Henrik Franzyk
Associate Professor
- 2014
- Published
The palmitoylated α-peptide/β-peptoid hybrid Pam-(Lys-βNSpe)6-NH2 is a novel host defense peptidomimetic with potent anti-inflammatory activity
Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2014.Research output: Contribution to conference › Poster › Research
- Published
- 2013
- Published
Characterization of a proteolytically stable multifunctional host defense peptidomimetic
Jahnsen, R. D., Haney, E. F., Franzyk, Henrik & Hancock, R. E. W., 10 Oct 2013, In: Chemistry & Biology. 20, 10, p. 1286-1295 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma
Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 27 Aug 2013, In: Research in Microbiology. 164, 9, p. 933-940 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptive Evolution of Escherichia coli to an α-Peptide/β-Peptoid Peptidomimetic Induces Stable Resistance
Hein-Kristensen, L., Franzyk, Henrik, Holch, A. & Gram, L., 2013, In: PLOS ONE. 8, 9, p. e73620Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial Peptidomimetics
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2013.Research output: Contribution to conference › Poster › Research
- Published
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013, In: B B A - Biomembranes. 1828, 2, p. 223-232 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-penetrating Peptides Targeting Intracellular Infections
Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line
Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides
Steffensen, S. L., Møller, E. H., Franzyk, Henrik, Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
The supramolecular structure is decisive for the immunostimulatory properties of synthetic analogues of a mycobacterial lipid in vitro
Martin-Bertelsen, Birte, Korsholm, K. S., Rose, F., Nordly, P. J., Franzyk, Henrik, Andersen, P., Agger, E. M., Christensen, D., Yaghmur, Anan & Foged, Camilla, 2013, In: R S C Advances. 3, 43, p. 20673-20683Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones
Jahnsen, R. D., Frimodt-Møller, N. & Franzyk, Henrik, 2012, In: Journal of Medicinal Chemistry. 55, 16, p. 7253-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial peptides as novel delivery vehicles for genetic antibiotics
Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012, In: Journal of Peptide Science. 18, Suppl. 1, p. S116-S117Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Antimicrobial peptides as novel delivery vehicles for genetic antibiotics
Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Antimikrobielle peptider: et nyt våben mod multiresistente bakterier
Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11Research output: Contribution to journal › Journal article › Communication
- Published
Escherichia coli with resistance to α-peptide/β-peptoid peptidomimetics: Mutation of a gene related to structural changes of cell wall peptidoglycan
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2012.Research output: Contribution to conference › Poster › Research
- Published
Håb om at ramme latente bakterier i deres skjul
Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14Research output: Contribution to journal › Journal article › Research
- Published
Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.Research output: Contribution to conference › Poster › Research
- Published
Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake
Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues
Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase route to Fmoc-protected cationic amino acid building blocks
Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues.
Bahnsen, J. S., Franzyk, Henrik & Nielsen, Hanne Mørck, 2012.Research output: Contribution to conference › Poster › Research
- 2011
- Published
Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains
Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In: B M C Microbiology. 11, 1, p. 144Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
A synthetic mycobacterial monomycoloyl glycerol analogue stabilizes DDA liposomes
Nordly, P. J., Pedersen, E. A., Khiljii, T. S., Agger, E. M., Jørgensen, Lene, Nielsen, Hanne Mørck, Korsholm, K. S., Franzyk, Henrik & Foged, Camilla, 2010, In: CRS Newsletter. 27, 2, p. 12 14 p.Research output: Contribution to journal › Journal article › Research
- Published
Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists
Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In: Journal of Medicinal Chemistry. 53, 20, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of synthesis and antibacterial activity of a- and ß-peptoids
Knapp, K. M., Franzyk, Henrik & Jahnsen, R., 2010. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Linking activity and mode of action to length in a novel peptidomimetics library
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2010.Research output: Contribution to conference › Poster › Research
- Published
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers
Nielsen, Hanne Mørck, Jing, X., Simonsen, A., Kasimova, M. R., Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2010, In: Journal of Peptide Science. 16, s1, p. 151 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group
Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Ring opening of a Resin-bound chiral aziridine with phenols
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Synfacts. 2010, 11, p. 1319 1 p.Research output: Contribution to journal › Journal article › Research
- Published
Ring opening of a resin-bound chiral aziridine with phenol nucleophiles
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Journal of Organic Chemistry. 75, 15, p. 4983-4991Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23-24, p. 1109 1 p., A81.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Studies towards improved stability and permeability of a cell-penetrating peptide
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Journal of Peptide Science. 16, p. 148 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- 2009
- Published
Expedite Protocol for Construction of Chiral Regioselectively N-Protected Monosubstituted Piperazine, 1,4-Diazepane, and 1,4-Diazocane Building Blocks
Crestey, F., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 11 Jun 2009, In: Journal of Organic Chemistry. 74, 15, p. 5652-5655Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations
Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides
Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dimeric Building Blocks for Solid-Phase Synthesis of α-Peptide-β-Peptoid Chimeras
Seigan, G. B., Vedel, L., Matthias, W., Jaroszewski, J. W., Olsen, Christian Adam & Franzyk, Henrik, 2008, In: Synthesis. 2008, 15, p. 2381-2390 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient loading of primary alcohols onto a solid phase using a trityl bromide linker
Crestey, F., Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2008, In: Tetrahedron Letters. 49, 41, p. 5890-5893Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors
Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.Research output: Contribution to conference › Poster › Research
- Published
Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article › Communication
- Published
Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines
Franzyk, Henrik, Crestey, F., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan & Jaroszewski, J., 2008, In: Synfacts. 7, p. 769Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microwave-assisted ring-opening of activated aziridines with resin-bound amines
Crestey, F., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan, Jaroszewski, J. W. & Franzyk, Henrik, 2008, In: Journal of Organic Chemistry. 73, 9, p. 3566-3569 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers
Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras
Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aziridines in parallel- and solid-phase synthesis
Olsen, Christian Adam, Bonke, G., Vedel, L., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: European Journal of Organic Chemistry. 2007, 11, p. 1717-1724Research output: Contribution to journal › Review › Research › peer-review
ID: 1302063
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1999
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1599
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
Published -
1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published