Henrik Franzyk
Associate Professor
- Published
Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. p. 473-476 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Choice of Phosphane Reagent in Fukuyama-Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of Philanthotoxins
Olsen, Christian Adam, Jørgensen, M. R., Witt, M., Mellor, I. R., Usherwood, P. N. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: European Journal of Organic Chemistry. p. 3288-3299 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route
Ongun, Melike, Lokras, Abhijeet, Baghel, Saahil Sandeep, Shi, Zhenning, Schmidt, S. T., Franzyk, Henrik, Rades, Thomas, Sebastiani, Federica, Thakur, A. & Foged, Camilla, 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ring opening of a Resin-bound chiral aziridine with phenols
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Synfacts. 2010, 11, p. 1319 1 p.Research output: Contribution to journal › Journal article › Research
- Published
Ring opening of a resin-bound chiral aziridine with phenol nucleophiles
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Journal of Organic Chemistry. 75, 15, p. 4983-4991Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations
Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock
Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selected strategies to fight pathogenic bacteria
Plotniece, A., Sobolev, A., Supuran, C. T., Carta, F., Björkling, Fredrik, Franzyk, Henrik, Yli-Kauhaluoma, J., Augustyns, K., Cos, P., De Vooght, L., Govaerts, M., Aizawa, J., Tammela, P. & Žalubovskis, R., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 27 p., 2155816.Research output: Contribution to journal › Review › Research › peer-review
- Published
Antimicrobial peptides grafted onto the surface of N-acetylcysteine-chitosan nanoparticles can revitalize drugs against clinical isolates of Mycobacterium tuberculosis
Primo, L. M. D. G., Roque-Borda, C. A., Carnero Canales, C. S., Caruso, I. P., de Lourenço, I. O., Colturato, V. M. M., Sábio, R. M., de Melo, F. A., Vicente, E. F., Chorilli, M., da Silva Barud, H., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 2024, In: Carbohydrate Polymers. 323, 17 p., 121449.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein
Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, Thomas, Franzyk, Henrik, Pedersen, Anders Elm, Papadakis, C. M., Christensen, D., Winter, G., Foged, Camilla & Hubert, M., 10 Sep 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acetylcysteine-chitosan nanoparticles with the Ctx(Ile21)-Ha peptide grafted onto the surface can rescue the susceptibility of pre-extensively resistant Mycobacterium tuberculosis
Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 2 Oct 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
- Published
The effect of Cys15 and Cys21 replacement with Ala, Ser and Lys on the anti Mycobacterium tuberculosis activity of antimicrobial peptide B1CTcu5
Roque-Borda, C. A., Costa de Pontes, J. T., Domingos da Silva, L. H., Caroline dos Santos, I. C. D. S., Aparecida Resende, F., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 2023.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Rifampicin-loaded N-acetylcysteine-chitosan nanoparticles surface-grafted with a peptide exhibit potent activity against multidrug-resistant Mycobacterium tuberculosis
Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 11 Jun 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
Chemotaxonomy of Plantago. Iridoid glucosides and caffeoyl phenylethanoid glycosides
Rønsted, N., Gøbel, E., Franzyk, Henrik, Jensen, S. R. & Olsen, C. E., 2000, In: Phytochemistry. 55, 4, p. 337-48 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemotaxonomy and Evolution of Plantago L
Rønsted, Nina, Mølgaard, Per, Franzyk, Henrik, Jaroszewski, J. W. & Jensen, S. R., 2003, In: Plant Systematics and Evolution. 242, p. 63-82 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological response in E. coli to YdgR overexpression depends on whether the protein has an intact function
Sajid, Salvia, Salas, L. H., Rafiq, M., Lund, T., Jørgensen, M. G., Honoré, B., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, In: Biochemical and Biophysical Research Communications. 661, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
The Y-ome Conundrum: Insights into Uncharacterized Genes and Approaches for Functional Annotation
Sajid, Salvia, Mashkoor, M., Jørgensen, M. G., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, (Accepted/In press) In: Molecular and Cellular Biochemistry. 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Dimeric Building Blocks for Solid-Phase Synthesis of α-Peptide-β-Peptoid Chimeras
Seigan, G. B., Vedel, L., Matthias, W., Jaroszewski, J. W., Olsen, Christian Adam & Franzyk, Henrik, 2008, In: Synthesis. 2008, 15, p. 2381-2390 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial peptides as novel delivery vehicles for genetic antibiotics
Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012, In: Journal of Peptide Science. 18, Suppl. 1, p. S116-S117Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Antimicrobial peptides as novel delivery vehicles for genetic antibiotics
Seigan, G. B., Franzyk, Henrik & Nielsen, Peter E., 2012. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.
Shaikh, Ashif Yasin, Björkling, Fredrik, Nielsen, Peter E. & Franzyk, Henrik, 2021, In: European Journal of Organic Chemistry. 2021, 19, p. 2792-2801 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues
Shaikh, Ashif Yasin, Björkling, Fredrik, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Kreicberga, A. & Franzyk, Henrik, 2023, In: Bioorganic Chemistry. 141, 11 p., 106876.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis
Shaikh, Ashif Yasin, Hansen, A. M. & Franzyk, Henrik, 2020, Peptide Nucleic Acids: Methods and Protocols. P. E. N. (ed.). Humana Press, p. 1-16 16 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2105).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization
Skovbakke, S. L. & Franzyk, Henrik, 2017, Methods Molecular Biology: Antimicrobial Peptides. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 369-386 18 p. (Methods in Molecular Biology, Vol. 1548).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A palmitoylated α-peptide/β-peptoid host defense peptide mimetic with potent anti-inflammatory activity
Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2015.Research output: Contribution to conference › Poster › Research › peer-review
- Published
The palmitoylated α-peptide/β-peptoid hybrid Pam-(Lys-βNSpe)6-NH2 is a novel host defense peptidomimetic with potent anti-inflammatory activity
Skovbakke, S. L., Heegaard, P. M. H., Forsman, H., Dahlgren, C. & Franzyk, Henrik, 2014.Research output: Contribution to conference › Poster › Research
- Published
The Proteolytically Stable Peptidomimetic Pam-(Lys-βNSpe)6-NH2 Selectively Inhibits Human Neutrophil Activation via Formyl Peptide Receptor 2
Skovbakke, S. L., Heegaard, P. M. H., Larsen, C. J., Franzyk, Henrik, Forsman, H. & Dahlgren, C., 2015, In: Biochemical Pharmacology. 93, 2, p. 182-195 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils
Skovbakke, S. L., Winther, M., Gabl, M., Holdfeldt, A., Linden, S., Wang, J. M., Dahlgren, C., Franzyk, Henrik & Forsman, H., 8 Sep 2016, In: Biochemical Pharmacology. 119, p. 56-65 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity
Skovbakke, S. L., Larsen, C. J., Heegaard, P. M. H., Moesby, L. & Franzyk, Henrik, 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 801-813 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics
Skovbakke, S. L., Holdfeldt , A., Forsman, H., Bylund, J. & Franzyk, Henrik, 2018, In: Current Pharmaceutical Design. 24, 10, p. 1100-1120 21 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Combining elements from two antagonists of formyl peptide receptor 2 generates more potent peptidomimetic antagonists
Skovbakke, S. L., Holdfeldt, A., Nielsen, C., Hansen, A. M., Perez-Gassol, I., Dahlgren, C., Forsman, H. & Franzyk, Henrik, 2017, In: Journal of Medicinal Chemistry. 60, 16, p. 6991-6997Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides
Steffensen, S. L., Møller, E. H., Franzyk, Henrik, Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices
Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices
Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Silicone embedded nanogels for prolonged resistance against biofilm formation
Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy
Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Moderne naturstofkemi: effektiv analyse af naturens stofbiblioteker
Stærk, Dan, Lemmich, E., Franzyk, Henrik, Lemmich, J. & Jaroszewski, J. W., 2000, In: Lægemiddelforskning. p. 6-7Research output: Contribution to journal › Journal article › Communication
- Published
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
Sundqvist, M., Holdfeldt, A., Wright, S. C., Møller, T. C., Siaw, E., Jennbacken, K., Franzyk, Henrik, Bouvier, M., Dahlgren, C. & Forsman, H., 2020, In: B B A - Molecular Cell Research. 1867, 12, 13 p., 118849.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Sæbø, I. P., Bjørås, M., Franzyk, Henrik, Helgesen, E. & Booth, J. A., 2023, In: International Journal of Molecular Sciences. 24, 3, 20 p., 2914.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration
Tandrup Schmidt, S., Line Olsen, C., Franzyk, Henrik, Wørzner, K., Smith Korsholm, K., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 140, p. 29-39 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics
Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins
Thakur, A., Wadhwa, A., Lokras, Abhijeet, Amanda Oest Müllertz, O., Christensen, D., Franzyk, Henrik & Foged, Camilla, 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery
Thanki, K., Papai, S., Lokras, Abhijeet, Rose, F., Falkenberg, E., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 3, 37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- Published
Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.
Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.Research output: Contribution to conference › Poster › Research
- Published
Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies
Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, , 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras
Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
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2001
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
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1600
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
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1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published