Jan Stenvang
Associate Professor
Translational and Clinical Pharmacology
Jagtvej 160
2100 København Ø
- 1999
- Published
Conserved residues and their role in the structure, function, and stability of acyl-coenzyme A binding protein
Kragelund, B. B., Poulsen, K., Andersen, K. V., Baldursson, T., Krøll, J. B., Neergård, T. B., Jepsen, J., Roepstorff, P., Kristiansen, Karsten, Poulsen, F. M., Knudsen, J. & Stenvang, Jan, 1999, In: Biochemistry. 38, 8, p. 2386-94 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA)
Stenvang, Jan, Pfundheller, H. M. & Lykkesfeldt, A. E., 2004, In: Oligonucleotides. 14, 2, p. 147-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology
Stenvang, Jan, Sørensen, M. D. & Wengel, J., 2004, In: Oligonucleotides. 14, 2, p. 130-46 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA)
Vollmer, J., Uhlmann, E., Stenvang, Jan, Schetter, C., Jurk, M., Wader, T., Wüllner, M. & Krieg, A. M., 2004, In: Oligonucleotides. 14, 1, p. 23-31 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment.
Christensen, G. L., Stenvang, Jan, Fog, C. K., Christensen, I. J. & Lykkesfeldt, A. E., 2004, In: Breast Cancer Research and Treatment. p. 53–63Research output: Contribution to journal › Journal article › Research › peer-review
LNA-antisense rivals siRNA for gene silencing
Stenvang, Jan & Wengel, J., Mar 2004, In: Current Opinion in Drug Discovery & Development. 7, 2, p. 188-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)
Hrdlicka, P. J., Stenvang, Jan & Wengel, J., 2005, In: Nucleosides, nucleotides & nucleic acids. 24, 5-7, p. 397-400 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)
Hrdlicka, P. J., Jepsen, J. S., Nielsen, C., Wengel, J. & Stenvang, Jan, 15 Feb 2005, In: Bioorganic & Medicinal Chemistry. 13, 4, p. 1249-60 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)
Hrdlicka, P. J., Andersen, N. K., Stenvang, Jan, Hansen, F. G., Haselmann, K. F., Nielsen, C. & Wengel, J., 1 Apr 2005, In: Bioorganic & Medicinal Chemistry. 13, 7, p. 2597-621 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator
Juncker-Jensen, A., Lykkesfeldt, A. E., Worm, J., Ralfkiær, U., Espelund, U. & Stenvang, Jan, 1 Aug 2006, In: Growth Hormone and IGF Research. 16, 4, p. 224-239 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer
Rasmussen, L. M., Zaveri, N. T., Stenvang, Jan, Peters, R. H. & Lykkesfeldt, A. E., 2007, In: Breast Cancer Research and Treatment. 106, 2, p. 191-203 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Yde, C. W., Frogne, T., Lykkesfeldt, A. E., Fichtner, I., Issinger, O. G. & Stenvang, Jan, 2007, In: Cancer Letters. 256, 2, p. 229-237 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells
Frankel, Lisa, Lykkesfeldt, A. E., Hansen, J. B. H. & Stenvang, Jan, 2007, In: Breast Cancer Research and Treatment. 104, 2, p. 165-179 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death
Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
MicroRNAs as targets for antisense-based therapeutics
Stenvang, Jan & Kauppinen, M. S., 2008, In: Expert Opinion on Biological Therapy. 8, 1, p. 59-81 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting of microRNAs for therapeutics
Stenvang, Jan, Lindow, M. & Kauppinen, S., 2008, In: Biochemical Society Transactions. 36, Pt 6, p. 1197-200 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The utility of LNA in microRNA-based cancer diagnostics and therapeutics
Stenvang, Jan, Silahtaroglu, Asli, Lindow, M., Elmen, J. & Kauppinen, S., 2008, In: Seminars in Cancer Biology. 18, 2, p. 89-102 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4
Sonkoly , E., Janson , P., Majuri , M., Savinko , T., Fyhrquist , N., Eidsmo , L., Xu , N., Meisgen , F., Wei , T., Bradley , M., Stenvang, Jan, Kauppinen , S., Alenius, H., Lauerma , A., Homey , B., Winqvist , O., Ståhle , M. & Pivarcsi , A., 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNAs, epigenetics and disease
Silahtaroglu, Asli & Stenvang, Jan, 2010, In: Essays in Biochemistry. 48, 1, p. 165-185 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Submitted
MicroRNA profiling in generated oxaliplatin- and SN-38-resistant colorectal cancer cell lines
Jensen, N. F., Søkilde, R., Stenvang, Jan, Litman, T., Brunner, N. & Rømer, M. U. K., 2011, (Submitted). 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
Silencing of microRNA families by seed-targeting tiny LNAs
Obad, S., dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, Jan, Straarup, E. M., Hansen, H. F., Koch, T., Pappin, D., Hannon, G. J. & Kauppinen, S., 2011, In: Nature Genetics. 43, 4, p. 371-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiplexed homogeneous proximity ligation assays for high throughput protein biomarker research in serological material
Lundberg, M., Thorsen, S. B., Assarsson, E., Villablanca, A., Tran, B., Gee, N., Knowles, M., Nielsen, B. E. S., Couto, E. G., Martin, R., Nilsson, O., Fermer, C., Schlingemann, J., Christensen, I. J., Nielsen, H. J., Ekstrom, B., Andersson, C., Gustafsson, M., Brünner, N., Stenvang, J. & 1 others, , Apr 2011, In: Molecular and Cellular Proteomics. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
Eskildsen, T., Taipaleenmäki, H., Stenvang, Jan, Abdallah, B., Ditzel, N., Nossent, Anne Yaël, Bak, M., Kauppinen, S. & Kassem, M., 12 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Inhibition of microRNA function by antimiR oligonucleotides
Stenvang, Jan, Petri, A., Lindow, M., Obad, S. & Kauppinen, S., 2012, In: Silence. 3, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The therapeutic potential of MicroRNAs in cancer
Thorsen, S. B., Obad, S., Jensen, N. F., Stenvang, Jan & Kauppinen, S., 2012, In: Cancer Journal. 18, 3, p. 275-284 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
A systematic review on topoisomerase 1 inhibition in the treatment of metastatic breast cancer
Kümler, I., Brünner, N., Stenvang, Jan, Balslev, E. & Nielsen, D. L., 2013, In: Breast Cancer Research and Treatment. 138, 2, p. 347-358 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development
Stenvang, Jan, Kümler, I., Nygård, S. B., Smith, D. H., Nielsen, D., Brünner, N. & Moreira, José, 2013, In: Frontiers in Oncology. 3, 9 p., 313.Research output: Contribution to journal › Review › Research › peer-review
- Published
High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer
Rasmussen, M. H., Jensen, N. F., Tarpgaard, L. S., Qvortrup, C., Rømer, M. U. K., Stenvang, Jan, Hansen, T. P., Christensen, L. L., Lindebjerg, J., Hansen, F., Jensen, B. V., Hansen, T. F., Pfeiffer, P., Brünner, N., Ørntoft, T. F. & Andersen, C. L., 2013, In: Molecular Oncology. 7, 3, p. 637-646 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties
Lin, X., Li, J., Yin, G., Zhao, Q., Elias, D., Lykkesfeldt, A., Stenvang, Jan, Brünner, N., Wang, J., Yang, H., Bolund, L. & Ditzel, H. J., 2013, In: Breast cancer research : BCR. 15, 6, 17 p., R119.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study
Thorsen, S. B., Christensen, Sarah Louise T, Würtz, S. Ø., Lundberg, M., Nielsen, B. E. S., Jensen, L. V., Knowles, M., Gee, N., Fredriksson, S., Møller, S., Brünner, N., Rasmussen, A. S. & Stenvang, Jan, 2013, In: B M C Cancer. 13, 12 p., 598.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proximity probing assays for simultaneous visualization of protein complexes in situ
Moreira, José, Thorsen, S. B., Brünner, N. & Stenvang, Jan, 2013, In: Expert Review of Proteomics. 10, 3, p. 219-221 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TIMP-1 overexpression does not affect sensitivity to HER2-targeting drugs in the HER2-gene-amplified SK-BR-3 human breast cancer cell line
Deng, X., Fogh, L., Lademann, U. A., Jensen, V., Stenvang, Jan, Yang, H., Brünner, N. & Rasmussen, A. S., 2013, In: Tumor Biology. 34, 2, p. 1161-1170 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression
Bjerre, C. A., Jensen, L. V., Belling, K. C., Würtz, S. Ø., Yadav, R., Lademann, U. A., Rigina, O., Do, K. N., Ditzel, H. J., Lykkesfeldt, A. E., Wang, J., Nielsen, H. B., Brünner, N., Gupta, R., Rasmussen, A. S. & Stenvang, Jan, 2013, In: Tumor Biology. 34, 6, p. 3839-3851 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells
Hekmat, O., Munk, S., Fogh, L., Yadav, R., Francavilla, C., Horn, H., Würtz, S. Ø., Schrohl, A-S., Damsgaard, B., Romer, M. U., Belling, K., Jensen, N. F., Gromova, I., Bekker-Jensen, D. B., Moreira, J., Jensen, L. J., Gupta, R., Lademann, U. A., Brünner, N., Olsen, J. V. & 1 others, , 5 Aug 2013, In: Journal of Proteome Research. 12, 9, p. 4136-4151 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability
Assarsson, E., Lundberg, M., Holmquist, G., Björkesten, J., Thorsen, S. B., Ekman, D., Eriksson, A., Rennel Dickens, E., Ohlsson, S., Edfeldt, G., Andersson, A., Lindstedt, P., Stenvang, Jan, Gullberg, M. & Fredriksson, S., 2014, In: PLOS ONE. 9, 4, 11 p., e95192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody
Smith, D. H., Fiehn, A. K., Fogh, L., Christensen, I. J., Hansen, T. P., Stenvang, Jan, Nielsen, H. J., Nielsen, K. V., Hasselby, J. P., Brünner, N. & Jensen, S. S., 2014, In: Scientific Reports. 4, p. 1-8 8 p., 4313.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No effect of ablation of surfactant protein-D on acute cerebral infarction in mice
Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, Jan, Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., 2014, In: Journal of Neuroinflammation. 11, 13 p., 123.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma
Guil-Luna, S., Stenvang, Jan, Brünner, N., De Andrés, F. J., Rollón, E., Domingo, V., Sánchez-Céspedes, R., Millán, Y. & Mulas, J. M. D. L., 2014, In: B M C Veterinary Research. 10, 8 p., 296.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Progesterone receptor isoform analysis by quantitative real-time polymerase chain reaction in formalin-fixed, paraffin-embedded canine mammary dysplasias and tumors
Guil-Luna, S., Stenvang, Jan, Brünner, N., Sánchez-Céspedes, R., Millán, Y., Gómez-Laguna, J. & Mulas, J. M. D. L., 2014, In: Veterinary Pathology. 51, 5, p. 895-902 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells
Jensen, L. V., Lademann, U. A., Andersen, E. V., Højrup, P., Thaysen-Andersen, M., Krogh, B. O., Viuff, B. M., Brünner, N., Stenvang, Jan & Moreira, José, 2014, In: Protein Expression and Purification. 101, p. 157-164 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol
Kümler, Iben, Balslev, E., Stenvang, Jan, Brünner, N. & Nielsen, D., 2015, In: B M C Cancer. 15, 5 p., 78.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways
Hansen, S. N., Westergaard, David, Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, K. G., Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, José, Brünner, N., Stenvang, Jan & Rasmussen, A. S., 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of a new TIMP-1 binding protein
Moreira, José, Høeberg, M., Lademann, U. A., Viuff, B. M., Jensen, L. V., Stenvang, Jan, Nygård, S. B., Ørum-Madsen, M. S., Vistesen, M. V., Fuglsang, Anja Thoe, Liu, S. & Brünner, N., 2015, In: Cancer Research. 75, 9 suppl., 1 p., Abstract P5-07-08.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas
Grunnet, M., Calatayud, D., Schultz, N. A., Hasselby, Jane Preuss, Mau-Sørensen, M., Brünner, N. & Stenvang, Jan, 2015, In: Scandinavian Journal of Gastroenterology. 50, 4, p. 485-494 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The potential role of Alu Y in the development of resistance to SN38 (Irinotecan) or oxaliplatin in colorectal cancer
Lin, X., Stenvang, Jan, Rasmussen, M. H., Zhu, S., Jensen, N. F., Tarpgaard, L. S., Yang, G., Belling, K., Andersen, C. L., Li, J., Bolund, L. & Brünner, N., 2015, In: BMC Genomics. 16, 17 p., 404.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance
Jensen, N. F., Stenvang, J., Beck, M. K., Hanáková, B., Belling, K. C., Do, K. N., Viuff, B. M., Nygård, S. B., Gupta, R., Rasmussen, M. H., Tarpgaard, L. S., Hansen, T. P., Budinská, E., Pfeiffer, P., Bosman, F., Tejpar, S., Roth, A., Delorenzi, M., Andersen, C. L., Rømer, M. U. K. & 2 others, , 24 Feb 2015, In: Molecular Oncology. 9, 6, p. 1169-1185 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers
Sønderstrup, I. M. H., Nygård, S. B., Poulsen, T. S., Linnemann, D., Stenvang, Jan, Nielsen, H. J., Bartek, J., Brünner, N., Nørgaard, P. & Riis, Lene Buhl, 4 Mar 2015, In: Molecular Oncology. 9, 6, p. 1207-1217 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer
Kümler, I., Balslev, E., Poulsen, T. S., Nielsen, Signe Lykke, Nygård, S. B., Rømer, M. U., Christensen, I. J., Høgdall, E., Moreira, José, Nielsen, Dorte Lisbet, Brünner, N. & Stenvang, Jan, 8 Apr 2015, In: International Journal of Cancer. 137, 8, p. 2000-2006 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug transporters in breast cancer: response to anthracyclines and taxanes
Kümler, I., Stenvang, Jan, Moreira, José, Brünner, N. & Nielsen, Dorte Lisbet, Sep 2015, In: Expert Review of Anticancer Therapy. 15, 9, p. 1075-1092 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12922
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1958
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MicroRNAs, epigenetics and disease
Research output: Contribution to journal › Journal article › Research › peer-review
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1685
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Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1391
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Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma
Research output: Contribution to journal › Journal article › Research › peer-review
Published