Henrik Franzyk

Henrik Franzyk

Associate Professor

Member of:

    ORCID: 0000-0002-2822-1927

    Publication year:
    All
    101 - 200 out of 274Page size: 100
    1. 2011
    2. Published

      Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

      Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In: B M C Microbiology. 11, 1, p. 144

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2012
    4. Published

      Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones

      Jahnsen, R. D., Frimodt-Møller, N. & Franzyk, Henrik, 2012, In: Journal of Medicinal Chemistry. 55, 16, p. 7253-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Antimicrobial peptides as novel delivery vehicles for genetic antibiotics

      Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012, In: Journal of Peptide Science. 18, Suppl. 1, p. S116-S117

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    6. Published

      Antimicrobial peptides as novel delivery vehicles for genetic antibiotics

      Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012. 2 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    7. Published

      Antimikrobielle peptider: et nyt våben mod multiresistente bakterier

      Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11

      Research output: Contribution to journal › Journal article › Communication

    8. Published

      Escherichia coli with resistance to α-peptide/β-peptoid peptidomimetics: Mutation of a gene related to structural changes of cell wall peptidoglycan

      Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2012.

      Research output: Contribution to conference › Poster › Research

    9. Published

      Håb om at ramme latente bakterier i deres skjul

      Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14

      Research output: Contribution to journal › Journal article › Research

    10. Published

      Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study

      Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.

      Research output: Contribution to conference › Poster › Research

    11. Published

      Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake

      Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues

      Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Solid-phase route to Fmoc-protected cationic amino acid building blocks

      Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues.

      Bahnsen, J. S., Franzyk, Henrik & Nielsen, Hanne Mørck, 2012.

      Research output: Contribution to conference › Poster › Research

    15. 2013
    16. Published

      Adaptive Evolution of Escherichia coli to an α-Peptide/β-Peptoid Peptidomimetic Induces Stable Resistance

      Hein-Kristensen, L., Franzyk, Henrik, Holch, A. & Gram, L., 2013, In: PLOS ONE. 8, 9, p. e73620

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Antimicrobial Peptidomimetics

      Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2013.

      Research output: Contribution to conference › Poster › Research

    18. Published

      Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

      Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013, In: B B A - Biomembranes. 1828, 2, p. 223-232 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Cell-penetrating Peptides Targeting Intracellular Infections

      Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    20. Published

      High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis

      Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line

      Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    22. Published

      Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides

      Steffensen, S. L., Møller, E. H., Franzyk, Henrik, Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    23. Published

      The supramolecular structure is decisive for the immunostimulatory properties of synthetic analogues of a mycobacterial lipid in vitro

      Martin-Bertelsen, Birte, Korsholm, K. S., Rose, F., Nordly, P. J., Franzyk, Henrik, Andersen, P., Agger, E. M., Christensen, D., Yaghmur, Anan & Foged, Camilla, 2013, In: R S C Advances. 3, 43, p. 20673-20683

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma

      Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 27 Aug 2013, In: Research in Microbiology. 164, 9, p. 933-940 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Characterization of a proteolytically stable multifunctional host defense peptidomimetic

      Jahnsen, R. D., Haney, E. F., Franzyk, Henrik & Hancock, R. E. W., 10 Oct 2013, In: Chemistry & Biology. 20, 10, p. 1286-1295 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2014
    27. Published

      Does the molecular structure of mono and diester analogues of trehalose-6,6’-dibehenate (TDB) influence the biophysical chracteristics and receptor interaction with Mincle ?

      Kallerup, R. S., Martin-Bertelsen, Birte, Franzyk, Henrik, Korsholm, K. S., Huber, A., Lang, R. & Foged, Camilla, 2014. 1 p.

      Research output: Contribution to conference › Poster › Research

    28. Published

      Human plasma potentiates antibacterial effect of peptidomimetics against Gram-negative and Gram-positive pathogenic bacteria

      Citterio, L., A, K., K, H., Franzyk, Henrik & Gram, L., 2014.

      Research output: Contribution to conference › Poster › Research

    29. Published

      Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics

      Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    30. Published

      Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics

      Vinther, J. M., Garrigues, C., Nyberg, N., Jäger, A., Franzyk, Henrik & Stærk, Dan, 2014.

      Research output: Contribution to conference › Poster › Research

    31. Published

      Silicone embedded nanogels for prolonged resistance against biofilm formation

      Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    32. Published

      The palmitoylated α-peptide/β-peptoid hybrid Pam-(Lys-βNSpe)6-NH2 is a novel host defense peptidomimetic with potent anti-inflammatory activity

      Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2014.

      Research output: Contribution to conference › Poster › Research

    33. Published

      The supramolecular structure is decisive for the immunoactivity of a mycobacterial lipid in vitro.

      Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2014. 1 p.

      Research output: Contribution to conference › Poster › Research

    34. Published

      Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins

      Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.

      Research output: Contribution to journal › Journal article › Research

    35. Published

      Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

      Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Quantification of pharmaceutical peptides using selenium as an elemental detection label

      Møller, L. H., Gabel-Jensen, C., Franzyk, Henrik, Bahnsen, J. S., Stürup, Stefan & Gammelgaard, Bente, 16 Jul 2014, In: Metallomics : integrated biometal science. 6, p. 1639-1647 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition

      Franzyk, Henrik, Grzeskowiak, J. W., Tikhonov, D. B., Jaroszewski, J. W. & Mellor, I. R., Aug 2014, In: ChemMedChem. 9, 8, p. 1725-31 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL

      Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. 2015
    40. Published

      A palmitoylated α-peptide/β-peptoid host defense peptide mimetic with potent anti-inflammatory activity

      Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research › peer-review

    41. Published

      Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii

      Larsen, C. E., Larsen, C. J., Franzyk, Henrik & Regenberg, Birgitte, 2015, In: F E M S Yeast Research. 15, 3, 8 p., fov011.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Biophysical and nanostructural properties of trehalose 6-mono and 6,6’-diesters

      Madsen, C. M., Martin-Bertelsen, Birte, Kallerup, R. S., Rose, F., Christensen, D., Yaghmur, Anan, Franzyk, Henrik & Foged, Camilla, 2015. 1 p.

      Research output: Contribution to conference › Poster › Research

    43. Published

      Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections

      Bahnsen, J. S., Franzyk, Henrik, Sayers, E. J., Jones, A. T. & Nielsen, Hanne Mørck, 2015, In: Pharmaceutical Research. 32, 5, p. 1546-56 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

      Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Intact penetratin metabolite permeates across Caco-2 monolayers

      Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2015.

      Research output: Contribution to conference › Poster › Research

    46. Published

      Jagten på kongens efterfølger

      Franzyk, Henrik, Björkling, Fredrik, Nielsen, J. & Nielsen, Peter E., 2015, In: Lægemiddelforskning. 2015, p. 24-27 4 p.

      Research output: Contribution to journal › Journal article › Communication

    47. Published

      Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity

      Skovbakke, S. L., Larsen, C. J., Heegaard, P. M. H., Moesby, L. & Franzyk, Henrik, 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 801-813 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

      Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research

    50. Published

      Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

      Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

      Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      The Proteolytically Stable Peptidomimetic Pam-(Lys-βNSpe)6-NH2 Selectively Inhibits Human Neutrophil Activation via Formyl Peptide Receptor 2

      Skovbakke, S. L., Heegaard, P. M. H., Larsen, C. J., Franzyk, Henrik, Forsman, H. & Dahlgren, C., 2015, In: Biochemical Pharmacology. 93, 2, p. 182-195 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria

      Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

      Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation

      Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

      Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 2016
    58. Published

      An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action

      Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Antibacterial Peptide Nucleic Acid-Antimicrobial Peptide (PNA-AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

      Hansen, A. M., Bonke, G., Larsen, C. J., Yavari, Niloofar, Nielsen, Peter E. & Franzyk, Henrik, 2016, In: Bioconjugate Chemistry. 27, 4, p. 863-867 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Breaching bacterial barricades: A high-throughput approach to identify compounds targeting envelope integrity

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    61. Published

      Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

      Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.

      Research output: Contribution to conference › Poster › Research

    62. Published

      Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

      Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy

      Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2016, In: Molecular Pharmaceutics. 13, 8, p. 2771-2781 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Peptidomimetics as novel formyl peptide receptor 2 (FPR2) modulators in human and mouse neutrophils

      Holdfeldt, A., Dahlgren, C., Forsman, H., Skovbakke, S. L. & Franzyk, Henrik, 2016.

      Research output: Contribution to conference › Poster › Research

    65. Published

      Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    66. Published

      Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

      Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions

      Baldry, M., Kitir, B., Frøkiær, Hanne, Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, Henrik, Olsen, Christian Adam, Wells, J. M. & Ingmer, Hanne, 2016, In: P L o S One. 11, 1, 17 p., e0145618.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase

      Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil NADPH-oxidase

      Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 291, 38, p. 19888-19899 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs, or antibiotics against human pathogenic bacteria

      Citterio, L., Franzyk, Henrik, Palarasah, Y., Andersen, T. E., Mateiu, R. V. & Gram, L., Feb 2016, In: Research in Microbiology. 167, 2, p. 72-82 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

      Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo

      Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, Henrik, Lepenies, B., Christensen, D., Foged, Camilla & Lang, R., Aug 2016, In: Innate Immunity. 22, 6, p. 405-418 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Noter til BIOPHARMACEUTICALS: BIOORGANISK KEMI

      Franzyk, Henrik & Nielsen, Peter E., 15 Aug 2016, Dept. Drug Design and Pharmacology. 159 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    74. Published

      ØVELSESVEJLEDNING TIL: Øvelsesdelen af Biopharmaceuticals: Bioorganisk Kemi

      Franzyk, Henrik, 15 Aug 2016, Dept. Drug Design and Pharmacology. 60 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    75. Published

      The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils

      Skovbakke, S. L., Winther, M., Gabl, M., Holdfeldt, A., Linden, S., Wang, J. M., Dahlgren, C., Franzyk, Henrik & Forsman, H., 8 Sep 2016, In: Biochemical Pharmacology. 119, p. 56-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      A high-throughput approach to identify compounds that impair envelope integrity in Escherichia coli

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, Oct 2016, In: Antimicrobial Agents and Chemotherapy. 60, 10, p. 5995-6002 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers

      Martin-Bertelsen, Birte, Yaghmur, Anan, Franzyk, Henrik, Justesen, S., Kirkensgaard, Jacob Judas Kain & Foged, Camilla, 7 Nov 2016, In: Langmuir. 32, 48, p. 12693–12701 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

      Kachel, H. S., Patel, R. N., Franzyk, Henrik & Mellor, I. R., 30 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 38116.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. 2017
    80. Published

      An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens

      Baker, K. R., Jana, B., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    81. Published

      Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization

      Skovbakke, S. L. & Franzyk, Henrik, 2017, Methods Molecular Biology: Antimicrobial Peptides. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 369-386 18 p. (Methods in Molecular Biology, Vol. 1548).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    82. Published

      Antisense PNA antibiotics against multiresistant Gram-negative bacteria

      Nielsen, Peter E., Björkling, Fredrik & Franzyk, Henrik, 2017, In: International Journal of Molecular Medicine. 40, Suppl. 1, p. S22 1 p., Abstract 169.

      Research output: Contribution to journal › Conference abstract in journal › Research

    83. Published

      Biopolymer-based nanogels improve the safety profile and antimicrobial activity of a lysine-based peptidomimetic.

      Franzyk, Henrik, 2017.

      Research output: Contribution to conference › Poster › Research › peer-review

    84. Published

      Combining elements from two antagonists of formyl peptide receptor 2 generates more potent peptidomimetic antagonists

      Skovbakke, S. L., Holdfeldt, A., Nielsen, C., Hansen, A. M., Perez-Gassol, I., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2017, In: Journal of Medicinal Chemistry. 60, 16, p. 6991-6997

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs

      Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Poster › Research

    86. Published

      Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability

      Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      On-resin N-formylation of peptides: a head-to-head comparison of reagents in solid-phase synthesis of ligands for formyl peptide receptors

      Christensen, S. B., Hansen, A. M. & Franzyk, Henrik, 2017, In: Journal of Peptide Science. 23, 5, p. 410-415 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA

      Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research

    90. Published

      Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    91. Published

      Synergistic peptidomimetic-antimicrobial combinations to combat multidrug-resistant Gram-negative bacterial infections

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    92. Published

      Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy

      Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Poster › Research

    93. Published

      Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA

      Kallerup, R. S., Franzyk, Henrik, Schiøth, M. L., Justesen, S., Martin-Bertelsen, Birte, Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, Anan & Foged, Camilla, 12 May 2017, In: Molecular Pharmaceutics. 14, 7, p. 2294-2306 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Advances in development of antimicrobial peptidomimetics as potential drugs

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.

      Research output: Contribution to journal › Review › Research › peer-review

    95. Published

      Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

      Foged, Camilla, Franzyk, Henrik, Zeng, X., Nielsen, Hanne Mørck & Thanki, K., 21 Sep 2017, IPC No. A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00, Patent No. WO2017158093-A1, 16 Mar 2017, Priority date 17 Mar 2016, Priority No. EP 2016-160931

      Research output: Patent

    96. Published

      Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

      Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. 2018
    98. Submitted

      Anchoring of hydrophilic coating polymers onto charged liposomes via attractive electrostatic interactions using charged tags to control the surface charge drainage properties and cellular targeting

      Andersen, P. L., Christensen, D., Franzyk, Henrik, Foged, Camilla & Schmidt, S. T., 2018, (Submitted)

      Research output: Patent

    99. Published

      Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin

      Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    100. Published

      Fastfase-syntese af Peptider - en visuel guide

      Franzyk, Henrik, 2018, 18 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    101. Published

      Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.

      Research output: Contribution to journal › Journal article › Research › peer-review

    102. Published

      Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction

      Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      Guide til Rapportskrivning i Kurset Biopharmaceuticals: Bioorganisk Kemi 2018

      Franzyk, Henrik, 2018, 17 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    104. Published

      High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans

      Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures

      McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists

      Hansen, A. M., Peng, P., Baldry, M., Perez-Gassol, I., Christensen, S. B., Vinther, J. M., Ingmer, Hanne & Franzyk, Henrik, 2018, In: European Journal of Medicinal Chemistry. 152, p. 370-376 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

      Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    108. Published

      Mini-manual: Søgninger i Reaxys

      Franzyk, Henrik, 2018, 4 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    Previous 1 2 3 Next

    ID: 1302063