. S. & Olsen, Christian Adam, 11 Feb 2016, In: Journal of Medicinal Chemistry. 59, 3, p. 1021-31 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action

    Madsen, A. S. & Olsen, Christian Adam, 2016, In: MedChemComm. 7, p. 464-470 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

    Canovas de la Nuez, J., Baldry, M., Bojer, Martin Saxtorph, Andersen, P. S., Grzeskowiak, P. K., Stegger, M., Damborg, Peter Panduro, Olsen, Christian Adam & Ingmer, Hanne, 2016, In: Frontiers in Microbiology. 7, 1733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions

    Baldry, M., Kitir, B., Frøkiær, Hanne, Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, Henrik, Olsen, Christian Adam, Wells, J. M. & Ingmer, Hanne, 2016, In: P L o S One. 11, 1, 17 p., e0145618.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2015
  10. Published

    β-Peptoid Foldamers at Last

    Laursen, J. S., Engel-Andreasen, J. & Olsen, Christian Adam, 20 Oct 2015, In: Accounts of Chemical Research. 48, 10, p. 2696-704 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Effects of Thionation and Fluorination on Cis-Trans Isomerization in Tertiary Amides: An Investigation of N-Alkylglycine (Peptoid) Rotamers

    Engel-Andreasen, J., Wich, K., Laursen, J. S., Harris, P. & Olsen, Christian Adam, 4 Mar 2015, In: Journal of Organic Chemistry. 80, 11, p. 5415–5427 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

    Laursen, J. S., Harris, Pernille, Fristrup, P. & Olsen, Christian Adam, 2015, In: Nature Communications. 6, p. 1-10 10 p., 7013.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2014
  14. Published

    An azumamide C analogue without the zinc-binding functionality

    Villadsen, J. S., Kitir, B., Wich, K., Friis, T., Madsen, A. S. & Olsen, Christian Adam, 12 Aug 2014, In: MedChemComm. 5, p. 1849-1855

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

    Tan, M., Peng, C., Anderson, K. A., Xie, Z., Chhoy, P., Dai, L., Park, J., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G. R., Green, M. F., Madsen, A. S., Schmiesing, J., Peterson, B. S., Xu, G., Ilkayeva, O. R., Muehlbauer, M. J., Braulke, T. & 8 others, Mühlhausen, C., Backos, D. S., Olsen, Christian Adam, McGuire, P. J., Pletcher, S. D., Lombard, D. B., Hirschey, M. D. & Zhao, Y., 1 Apr 2014, In: Cell Metabolism. 19, 4, p. 605–617

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    An Update on Lysine Deacylases Targeting the Expanding "Acylome"

    Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 434-437 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1-11

    Madsen, A. S., Kristensen, H. M. E., Lanz, A. G. & Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 614-626 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

    Andreev, K., Bianchi, C., Laursen, J. S., Citterio, L., Hein-Kristensen, L., Gram, L., Kuzmenko, I., Olsen, Christian Adam & Gidalevitz, D., 2014, In: B B A - Biomembranes. 1838, 10, p. 2492-502 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles

    Maolanon, A. R., Villadsen, J. S., Christensen, Niels Johan, Hoeck, C., Friis, T., Harris, P., Gotfredsen, C. H., Fristrup, P. & Olsen, Christian Adam, 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9644-9657 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2013
  21. Published

    Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A-E as Well as beta(2)- epi-Azumamide E and beta(3)-epi-Azumamide E

    Villadsen, J., Stephansen, H. M., Maolanon, A. R., Harris, Pernille & Olsen, Christian Adam, 22 Aug 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6512-6520

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Cis-Trans Amide Bond Rotamers in beta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains

    Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, Pernille & Olsen, Christian Adam, 20 Feb 2013, In: Journal of the American Chemical Society. 135, 7, p. 2835-2844

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2012
  24. Published

    Macrocyclic Peptoid-Peptide Hybrids as Inhibitors of Class I Histone Deacetylases

    Olsen, Christian Adam, Montero, A., Leman, L. J. & Ghadiri, M. R., Sep 2012, In: ACS Medicinal Chemistry Letters. 3, 9, p. 749-753

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme

    Madsen, A. S. & Olsen, Christian Adam, 14 Jun 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5582-5590

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

    Vickers, C. J., Olsen, Christian Adam, Leman, L. J. & Ghadiri, M. R., Jun 2012, In: ACS Medicinal Chemistry Letters. 3, 6, p. 505-508

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Expansion of the Lysine Acylation Landscape

    Olsen, Christian Adam, 2012, In: Angewandte Chemie International Edition. 51, 16, p. 3755-3756

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Profiling of Substrates for Zinc-dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

    Olsen, Christian Adam & Madsen, A., 2012, In: Angewandte Chemie International Edition. 51, 36, p. 9083-9087

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives

    Hansen, A. N., Bendiksen, C. D., Sylvest, L., Friis, T., Stærk, Dan, Jørgensen, Flemming Steen, Olsen, Christian Adam & Houen, G., 2012, In: P L o S One. 7, 9, 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2011
  31. Published

    Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of Delta F508-CFTR

    Hutt, D. M., Olsen, Christian Adam, Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E. & Ghadiri, M. R., Sep 2011, In: ACS Medicinal Chemistry Letters. 2, 9, p. 703-707

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Conformationally rigid histone deacetylase inhibitors correct DF508-CFTR protein function

    Vickers, C. J., Olsen, Christian Adam, Hutt, D. M., Montero, A., Leman, L. J., Maryanoff, B. E., Balch, W. E. & Ghadiri, M. R., 28 Aug 2011, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 242

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    β-peptoid “Foldamers”-Why the additional methylene unit?

    Olsen, Christian Adam, 1 Jan 2011, In: Biopolymers. 96, 5, p. 561-566 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. 2010
  35. Published

    Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  36. Published

    Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Peptoid-Peptide hybrid backbone architectures

    Olsen, Christian Adam, 25 Jan 2010, In: ChemBioChem. 11, 2, p. 152-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. 2009
  40. Published

    Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic alpha(3)beta-Tetrapeptides

    Olsen, Christian Adam & Ghadiri, M. R., 10 Dec 2009, In: Journal of Medicinal Chemistry. 52, 23, p. 7836-7846

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures

    Montero, A., Beierle, J. M., Olsen, Christian Adam & Ghadiri, M. R., 4 Mar 2009, In: Journal of the American Chemical Society. 131, 8, p. 3033-3041

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

    Horne, W. S., Olsen, Christian Adam, Beierle, J. M., Montero, A. & Ghadiri, M. R., 2009, In: Angewandte Chemie International Edition. 48, 26, p. 4718-4724

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

    Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2008
  45. Published

    Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides

    Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Dimeric Building Blocks for Solid-Phase Synthesis of α-Peptide-β-Peptoid Chimeras

    Seigan, G. B., Vedel, L., Matthias, W., Jaroszewski, J. W., Olsen, Christian Adam & Franzyk, Henrik, 2008, In: Synthesis. 2008, 15, p. 2381-2390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers

    Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 2007
  49. Published

    Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras

    Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Aziridines in parallel- and solid-phase synthesis

    Olsen, Christian Adam, Bonke, G., Vedel, L., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: European Journal of Organic Chemistry. 2007, 11, p. 1717-1724

    Research output: Contribution to journal › Review › Research › peer-review

  51. Published

    Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker

    Olsen, Christian Adam, Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Tetrahedron Letters. 48, 3, p. 405-408

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    α-Peptide/ß-Peptoid Chimeras

    Olsen, Christian Adam, Bonke, G., Vedel, L., Adsersen, A., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Organic Letters. 9, 8, p. 1549–1552 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2006
  54. Published

    Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid lamellarin D

    Pla, D., Marchal, A., Olsen, Christian Adam, Francesch, A., Cuevas, C., Albericio, F. & Alvarez, M., 1 Jun 2006, In: Journal of Medicinal Chemistry. 49, 11, p. 3257-3268 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Kunstige forsvarspeptider

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Lægemiddelforskning. p. 18-19 2 p.

    Research output: Contribution to journal › Journal article › Communication

  57. Published

    Nanomolær inhibering med hvepsetoksinanaloger – syntese og elektrofysiologi

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Dansk Kemi. 87, p. 23-26 4 p.

    Research output: Contribution to journal › Journal article › Communication

  58. Published

    Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy

    Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers

    Olsen, Christian Adam, Mellor, I. R., Wellendorph, Petrine, Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2006, In: ChemMedChem. 1, 3, p. 303-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. 2005
  61. Published

    Modular total synthesis of lamellarin D

    Pla, D., Marchal, A., Olsen, Christian Adam, Albericio, F. & Álvarez, M., 20 Sep 2005, In: Journal of Organic Chemistry. 70, 20, p. 8231-8234 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

    Olsen, Christian Adam, Parera, N., Albericio, F. & Álvarez, M., 21 Mar 2005, In: Tetrahedron Letters. 46, 12, p. 2041-2044 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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