Henrik Franzyk

Henrik Franzyk

Associate Professor

Member of:

    ORCID: 0000-0002-2822-1927

    Publication year:
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    101 - 150 out of 274Page size: 50
    1. 2017
    2. Published

      Synergistic peptidomimetic-antimicrobial combinations to combat multidrug-resistant Gram-negative bacterial infections

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    3. Published

      Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy

      Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

      Research output: Contribution to conference › Poster › Research

    4. 2016
    5. Published

      Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

      Kachel, H. S., Patel, R. N., Franzyk, Henrik & Mellor, I. R., 30 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 38116.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers

      Martin-Bertelsen, Birte, Yaghmur, Anan, Franzyk, Henrik, Justesen, S., Kirkensgaard, Jacob Judas Kain & Foged, Camilla, 7 Nov 2016, In: Langmuir. 32, 48, p. 12693–12701 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A high-throughput approach to identify compounds that impair envelope integrity in Escherichia coli

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, Oct 2016, In: Antimicrobial Agents and Chemotherapy. 60, 10, p. 5995-6002 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils

      Skovbakke, S. L., Winther, M., Gabl, M., Holdfeldt, A., Linden, S., Wang, J. M., Dahlgren, C., Franzyk, Henrik & Forsman, H., 8 Sep 2016, In: Biochemical Pharmacology. 119, p. 56-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Noter til BIOPHARMACEUTICALS: BIOORGANISK KEMI

      Franzyk, Henrik & Nielsen, Peter E., 15 Aug 2016, Dept. Drug Design and Pharmacology. 159 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    10. Published

      ØVELSESVEJLEDNING TIL: Øvelsesdelen af Biopharmaceuticals: Bioorganisk Kemi

      Franzyk, Henrik, 15 Aug 2016, Dept. Drug Design and Pharmacology. 60 p.

      Research output: Book/Report › Compendium/lecture notes › Education

    11. Published

      Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages invitro and adjuvant activity invivo

      Huber, A., Kallerup, R. S., Korsholm, K. S., Franzyk, Henrik, Lepenies, B., Christensen, D., Foged, Camilla & Lang, R., Aug 2016, In: Innate Immunity. 22, 6, p. 405-418 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

      Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs, or antibiotics against human pathogenic bacteria

      Citterio, L., Franzyk, Henrik, Palarasah, Y., Andersen, T. E., Mateiu, R. V. & Gram, L., Feb 2016, In: Research in Microbiology. 167, 2, p. 72-82 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action

      Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Antibacterial Peptide Nucleic Acid-Antimicrobial Peptide (PNA-AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

      Hansen, A. M., Bonke, G., Larsen, C. J., Yavari, Niloofar, Nielsen, Peter E. & Franzyk, Henrik, 2016, In: Bioconjugate Chemistry. 27, 4, p. 863-867 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Breaching bacterial barricades: A high-throughput approach to identify compounds targeting envelope integrity

      Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    17. Published

      Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

      Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.

      Research output: Contribution to conference › Poster › Research

    18. Published

      Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

      Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy

      Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2016, In: Molecular Pharmaceutics. 13, 8, p. 2771-2781 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Peptidomimetics as novel formyl peptide receptor 2 (FPR2) modulators in human and mouse neutrophils

      Holdfeldt, A., Dahlgren, C., Forsman, H., Skovbakke, S. L. & Franzyk, Henrik, 2016.

      Research output: Contribution to conference › Poster › Research

    21. Published

      Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    22. Published

      Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

      Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions

      Baldry, M., Kitir, B., Frøkiær, Hanne, Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, Henrik, Olsen, Christian Adam, Wells, J. M. & Ingmer, Hanne, 2016, In: P L o S One. 11, 1, 17 p., e0145618.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase

      Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil NADPH-oxidase

      Holdfeldt, A., Skovbakke, S. L., Winther, M., Gabl, M., Nielsen, C., Perez-Gassol, I., Larsen, C. J., Wang, J. M., Karlsson, A., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2016, In: Journal of Biological Chemistry. 291, 38, p. 19888-19899 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2015
    27. Published

      Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

      Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation

      Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

      Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria

      Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      A palmitoylated α-peptide/β-peptoid host defense peptide mimetic with potent anti-inflammatory activity

      Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research › peer-review

    32. Published

      Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii

      Larsen, C. E., Larsen, C. J., Franzyk, Henrik & Regenberg, Birgitte, 2015, In: F E M S Yeast Research. 15, 3, 8 p., fov011.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Biophysical and nanostructural properties of trehalose 6-mono and 6,6’-diesters

      Madsen, C. M., Martin-Bertelsen, Birte, Kallerup, R. S., Rose, F., Christensen, D., Yaghmur, Anan, Franzyk, Henrik & Foged, Camilla, 2015. 1 p.

      Research output: Contribution to conference › Poster › Research

    34. Published

      Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections

      Bahnsen, J. S., Franzyk, Henrik, Sayers, E. J., Jones, A. T. & Nielsen, Hanne Mørck, 2015, In: Pharmaceutical Research. 32, 5, p. 1546-56 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

      Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Intact penetratin metabolite permeates across Caco-2 monolayers

      Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2015.

      Research output: Contribution to conference › Poster › Research

    37. Published

      Jagten på kongens efterfølger

      Franzyk, Henrik, Björkling, Fredrik, Nielsen, J. & Nielsen, Peter E., 2015, In: Lægemiddelforskning. 2015, p. 24-27 4 p.

      Research output: Contribution to journal › Journal article › Communication

    38. Published

      Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity

      Skovbakke, S. L., Larsen, C. J., Heegaard, P. M. H., Moesby, L. & Franzyk, Henrik, 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 801-813 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

      Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research

    41. Published

      Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

      Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

      Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      The Proteolytically Stable Peptidomimetic Pam-(Lys-βNSpe)6-NH2 Selectively Inhibits Human Neutrophil Activation via Formyl Peptide Receptor 2

      Skovbakke, S. L., Heegaard, P. M. H., Larsen, C. J., Franzyk, Henrik, Forsman, H. & Dahlgren, C., 2015, In: Biochemical Pharmacology. 93, 2, p. 182-195 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2014
    45. Published

      Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL

      Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, Henrik & Mirza, Osman Asghar, 24 Sep 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition

      Franzyk, Henrik, Grzeskowiak, J. W., Tikhonov, D. B., Jaroszewski, J. W. & Mellor, I. R., Aug 2014, In: ChemMedChem. 9, 8, p. 1725-31 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Quantification of pharmaceutical peptides using selenium as an elemental detection label

      Møller, L. H., Gabel-Jensen, C., Franzyk, Henrik, Bahnsen, J. S., Stürup, Stefan & Gammelgaard, Bente, 16 Jul 2014, In: Metallomics : integrated biometal science. 6, p. 1639-1647 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

      Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins

      Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.

      Research output: Contribution to journal › Journal article › Research

    50. Published

      Does the molecular structure of mono and diester analogues of trehalose-6,6’-dibehenate (TDB) influence the biophysical chracteristics and receptor interaction with Mincle ?

      Kallerup, R. S., Martin-Bertelsen, Birte, Franzyk, Henrik, Korsholm, K. S., Huber, A., Lang, R. & Foged, Camilla, 2014. 1 p.

      Research output: Contribution to conference › Poster › Research

    51. Published

      Human plasma potentiates antibacterial effect of peptidomimetics against Gram-negative and Gram-positive pathogenic bacteria

      Citterio, L., A, K., K, H., Franzyk, Henrik & Gram, L., 2014.

      Research output: Contribution to conference › Poster › Research

    52. Published

      Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics

      Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    53. Published

      Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics

      Vinther, J. M., Garrigues, C., Nyberg, N., Jäger, A., Franzyk, Henrik & Stærk, Dan, 2014.

      Research output: Contribution to conference › Poster › Research

    54. Published

      Silicone embedded nanogels for prolonged resistance against biofilm formation

      Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

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