Henrik Franzyk
Associate Professor
Recent techniques in Glycopeptide synthesis and biology: the glycopeptide templates
Meldal, M., Franzyk, Henrik, Meinjohanns, E., Vargas-Berenguel, A., Frische, K., Christensen, M. K., Christensen, I. B., Jensen, K. J. & Bock, K., 1997, Innovations and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Kingswinford: Mayflower Scientific, p. 263-268 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics
Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9Research output: Contribution to journal › Journal article › Research › peer-review
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Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock
Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.Research output: Contribution to journal › Journal article › Research › peer-review
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Rifampicin-loaded N-acetylcysteine-chitosan nanoparticles surface-grafted with a peptide exhibit potent activity against multidrug-resistant Mycobacterium tuberculosis
Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 11 Jun 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Ring opening of a Resin-bound chiral aziridine with phenols
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Synfacts. 2010, 11, p. 1319 1 p.Research output: Contribution to journal › Journal article › Research
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Ring opening of a resin-bound chiral aziridine with phenol nucleophiles
Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Journal of Organic Chemistry. 75, 15, p. 4983-4991Research output: Contribution to journal › Journal article › Research › peer-review
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SYNTHESIS OF NOVEL HYDROXYMETHYL SUBSTITUTED ANALOGUES RELATED TO CARBOVIR AND NEPLANOCIN A
Franzyk, Henrik, Jensen, S. R., Olsen, C. E. & Rasmussena, J. H., Apr 2002, In: Nucleosides, Nucleotides and Nucleic Acids.Research output: Contribution to journal › Journal article › Research › peer-review
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Selected strategies to fight pathogenic bacteria
Plotniece, A., Sobolev, A., Supuran, C. T., Carta, F., Björkling, Fredrik, Franzyk, Henrik, Yli-Kauhaluoma, J., Augustyns, K., Cos, P., De Vooght, L., Govaerts, M., Aizawa, J., Tammela, P. & Žalubovskis, R., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 27 p., 2155816.Research output: Contribution to journal › Review › Research › peer-review
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Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations
Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978Research output: Contribution to journal › Journal article › Research › peer-review
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Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma
Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 27 Aug 2013, In: Research in Microbiology. 164, 9, p. 933-940 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis
Olsen, Christian Adam, Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Organic Letters. 7, 9, p. 1703-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Silicone embedded nanogels for prolonged resistance against biofilm formation
Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
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Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems
Lokras, Abhijeet, Chakravarty, A., Rades, Thomas, Christensen, D., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.Research output: Contribution to journal › Journal article › Research › peer-review
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Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices
Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase Synthesis of Philanthotoxin Analogues with Modified and Elongated Polyamine Chains
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003.Research output: Contribution to conference › Poster › Research
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Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers
Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase polyamine synthesis using piperazine and piperidine building blocks
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: Organic Letters. 5, 22, p. 4183-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase route to Fmoc-protected cationic amino acid building blocks
Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker
Olsen, Christian Adam, Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Tetrahedron Letters. 48, 3, p. 405-408Research output: Contribution to journal › Journal article › Research › peer-review
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Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers
Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Journal of Organic Chemistry. 69, 18, p. 6149-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solution and Solid-Phase Synthesis of Philanthotoxin Analogues
Jørgensen, M. R., Jaroszewski, J. W. & Franzyk, Henrik, 2002.Research output: Contribution to conference › Poster › Research
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Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin
Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, Henrik & Nielsen, Hanne Mørck, 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.Research output: Contribution to journal › Journal article › Research › peer-review
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Stereoselective Hydrogenation and Ozonolysis of Iridoids. Conversion into Carbocyclic Nucleoside Analogues
Franzyk, Henrik & Stermitz, F. R., 1999, In: Journal of Natural Products. 62, p. 1646-1654 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation.
Viklund, M., Fredriksson, J., Holdfeldt, A., Lind, S., Franzyk, Henrik, Dahlgren, C., Sundqvist, M. & Forsman, H., 2022, In: Journal of Immunology. 208, 7, p. 1632-1641Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.Research output: Contribution to conference › Poster › Research
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Structure-Activity Study of alpha-Peptoid/alpha-Peptide Peptidomimetics: Influence of Hydrophobicity on Antimicrobial Activity and Cytotoxicity
Frederiksen, N., Bjorkling, F., Nielsen, P. & Franzyk, Henrik, Sep 2018, In: Journal of Peptide Science. 24, s2, p. S120-S120Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function
Holdfeldt, A., Skovbakke, S. L., Gabl, M., Nielsen, C., Dahlgren, C., Franzyk, Henrik & Forsman, H., 28 Mar 2019, In: ACS Omega. 4, 3, p. 5968-5982 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues
Shaikh, Ashif Yasin, Björkling, Fredrik, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Kreicberga, A. & Franzyk, Henrik, 2023, In: Bioorganic Chemistry. 141, 11 p., 106876.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)
Couturier, C., Ronzon, Q., Lattanzi, G., Lingard, I., Coyne, S., Cazals, V., Dubarry, N., Yvon, S., Leroi-Geissler, C., Gracia, O. R., Teague, J., Sordello, S., Corbett, D., Bauch, C., Monlong, C., Payne, L., Taillier, T., Fuchs, H., Broenstrup, M., Harrison, P. H. & 10 others, , 2024, In: European Journal of Medicinal Chemistry. 265, 20 p., 116097.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on acid stability and solid-phase block synthesis of peptide-peptoid hybrids: ligands for formyl peptide receptors
Hansen, A. M., Skovbakke, S. L., Christensen, S. B., Perez-Gassol, I. & Franzyk, Henrik, 2019, In: Amino Acids. 51, p. 205-218Research output: Contribution to journal › Journal article › Research › peer-review
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Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23-24, p. 1109 1 p., A81.Research output: Contribution to journal › Conference abstract in journal › Research
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Studies towards improved stability and permeability of a cell-penetrating peptide
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Journal of Peptide Science. 16, p. 148 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
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Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins
Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.Research output: Contribution to journal › Journal article › Research
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Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro
Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices
Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic peptidomimetic-antimicrobial combinations to combat multidrug-resistant Gram-negative bacterial infections
Baker, K. R., Jana, B., Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy
Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
Synthesis of Antirrhinolide, a New Lactone from Antirrhinum majus
Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., 1998, In: European Journal of Organic Chemistry. p. 1665-1667 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of Antirrhinolide, a New Lactone fromAntirrhinum Majus
Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., Aug 1998, In: European Journal of Organic Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of Carbocyclic Homo-N-nucleosides from Iridoids
Franzyk, Henrik, Rasmussen, J. H., Mazzei, R. A. & Jensen, S. R., 1998, In: European Journal of Organic Chemistry. p. 2931-2935 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of Monoterpene Piperidines from the Iridoid Glucoside Antirrhinoside
Franzyk, Henrik, Frederiksen, S. M. & Jensen, S. R., 1997, In: Journal of Natural Products. 60, p. 1012-1016 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of aliphatic O-dimannosyl amino acid building blocks for solid-phase assembly of glycopeptide libraries
Franzyk, Henrik, Meldal, M., Paulsen, H. & Bock, K., 1995, In: Journal of the Chemical Society, Perkin Transactions 1. 36, 9, p. 2883-2898 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A
Franzyk, Henrik, Jensen, S. R., Olsen, C. E. & Rasmussen, J. H., 2002, In: Nucleosides, Nucleotides and Nucleic Acids. 21, 1, p. 23-43 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthetic aspects of iridoid chemistry
Franzyk, Henrik, 2000, In: Fortschritte der Chemie Organischer Naturstoffe. 79, p. 1-114 114 p.Research output: Contribution to journal › Review › Research
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Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli
Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
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2002
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
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1600
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
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1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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