Henrik Franzyk
Associate Professor
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Escherichia coli with resistance to α-peptide/β-peptoid peptidomimetics: Mutation of a gene related to structural changes of cell wall peptidoglycan
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2012.Research output: Contribution to conference › Poster › Research
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Adaptive Evolution of Escherichia coli to an α-Peptide/β-Peptoid Peptidomimetic Induces Stable Resistance
Hein-Kristensen, L., Franzyk, Henrik, Holch, A. & Gram, L., 2013, In: PLOS ONE. 8, 9, p. e73620Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains
Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In: B M C Microbiology. 11, 1, p. 144Research output: Contribution to journal › Journal article › Research › peer-review
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Linking activity and mode of action to length in a novel peptidomimetics library
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2010.Research output: Contribution to conference › Poster › Research
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Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
Hellewell, L., Gilani, N. M., Stanton, C. J., Pelligand, L., Franzyk, Henrik, Guardabassi, Luca & Good, L., 2022, In: Future Medicinal Chemistry. 14, 24, p. 1899–1921Research output: Contribution to journal › Review › Research › peer-review
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Peptidomimetics as novel formyl peptide receptor 2 (FPR2) modulators in human and mouse neutrophils
Holdfeldt, A., Dahlgren, C., Forsman, H., Skovbakke, S. L. & Franzyk, Henrik, 2016.Research output: Contribution to conference › Poster › Research
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Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function
Holdfeldt, A., Skovbakke, S. L., Gabl, M., Nielsen, C., Dahlgren, C., Franzyk, Henrik & Forsman, H., 28 Mar 2019, In: ACS Omega. 4, 3, p. 5968-5982 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil NADPH-oxidase
Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 291, 38, p. 19888-19899 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase
Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo
Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, Henrik, Lepenies, B., Christensen, D., Foged, Camilla & Lang, R., Aug 2016, In: Innate Immunity. 22, 6, p. 405-418 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of a proteolytically stable multifunctional host defense peptidomimetic
Jahnsen, R. D., Haney, E. F., Franzyk, Henrik & Hancock, R. E. W., 10 Oct 2013, In: Chemistry & Biology. 20, 10, p. 1286-1295 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli
Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones
Jahnsen, R. D., Frimodt-Møller, N. & Franzyk, Henrik, 2012, In: Journal of Medicinal Chemistry. 55, 16, p. 7253-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria
Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial Peptidomimetics
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2013.Research output: Contribution to conference › Poster › Research
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Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.Research output: Contribution to conference › Poster › Research
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Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48Research output: Contribution to journal › Journal article › Research › peer-review
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Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts
Jaroszewski, J. W., Olafsdottir, E. S., Wellendorph, Petrine, Christensen, J. L., Franzyk, Henrik, Somanadhan, B., Budnik, B. A., Jørgensen, L. B. & Clausen, V., 2002, In: Phytochemistry. 59, 5, p. 501-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Naravelia zeyanica: occurrence of primary benzamides in flowering plants
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H. & Franzyk, Henrik, 2005, In: Natural Product Research. 19, 3, p. 291-294Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: "Naravelia zeylanica: Occurrence of primary benzamides in flowering plants" (Natural Product Research vol. 19 (3) (291-294))
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H., Franzyk, Henrik & Somanadhan, B., 1 Jun 2005, In: Natural Product Research. 19, 4, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article › Communication
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Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation
Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL
Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position
Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.Research output: Contribution to journal › Journal article › Research › peer-review
Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers
Jensen, S. R., Franzyk, Henrik & Wallander, E., 2002, In: Phytochemistry. 60, 3, p. 213-31 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.
Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues
Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake
Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175Research output: Contribution to journal › Journal article › Research › peer-review
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Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group
Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109Research output: Contribution to journal › Conference abstract in journal › Research
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Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids
Jørgensen, Johan Storm, Harifi Mood, Elnaz, Knap, A. S. H., Nielsen, S. E., Nielsen, Peter E., Żabicka, D., Matias, C., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1370–1383Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism
Jørgensen, M., Olsen, Christian Adam, Mellor, I. R., Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2005, In: Journal of Medicinal Chemistry. 48, 1, p. 56-70 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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On-resin Carboxy Group Activation of ω-Amino Acids in Solid-Phase Synthesis of Philanthotoxin Analogues
Jørgensen, M. R., Jaroszewski, J. W., Witt, M. & Franzyk, Henrik, 2005, In: Synthesis. p. 2687-2694 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solution and Solid-Phase Synthesis of Philanthotoxin Analogues
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2002.Research output: Contribution to conference › Poster › Research
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Solid-phase Synthesis of Philanthotoxin Analogues with Modified and Elongated Polyamine Chains
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003.Research output: Contribution to conference › Poster › Research
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Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition
Kachel, H. S., Patel, R. N., Franzyk, Henrik & Mellor, I. R., 30 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 38116.Research output: Contribution to journal › Journal article › Research › peer-review
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Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency
Kachel, H. S., Franzyk, Henrik & Mellor, I. R., 11 Jul 2019, In: Journal of Medicinal Chemistry. 62, 13, p. 6214-6222Research output: Contribution to journal › Journal article › Research › peer-review
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Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins
Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.Research output: Contribution to journal › Journal article › Research
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Does the molecular structure of mono and diester analogues of trehalose-6,6’-dibehenate (TDB) influence the biophysical chracteristics and receptor interaction with Mincle ?
Kallerup, R. S., Martin-Bertelsen, Birte, Franzyk, Henrik, Korsholm, K. S., Huber, A., Lang, R. & Foged, Camilla, 2014. 1 p.Research output: Contribution to conference › Poster › Research
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Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes
Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA
Kallerup, R. S., Franzyk, Henrik, Schiøth, M. L., Justesen, S., Martin-Bertelsen, Birte, Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, Anan & Foged, Camilla, 12 May 2017, In: Molecular Pharmaceutics. 14, 7, p. 2294-2306 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of synthesis and antibacterial activity of a- and ß-peptoids
Knapp, K. M., Franzyk, Henrik & Jahnsen, R., 2010. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation
Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation
Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid Glycoside Biosynthesis in Penstemon Secundiflorus. Another H-5,H-9 Trans-Iridoid Glycoside
Krull, R. E., Stermitz, F. R., Franzyk, Henrik & Jensen, S. R., 1998, In: Phytochemistry. 49, p. 1605-1608 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii
Larsen, C. E., Larsen, C. J., Franzyk, Henrik & Regenberg, Birgitte, 2015, In: F E M S Yeast Research. 15, 3, 8 p., fov011.Research output: Contribution to journal › Journal article › Research › peer-review
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UV-guided Isolation of Verrucine A and B, novel Quinazolines from Penicillium verrucosum Structurally Related to Anacine from P. aurantiogriseum
Larsen, T. O., Franzyk, Henrik & Jensen, S. R., 1999, In: Journal of Natural Products. 62, 11, p. 1578-1580 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.Research output: Contribution to journal › Journal article › Research › peer-review
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High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum effect of antimicrobial peptides
Loffredo, M. R., Savini, F., Bobone, S., Casciaro, B., Franzyk, Henrik, Mangoni, M. L. & Stella, L., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 21, 10 p., e2014364118.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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