Henrik Franzyk

Henrik Franzyk

Associate Professor

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    ORCID: 0000-0002-2822-1927

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    1. Recent techniques in Glycopeptide synthesis and biology: the glycopeptide templates

      Meldal, M., Franzyk, Henrik, Meinjohanns, E., Vargas-Berenguel, A., Frische, K., Christensen, M. K., Christensen, I. B., Jensen, K. J. & Bock, K., 1997, Innovations and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Kingswinford: Mayflower Scientific, p. 263-268 6 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    2. Published

      Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

      Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

      Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

      Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Rifampicin-loaded N-acetylcysteine-chitosan nanoparticles surface-grafted with a peptide exhibit potent activity against multidrug-resistant Mycobacterium tuberculosis

      Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 11 Jun 2023. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    6. Published

      Ring opening of a Resin-bound chiral aziridine with phenols

      Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Synfacts. 2010, 11, p. 1319 1 p.

      Research output: Contribution to journal › Journal article › Research

    7. Published

      Ring opening of a resin-bound chiral aziridine with phenol nucleophiles

      Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Journal of Organic Chemistry. 75, 15, p. 4983-4991

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    9. Published

      SYNTHESIS OF NOVEL HYDROXYMETHYL SUBSTITUTED ANALOGUES RELATED TO CARBOVIR AND NEPLANOCIN A

      Franzyk, Henrik, Jensen, S. R., Olsen, C. E. & Rasmussena, J. H., Apr 2002, In: Nucleosides, Nucleotides and Nucleic Acids.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Selected strategies to fight pathogenic bacteria

      Plotniece, A., Sobolev, A., Supuran, C. T., Carta, F., Björkling, Fredrik, Franzyk, Henrik, Yli-Kauhaluoma, J., Augustyns, K., Cos, P., De Vooght, L., Govaerts, M., Aizawa, J., Tammela, P. & Žalubovskis, R., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 27 p., 2155816.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

      Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma

      Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 27 Aug 2013, In: Research in Microbiology. 164, 9, p. 933-940 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

      Olsen, Christian Adam, Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Organic Letters. 7, 9, p. 1703-6 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Silicone embedded nanogels for prolonged resistance against biofilm formation

      Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    15. Published

      Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems

      Lokras, Abhijeet, Chakravarty, A., Rades, Thomas, Christensen, D., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

      Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Solid-phase Synthesis of Philanthotoxin Analogues with Modified and Elongated Polyamine Chains

      Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003.

      Research output: Contribution to conference › Poster › Research

    18. Published

      Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers

      Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Solid-phase polyamine synthesis using piperazine and piperidine building blocks

      Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: Organic Letters. 5, 22, p. 4183-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Solid-phase route to Fmoc-protected cationic amino acid building blocks

      Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker

      Olsen, Christian Adam, Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Tetrahedron Letters. 48, 3, p. 405-408

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers

      Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Journal of Organic Chemistry. 69, 18, p. 6149-52 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Solution and Solid-Phase Synthesis of Philanthotoxin Analogues

      Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2002.

      Research output: Contribution to conference › Poster › Research

    24. Published

      Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

      Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin

      Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, Henrik & Nielsen, Hanne Mørck, 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Stereoselective Hydrogenation and Ozonolysis of Iridoids. Conversion into Carbocyclic Nucleoside Analogues

      Franzyk, Henrik & Stermitz, F. R., 1999, In: Journal of Natural Products. 62, p. 1646-1654 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation.

      Viklund, M., Fredriksson, J., Holdfeldt, A., Lind, S., Franzyk, Henrik, Dahlgren, C., Sundqvist, M. & Forsman, H., 2022, In: Journal of Immunology. 208, 7, p. 1632-1641

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research

    29. Published

      Structure-Activity Study of alpha-Peptoid/alpha-Peptide Peptidomimetics: Influence of Hydrophobicity on Antimicrobial Activity and Cytotoxicity

      Frederiksen, N., Bjorkling, F., Nielsen, P. & Franzyk, Henrik, Sep 2018, In: Journal of Peptide Science. 24, s2, p. S120-S120

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    30. Published

      Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function

      Holdfeldt, A., Skovbakke, S. L., Gabl, M., Nielsen, C., Dahlgren, C., Franzyk, Henrik & Forsman, H., 28 Mar 2019, In: ACS Omega. 4, 3, p. 5968-5982 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    32. Published

      Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues

      Shaikh, Ashif Yasin, Björkling, Fredrik, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Kreicberga, A. & Franzyk, Henrik, 2023, In: Bioorganic Chemistry. 141, 11 p., 106876.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)

      Couturier, C., Ronzon, Q., Lattanzi, G., Lingard, I., Coyne, S., Cazals, V., Dubarry, N., Yvon, S., Leroi-Geissler, C., Gracia, O. R., Teague, J., Sordello, S., Corbett, D., Bauch, C., Monlong, C., Payne, L., Taillier, T., Fuchs, H., Broenstrup, M., Harrison, P. H. & 10 others, Moynié, L., Lakshminarayanan, A., Gianga, T. M., Hussain, R., Naismith, J. H., Mourez, M., Bacqué, E., Björkling, Fredrik, Sabuco, J. F. & Franzyk, Henrik, 2024, In: European Journal of Medicinal Chemistry. 265, 20 p., 116097.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Studies on acid stability and solid-phase block synthesis of peptide-peptoid hybrids: ligands for formyl peptide receptors

      Hansen, A. M., Skovbakke, S. L., Christensen, S. B., Perez-Gassol, I. & Franzyk, Henrik, 2019, In: Amino Acids. 51, p. 205-218

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery

      Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23-24, p. 1109 1 p., A81.

      Research output: Contribution to journal › Conference abstract in journal › Research

    36. Published

      Studies towards improved stability and permeability of a cell-penetrating peptide

      Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Journal of Peptide Science. 16, p. 148 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research

    37. Published

      Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics

      Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins

      Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.

      Research output: Contribution to journal › Journal article › Research

    39. Published

      Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

      Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

      Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Synergistic peptidomimetic-antimicrobial combinations to combat multidrug-resistant Gram-negative bacterial infections

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    42. Published

      Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy

      Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Poster › Research

    43. Synthesis of Antirrhinolide, a New Lactone from Antirrhinum majus

      Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., 1998, In: European Journal of Organic Chemistry. p. 1665-1667 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Synthesis of Antirrhinolide, a New Lactone fromAntirrhinum Majus

      Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., Aug 1998, In: European Journal of Organic Chemistry.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Synthesis of Carbocyclic Homo-N-nucleosides from Iridoids

      Franzyk, Henrik, Rasmussen, J. H., Mazzei, R. A. & Jensen, S. R., 1998, In: European Journal of Organic Chemistry. p. 2931-2935 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Synthesis of Monoterpene Piperidines from the Iridoid Glucoside Antirrhinoside

      Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., 1997, In: Journal of Natural Products. 60, p. 1012-1016 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Synthesis of aliphatic O-dimannosyl amino acid building blocks for solid-phase assembly of glycopeptide libraries

      Franzyk, Henrik, Meldal, M., Paulsen, H. & Bock, K., 1995, In: Journal of the Chemical Society, Perkin Transactions 1. 36, 9, p. 2883-2898 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A

      Franzyk, Henrik, Jensen, S. R., Olsen, C. E. & Rasmussen, J. H., 2002, In: Nucleosides, Nucleotides and Nucleic Acids. 21, 1, p. 23-43 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Synthetic aspects of iridoid chemistry

      Franzyk, Henrik, 2000, In: Fortschritte der Chemie Organischer Naturstoffe. 79, p. 1-114 114 p.

      Research output: Contribution to journal › Review › Research

    50. Published

      Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

      Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

      Research output: Contribution to journal › Journal article › Research › peer-review

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