Henrik Franzyk

Henrik Franzyk

Associate Professor

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    ORCID: 0000-0002-2822-1927

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    1. Published

      Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

      de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Phorbol Rearrangements

      Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues

      Ziegler, H. L., Franzyk, Henrik, Sairafianpour, M., Tabatabai, M., Tehrani, M. D., Bagherzadeh, K., Hägerstrand, H., Stærk, Dan & Jaroszewski, J. W., 2004, In: Bioorganic & Medicinal Chemistry. 12, p. 119-127

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency

      Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

      Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA

      Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research

    8. Published

      Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies

      Xu, Y., Cañadas, O., Alonso, A., Franzyk, Henrik, Thakur, A., Pérez-gil, J. & Foged, Camilla, 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability

      Xu, You, Turan, E. T., Shi, Z., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

      Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, Henrik, Pérez-Gil, J., Malmsten, Martin & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

      Xu, Y., Harinck, L., Lokras, Abhijeet, Gerde, P., Selg, E., Sjöberg, C., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation

      Wu, B. C., Skovbakke, S. L., Masoudi, H., Hancock, R. E. W. & Franzyk, Henrik, 2020, In: Frontiers in Immunology. 11, 11 p., 2102.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation

      Wester, A., Björkling, Fredrik & Franzyk, Henrik, 2021, In: The Journal of Organic Chemistry. 86, 21, p. 14371–14380

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods

      Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, In: Amino Acids. 53, p. 1455–1466

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif

      Wester, A., Björkling, Fredrik, Nieslen, P. & Franzyk, Henrik, Sep 2018, In: Journal of Peptide Science. 24, p. S94-S94

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    16. Published

      A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

      Wellendorph, Petrine, Jaroszewski, J. W., Hansen, S. H. & Franzyk, Henrik, 2003, In: European Journal of Medicinal Chemistry. 38, 1, p. 117-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

      Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line

      Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    19. Published

      Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics

      Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    20. Published

      Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

      Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size

      Wadhwa, A., Bobak, T. R., Bohrmann, L., Geczy, R., Sekar, S., Sathyanarayanan, G., Kutter, Jörg P., Franzyk, Henrik, Foged, Camilla, Saatchi, K. & Häfeli, U. O., 2023, In: OpenNano. 13, 12 p., 100180.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics

      Vinther, J. M., Garrigues, C., Nyberg, N., Jäger, A., Franzyk, Henrik & Stærk, Dan, 2014.

      Research output: Contribution to conference › Poster › Research

    23. Published

      Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation.

      Viklund, M., Fredriksson, J., Holdfeldt, A., Lind, S., Franzyk, Henrik, Dahlgren, C., Sundqvist, M. & Forsman, H., 2022, In: Journal of Immunology. 208, 7, p. 1632-1641

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Peptide/β-Peptoid Hybrids with Activity against Vancomycin-Resistant Enterococci: Influence of Hydrophobicity and Structural Features on Antibacterial and Hemolytic Properties

      Vestergaard, M., Skive, Bolette, Domraceva, I., Ingmer, Hanne & Franzyk, Henrik, 2021, In: International Journal of Molecular Sciences. 22, 11, 5617.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras

      Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

      Thanki, K., Papai, S., Lokras, Abhijeet, Rose, F., Falkenberg, E., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 3, 37.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs

      Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Poster › Research

    28. Published

      Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

      Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

      Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.

      Research output: Contribution to conference › Poster › Research

    30. Published

      Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

      Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

      Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    32. Published

      Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins

      Thakur, A., Wadhwa, A., Lokras, Abhijeet, Amanda Oest Müllertz, O., Christensen, D., Franzyk, Henrik & Foged, Camilla, 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

      Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

      Tandrup Schmidt, S., Line Olsen, C., Franzyk, Henrik, Wørzner, K., Smith Korsholm, K., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 140, p. 29-39 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity

      Sæbø, I. P., Bjørås, M., Franzyk, Henrik, Helgesen, E. & Booth, J. A., 2023, In: International Journal of Molecular Sciences. 24, 3, 20 p., 2914.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

      Sundqvist, M., Holdfeldt, A., Wright, S. C., Møller, T. C., Siaw, E., Jennbacken, K., Franzyk, Henrik, Bouvier, M., Dahlgren, C. & Forsman, H., 2020, In: B B A - Molecular Cell Research. 1867, 12, 13 p., 118849.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Moderne naturstofkemi: effektiv analyse af naturens stofbiblioteker

      Stærk, Dan, Lemmich, E., Franzyk, Henrik, Lemmich, J. & Jaroszewski, J. W., 2000, In: Lægemiddelforskning. p. 6-7

      Research output: Contribution to journal › Journal article › Communication

    38. Published

      Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy

      Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides

      Steffensen, S. L., Møller, E. H., Franzyk, Henrik, Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    40. Published

      Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

      Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

      Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Silicone embedded nanogels for prolonged resistance against biofilm formation

      Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    43. Published

      Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization

      Skovbakke, S. L. & Franzyk, Henrik, 2017, Methods Molecular Biology: Antimicrobial Peptides. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 369-386 18 p. (Methods in Molecular Biology, Vol. 1548).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    44. Published

      A palmitoylated α-peptide/β-peptoid host defense peptide mimetic with potent anti-inflammatory activity

      Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research › peer-review

    45. Published

      The palmitoylated α-peptide/β-peptoid hybrid Pam-(Lys-βNSpe)6-NH2 is a novel host defense peptidomimetic with potent anti-inflammatory activity

      Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2014.

      Research output: Contribution to conference › Poster › Research

    46. Published

      The Proteolytically Stable Peptidomimetic Pam-(Lys-βNSpe)6-NH2 Selectively Inhibits Human Neutrophil Activation via Formyl Peptide Receptor 2

      Skovbakke, S. L., Heegaard, P. M. H., Larsen, C. J., Franzyk, Henrik, Forsman, H. & Dahlgren, C., 2015, In: Biochemical Pharmacology. 93, 2, p. 182-195 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils

      Skovbakke, S. L., Winther, M., Gabl, M., Holdfeldt, A., Linden, S., Wang, J. M., Dahlgren, C., Franzyk, Henrik & Forsman, H., 8 Sep 2016, In: Biochemical Pharmacology. 119, p. 56-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity

      Skovbakke, S. L., Larsen, C. J., Heegaard, P. M. H., Moesby, L. & Franzyk, Henrik, 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 801-813 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics

      Skovbakke, S. L., Holdfeldt , A., Forsman, H., Bylund, J. & Franzyk, Henrik, 2018, In: Current Pharmaceutical Design. 24, 10, p. 1100-1120 21 p.

      Research output: Contribution to journal › Review › Research › peer-review

    50. Published

      Combining elements from two antagonists of formyl peptide receptor 2 generates more potent peptidomimetic antagonists

      Skovbakke, S. L., Holdfeldt, A., Nielsen, C., Hansen, A. M., Perez-Gassol, I., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2017, In: Journal of Medicinal Chemistry. 60, 16, p. 6991-6997

      Research output: Contribution to journal › Journal article › Research › peer-review

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