Henrik Franzyk
Associate Professor
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Escherichia coli with resistance to α-peptide/β-peptoid peptidomimetics: Mutation of a gene related to structural changes of cell wall peptidoglycan
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2012.Research output: Contribution to conference › Poster › Research
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Adaptive Evolution of Escherichia coli to an α-Peptide/β-Peptoid Peptidomimetic Induces Stable Resistance
Hein-Kristensen, L., Franzyk, Henrik, Holch, A. & Gram, L., 2013, In: PLOS ONE. 8, 9, p. e73620Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains
Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In: B M C Microbiology. 11, 1, p. 144Research output: Contribution to journal › Journal article › Research › peer-review
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Linking activity and mode of action to length in a novel peptidomimetics library
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2010.Research output: Contribution to conference › Poster › Research
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Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
Hellewell, L., Gilani, N. M., Stanton, C. J., Pelligand, L., Franzyk, Henrik, Guardabassi, Luca & Good, L., 2022, In: Future Medicinal Chemistry. 14, 24, p. 1899–1921Research output: Contribution to journal › Review › Research › peer-review
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Peptidomimetics as novel formyl peptide receptor 2 (FPR2) modulators in human and mouse neutrophils
Holdfeldt, A., Dahlgren, C., Forsman, H., Skovbakke, S. L. & Franzyk, Henrik, 2016.Research output: Contribution to conference › Poster › Research
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Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function
Holdfeldt, A., Skovbakke, S. L., Gabl, M., Nielsen, C., Dahlgren, C., Franzyk, Henrik & Forsman, H., 28 Mar 2019, In: ACS Omega. 4, 3, p. 5968-5982 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil NADPH-oxidase
Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 291, 38, p. 19888-19899 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase
Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo
Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, Henrik, Lepenies, B., Christensen, D., Foged, Camilla & Lang, R., Aug 2016, In: Innate Immunity. 22, 6, p. 405-418 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of a proteolytically stable multifunctional host defense peptidomimetic
Jahnsen, R. D., Haney, E. F., Franzyk, Henrik & Hancock, R. E. W., 10 Oct 2013, In: Chemistry & Biology. 20, 10, p. 1286-1295 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli
Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones
Jahnsen, R. D., Frimodt-Møller, N. & Franzyk, Henrik, 2012, In: Journal of Medicinal Chemistry. 55, 16, p. 7253-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria
Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial Peptidomimetics
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2013.Research output: Contribution to conference › Poster › Research
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Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.Research output: Contribution to conference › Poster › Research
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Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48Research output: Contribution to journal › Journal article › Research › peer-review
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Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts
Jaroszewski, J. W., Olafsdottir, E. S., Wellendorph, Petrine, Christensen, J. L., Franzyk, Henrik, Somanadhan, B., Budnik, B. A., Jørgensen, L. B. & Clausen, V., 2002, In: Phytochemistry. 59, 5, p. 501-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Naravelia zeyanica: occurrence of primary benzamides in flowering plants
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H. & Franzyk, Henrik, 2005, In: Natural Product Research. 19, 3, p. 291-294Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: "Naravelia zeylanica: Occurrence of primary benzamides in flowering plants" (Natural Product Research vol. 19 (3) (291-294))
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H., Franzyk, Henrik & Somanadhan, B., 1 Jun 2005, In: Natural Product Research. 19, 4, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article › Communication
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Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation
Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position
Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.Research output: Contribution to journal › Journal article › Research › peer-review
Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers
Jensen, S. R., Franzyk, Henrik & Wallander, E., 2002, In: Phytochemistry. 60, 3, p. 213-31 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.
Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues
Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake
Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175Research output: Contribution to journal › Journal article › Research › peer-review
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Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group
Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109Research output: Contribution to journal › Conference abstract in journal › Research
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Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids
Jørgensen, Johan Storm, Harifi Mood, Elnaz, Knap, A. S. H., Nielsen, S. E., Nielsen, Peter E., Żabicka, D., Matias, C., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1370–1383Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism
Jørgensen, M., Olsen, Christian Adam, Mellor, I. R., Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2005, In: Journal of Medicinal Chemistry. 48, 1, p. 56-70 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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On-resin Carboxy Group Activation of ω-Amino Acids in Solid-Phase Synthesis of Philanthotoxin Analogues
Jørgensen, M. R., Jaroszewski, J. W., Witt, M. & Franzyk, Henrik, 2005, In: Synthesis. p. 2687-2694 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solution and Solid-Phase Synthesis of Philanthotoxin Analogues
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2002.Research output: Contribution to conference › Poster › Research
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Solid-phase Synthesis of Philanthotoxin Analogues with Modified and Elongated Polyamine Chains
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003.Research output: Contribution to conference › Poster › Research
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Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition
Kachel, H. S., Patel, R. N., Franzyk, Henrik & Mellor, I. R., 30 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 38116.Research output: Contribution to journal › Journal article › Research › peer-review
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Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency
Kachel, H. S., Franzyk, Henrik & Mellor, I. R., 11 Jul 2019, In: Journal of Medicinal Chemistry. 62, 13, p. 6214-6222Research output: Contribution to journal › Journal article › Research › peer-review
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Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins
Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.Research output: Contribution to journal › Journal article › Research
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Does the molecular structure of mono and diester analogues of trehalose-6,6’-dibehenate (TDB) influence the biophysical chracteristics and receptor interaction with Mincle ?
Kallerup, R. S., Martin-Bertelsen, Birte, Franzyk, Henrik, Korsholm, K. S., Huber, A., Lang, R. & Foged, Camilla, 2014. 1 p.Research output: Contribution to conference › Poster › Research
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Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes
Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA
Kallerup, R. S., Franzyk, Henrik, Schiøth, M. L., Justesen, S., Martin-Bertelsen, Birte, Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, Anan & Foged, Camilla, 12 May 2017, In: Molecular Pharmaceutics. 14, 7, p. 2294-2306 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of synthesis and antibacterial activity of a- and ß-peptoids
Knapp, K. M., Franzyk, Henrik & Jahnsen, R., 2010. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation
Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation
Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid Glycoside Biosynthesis in Penstemon Secundiflorus. Another H-5,H-9 Trans-Iridoid Glycoside
Krull, R. E., Stermitz, F. R., Franzyk, Henrik & Jensen, S. R., 1998, In: Phytochemistry. 49, p. 1605-1608 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii
Larsen, C. E., Larsen, C. J., Franzyk, Henrik & Regenberg, Birgitte, 2015, In: F E M S Yeast Research. 15, 3, 8 p., fov011.Research output: Contribution to journal › Journal article › Research › peer-review
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UV-guided Isolation of Verrucine A and B, novel Quinazolines from Penicillium verrucosum Structurally Related to Anacine from P. aurantiogriseum
Larsen, T. O., Franzyk, Henrik & Jensen, S. R., 1999, In: Journal of Natural Products. 62, 11, p. 1578-1580 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.Research output: Contribution to journal › Journal article › Research › peer-review
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High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum effect of antimicrobial peptides
Loffredo, M. R., Savini, F., Bobone, S., Casciaro, B., Franzyk, Henrik, Mangoni, M. L. & Stella, L., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 21, 10 p., e2014364118.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles
Lokras, Abhijeet, Thakur, A., Wadhwa, A., Thanki, K., Franzyk, Henrik & Foged, Camilla, 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.Research output: Contribution to journal › Journal article › Research › peer-review
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Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems
Lokras, Abhijeet, Chakravarty, A., Rades, Thomas, Christensen, D., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.Research output: Contribution to journal › Journal article › Research › peer-review
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The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria
Luck, V. L., Richards, D. P., Shaikh, Ashif Yasin, Franzyk, Henrik & Mellor, I. R., 2021, In: Molecules (Print Archive Edition). 26, 22, 11 p., 7007.Research output: Contribution to journal › Journal article › Research › peer-review
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Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli
Ma, Y., Pirolo, Mattia, Subramani, P., Gehring, R., Damborg, Peter Panduro, Franzyk, Henrik & Guardabassi, Luca, 2022, In: mSphere. 7, 5, 10 p., e0040222.Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysical and nanostructural properties of trehalose 6-mono and 6,6’-diesters
Madsen, C. M., Martin-Bertelsen, Birte, Kallerup, R. S., Rose, F., Christensen, D., Yaghmur, Anan, Franzyk, Henrik & Foged, Camilla, 2015. 1 p.Research output: Contribution to conference › Poster › Research
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Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens
Malik, A., Ardalani, H., Anam, S., McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Fitoterapia. 142, 8 p., 104522.Research output: Contribution to journal › Journal article › Research › peer-review
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Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers
Martin-Bertelsen, Birte, Yaghmur, Anan, Franzyk, Henrik, Justesen, S., Kirkensgaard, Jacob Judas Kain & Foged, Camilla, 7 Nov 2016, In: Langmuir. 32, 48, p. 12693–12701 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The supramolecular structure is decisive for the immunostimulatory properties of synthetic analogues of a mycobacterial lipid in vitro
Martin-Bertelsen, Birte, Korsholm, K. S., Rose, F., Nordly, P. J., Franzyk, Henrik, Andersen, P., Agger, E. M., Christensen, D., Yaghmur, Anan & Foged, Camilla, 2013, In: R S C Advances. 3, 43, p. 20673-20683Research output: Contribution to journal › Journal article › Research › peer-review
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Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy
Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2016, In: Molecular Pharmaceutics. 13, 8, p. 2771-2781 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures
McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.Research output: Contribution to journal › Journal article › Research › peer-review
Recent techniques in Glycopeptide synthesis and biology: the glycopeptide templates
Meldal, M., Franzyk, Henrik, Meinjohanns, E., Vargas-Berenguel, A., Frische, K., Christensen, M. K., Christensen, I. B., Jensen, K. J. & Bock, K., 1997, Innovations and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Kingswinford: Mayflower Scientific, p. 263-268 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Multiple Column Synthesis of Glycopeptide Libraries in the Characterization of Receptor Interaction with Glycopeptide Ligands
Meldal, M., Frische, K., Meinjohanns, E., Christensen, M. K., Franzyk, Henrik, Jensen, T., Werdelin, O., Galli-Stampino, L., Mouritsen, S. & Cordes, H., 1996, In: Abstract Papers Am. Chem. Soc.. 212, p. 26-ORGNResearch output: Contribution to journal › Journal article › Research
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Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress
Mohamad, M. H. N., Abu, I. F., Fazel, M. F., Agarwal, R., Iezhitsa, I., Juliana, N., Mellor, I. R. & Franzyk, Henrik, 2021, In: Frontiers in Pharmacology. 12, 11 p., 798794.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.Research output: Contribution to conference › Poster › Research
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Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.Research output: Contribution to journal › Journal article › Research › peer-review
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Advances in development of antimicrobial peptidomimetics as potential drugs
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.Research output: Contribution to journal › Review › Research › peer-review
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Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic
Harifi Mood, Elnaz, Goltermann, Lise, Brolin, C., Cavaco, L. M., Japoni Nejad, Alireza, Yavari, Niloofar, Frederiksen, N., Franzyk, Henrik & Nielsen, Peter E., 2021, In: ACS Infectious Diseases. 7, 8, p. 2152–2163Research output: Contribution to journal › Journal article › Research › peer-review
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Antimikrobielle peptider: et nyt våben mod multiresistente bakterier
Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11Research output: Contribution to journal › Journal article › Communication
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Quantification of pharmaceutical peptides using selenium as an elemental detection label
Møller, L. H., Gabel-Jensen, C., Franzyk, Henrik, Bahnsen, J. S., Stürup, Stefan & Gammelgaard, Bente, 16 Jul 2014, In: Metallomics : integrated biometal science. 6, p. 1639-1647 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers
Nielsen, Hanne Mørck, Jing, X., Simonsen, A., Kasimova, M. R., Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2010, In: Journal of Peptide Science. 16, s1, p. 151 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Antisense PNA antibiotics against multiresistant Gram-negative bacteria
Nielsen, Peter E., Björkling, Fredrik & Franzyk, Henrik, 2017, In: International Journal of Molecular Medicine. 40, Suppl. 1, p. S22 1 p., Abstract 169.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A synthetic mycobacterial monomycoloyl glycerol analogue stabilizes DDA liposomes
Nordly, P. J., Pedersen, E. A., Khiljii, T. S., Agger, E. M., Jørgensen, Lene, Nielsen, Hanne Mørck, Korsholm, K. S., Franzyk, Henrik & Foged, Camilla, 2010, In: CRS Newsletter. 27, 2, p. 12 14 p.Research output: Contribution to journal › Journal article › Research
- Published
An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action
Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis
Olsen, Christian Adam, Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Organic Letters. 7, 9, p. 1703-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expedient protocol for solid-phase synthesis of secondary and tertiary amines
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Organic Letters. 6, 12, p. 1935-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Journal of Organic Chemistry. 69, 18, p. 6149-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers
Olsen, Christian Adam, Mellor, I. R., Wellendorph, Petrine, Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2006, In: ChemMedChem. 1, 3, p. 303-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase polyamine synthesis using piperazine and piperidine building blocks
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: Organic Letters. 5, 22, p. 4183-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
N-Alkylation Reactions and Indirect Formation of Amino Functionalities in Solid-Phase Synthesis
Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Synthesis. p. 2631-2653 23 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New Linker Strategies in SPS of Neuroactive Wasp Toxin Analogues
Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2005.Research output: Contribution to conference › Poster › Research
- Published
Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker
Olsen, Christian Adam, Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Tetrahedron Letters. 48, 3, p. 405-408Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanomolær inhibering med hvepsetoksinanaloger – syntese og elektrofysiologi
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Dansk Kemi. 87, p. 23-26 4 p.Research output: Contribution to journal › Journal article › Communication
- Published
Kunstige forsvarspeptider
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Lægemiddelforskning. p. 18-19 2 p.Research output: Contribution to journal › Journal article › Communication
- Published
Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins
Olsen, Christian Adam, Witt, M., Hansen, S. H., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Tetrahedron. 61, p. 6046-6055 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aziridines in parallel- and solid-phase synthesis
Olsen, Christian Adam, Bonke, G., Vedel, L., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: European Journal of Organic Chemistry. 2007, 11, p. 1717-1724Research output: Contribution to journal › Review › Research › peer-review
- Published
Hurtige genveje til nye lægemidler
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2003, In: Lægemiddelforskning. 2003, p. 8-9 2 p.Research output: Contribution to journal › Journal article › Communication
- Published
Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers
Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471Research output: Contribution to journal › Journal article › Research › peer-review
- Published
α-Peptide/ß-Peptoid Chimeras
Olsen, Christian Adam, Bonke, G., Vedel, L., Adsersen, A., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Organic Letters. 9, 8, p. 1549–1552 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. p. 473-476 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Choice of Phosphane Reagent in Fukuyama-Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of Philanthotoxins
Olsen, Christian Adam, Jørgensen, M. R., Witt, M., Mellor, I. R., Usherwood, P. N. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: European Journal of Organic Chemistry. p. 3288-3299 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
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2002
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1600
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
Published -
1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published