Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor

ORCID: 0000-0002-5613-1267

Publication year:
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1 - 100 out of 145Page size: 100
  1. 1998
  2. Published

    Palladium-Catalyzed Arylation and Acylation of 1-Benzyloxy-1,2,3-triazole Through a Directed Ortho Lithiation-Transmetalation Strategy.

    Felding, J., Uhlmann, P., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1998, In: Synthesis. 8, p. 1181-1184 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling

    Kristensen, Jesper Langgaard, Begtrup, M. & Vedsø, P., 1 Nov 1998, In: Synthesis. 11, p. 1604-1608 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 1999
  5. Published

    Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole

    Felding, J., Kristensen, Jesper Langgaard, Bjerregaard, T., Sander, L., Vedsø, P. & Begtrup, M., 28 May 1999, In: Journal of Organic Chemistry. 64, 11, p. 4196-4198 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2001
  7. Published

    Synthesis of Ortho Substituted Arylboronic Esters by in Situ Trapping of Unstable Lithio Intermediates

    Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 17 May 2001, In: Organic Letters. 3, 10, p. 1435-1437 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  8. Published

    Convergent synthesis of 3-arylated 1-hydroxypyrazoles via 3-metalated pyrazole-1-oxides

    Eskildsen, J., Kristensen, Jesper Langgaard, Vedsø, P., Begtrup, M. & Kristensen, Jesper Langgaard, 14 Dec 2001, In: Journal of Organic Chemistry. 66, 25, p. 8654-8656 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2002
  10. Published

    Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

    Lysén, M., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1 Jan 2002, In: Organic Letters. 4, 2, p. 257-259 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Nonracemic, chiral homoenolate reagents derived from (cycloalk-1-enyl)methyl carbamates and evaluation of their configurational stabilities

    Özlügedik, M., Kristensen, Jesper Langgaard, Wibbeling, B., Fröhlich, R. & Hoppe, D., 1 Jan 2002, In: European Journal of Organic Chemistry. 3, p. 414-427 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Synthesis of novel azaxanthones derived from N-hydroxyazoles

    Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 18 Mar 2002, In: Tetrahedron. 58, 12, p. 2397-2404 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones

    Trost, B. M., Schroeder, G. M. & Kristensen, Jesper Langgaard, 16 Sep 2002, In: Angewandte Chemie International Edition. 41, 18, p. 3492-3495 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2003
  15. Published

    Synthesis of pentacyclic 13-azadibenzo[a,de]anthracenes via anionic cascade ring closure

    Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 16 May 2003, In: Journal of Organic Chemistry. 68, 10, p. 4091-4092 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2004
  17. Published

    Ny bioisoster kan skabe nye lægemidler

    Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2004, In: Lægemiddelforskning. 2004, p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  18. Published

    Stereoselective synthesis of highly substituted bicyclic γ-lactones using homoaldol addition of 1-(1-cycloalkenyl)methyl carbamates

    Özlügedik, M., Kristensen, Jesper Langgaard, Reuber, J., Fröhlich, R. & Hoppe, D., 1 Oct 2004, In: Synthesis. 14, p. 2303-2316 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Deprotection of 2-nitrobenzenesulfonamides using fluorous and solid phase reagents

    rtc312, rtc312, Clausen, Rasmus Prætorius, Begtrup, M. & Kristensen, Jesper Langgaard, 18 Oct 2004, In: Tetrahedron Letters. 45, 43, p. 7991-7993

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2005
  21. Published

    Synthesis of ortho substituted arylboronic esters by in situ trapping of unstable lithio intermediates: 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-YL)Benzoic acid ethyl ester: [Benzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-, ethyl ester]

    Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 1 Jan 2005, In: Organic Syntheses. 81, p. 134-139 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides

    Lysén, M., Kelleher, S., Begtrup, M. & Kristensen, Jesper Langgaard, 24 Jun 2005, In: Journal of Organic Chemistry. 70, 13, p. 5342-5343 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations

    Søndergaard, K., Kristensen, Jesper Langgaard, Gillings, N. & Begtrup, M., 14 Oct 2005, In: European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synthesis of azaphenanthridines via anionic ring closure

    Hansen, H. M., Lysén, M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Oct 2005, In: Tetrahedron. 61, 42, p. 9955-9960 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synthesis and binding studies of 2-arylapomorphines

    Søndergaard, K., Kristensen, Jesper Langgaard, Palner, M., Gillings, N., Knudsen, Gitte Moos, Roth, B. & Begtrup, M., 21 Nov 2005, In: Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis

    Hansen, K. B., Clausen, Rasmus Prætorius, Bjerrum, E. J., Bechmann, C., Greenwood, J. R., Christensen, C., Kristensen, Jesper Langgaard, Egebjerg, J. & Bräuner, Hans, Dec 2005, In: Molecular Pharmacology. 68, 6, p. 1510-23

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2006
  28. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Synthesis of substituted 2-cyanoarylboronic esters

    Lysén, M., Hansen, H. M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Mar 2006, In: Journal of Organic Chemistry. 71, 6, p. 2518-20 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Synthesis, cross-coupling, and anionic cyclization of ortho-substituted naphthaleneboronic esters

    Lysén, M., Madden, M., Kristensen, Jesper Langgaard, Vedsø, P., Zöllner, C. & Begtrup, M., 17 Oct 2006, In: Synthesis. 20, p. 3478-3484 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2008
  32. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

    Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Synthesis of RHPS4 via an anionic ring closing cascade

    Kristensen, Jesper Langgaard, 2008, In: Tetrahedron Letters. 49, 15, p. 2351-2354

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2009
  35. Published

    Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides

    Bornholdt, J., Fjære, K. W., Felding, J. & Kristensen, Jesper Langgaard, 2009, In: Tetrahedron. 65, 45, p. 9280-9284

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Ind i hjernen med nye stoffer

    Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In: Lægemiddelforskning. p. 34-36

    Research output: Contribution to journal › Journal article › Communication

  37. 2010
  38. Published

    Amination of aryl iodides using a fluorous-tagged ammonia equivalent

    Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In: European Journal of Organic Chemistry. 2010, 19, p. 3704-3710

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for alpha1-adrenoceptors

    Kristensen, Jesper Langgaard, Pu¨schl, A., Jensen, M., Risgaard, R., Christoffersen, C. T., Bang-Andersen, B. & Balle, T., 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7021-7034

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships

    Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Nye NMDA-receptor-ligander til udforskning af hjernen

    Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In: Dansk Kemi. 91, 6/7, p. 21-23

    Research output: Contribution to journal › Journal article › Communication

  42. Published

    Ring opening of pymisyl-protected aziridines with organocuprates

    Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Synthesis and application of a new fluorous-tagged ammonia equivalent

    Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 15, p. 4557-4566

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Synthesis of enantiopure 3-substituted morpholines

    Bornholdt, J., Felding, J. & Kristensen, Jesper Langgaard, 2010, In: Journal of Organic Chemistry. 75, 21, p. 7454-7457

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  46. Published

    Histonhaler: et nyt mål inden for kræftbehandling

    Kristensen, Jesper Langgaard, Lohse, B. & Clausen, Rasmus Prætorius, Dec 2010, In: Lægemiddelforskning. 2010, p. 7-9

    Research output: Contribution to journal › Journal article › Communication

  47. 2011
  48. Published

    Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging

    Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Inhibitors of histone demethylases

    Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines

    Nielsen, S. D., Smith, G. P., Begtrup, M. & Kristensen, Jesper Langgaard, 22 Jul 2011, In: Tetrahedron. 67, 29, p. 5261-5267

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2012
  55. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journal › Journal article › Communication

  57. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Total synthesis of ascididemin via anionic cascade ring closure

    Petersen, I. N., Crestey, F. & Kristensen, Jesper Langgaard, 2012, In: Chemical Communications. 48, 72, p. 9092-9094

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In: Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)

    Leurs, U., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Lohse, B., 15 Sep 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. 2013
  64. Published

    Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

    Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

    Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Medicindepot dannes efter injektion i leddet

    Larsen, Susan Weng, Thing, M. A., Østergaard, Jesper, Kristensen, Jesper Langgaard, Hansen, M. & Larsen, C. S., 2013, In: Lægemiddelforskning. 2013, p. 38-40

    Research output: Contribution to journal › Journal article › Research

  67. Published

    Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

    Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936

    Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors

    Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In: P L o S One. 8, 11, e78515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists

    Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid

    Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36

    Ettrup, A., Holm, S., Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In: Molecular Imaging and Biology. 15, 4, p. 376-83

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor

    Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.

    Research output: Contribution to conference › Conference abstract for conference › Research

  74. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conference › Conference abstract for conference › Research

  75. Published

    PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591

    Research output: Patent

  76. Published

    Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide

    Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

    Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In: P L o S One. 8, 7, p. e67653

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. 2014
  79. Published

    A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection

    Thing, M., Agårdh, L., Larsen, Susan Weng, Rasmussen, R., Pallesen, J., Mertz, N., Kristensen, Jesper Langgaard, Hansen, M., Østergaard, Jesper & Larsen, C. S., 2014, In: Journal of Pharmaceutical Sciences. 103, 12, p. 4021–4029 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

    Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists

    Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In: A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Synthesis and SAR study of a novel series of dopamine receptor agonists

    Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Synthesis of Pyridoacridines through Anionic Cascade Ring Closure

    Petersen, I. N. & Kristensen, Jesper Langgaard, 1 Jan 2014, In: Synthesis. 46, p. 1469-1474 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Correlating the Metabolic Stability of Psychedelic 5-HT2A Agonists with Anecdotal Reports of Human Oral Bioavailability

    Leth-Petersen, S., Bundgaard, C., Hansen, M., Carnerup, M. A., Kehler, J. & Kristensen, Jesper Langgaard, 12 Feb 2014, In: Neurochemical Research. 39, 10, p. 2018-2023 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36

    Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

    Sköld, N., Nielsen, Birgitte, Olsen, J., Han, L., Olsen, L., Madsen, Ulf, Kristensen, Jesper Langgaard, Pickering, Darryl S & Johansen, Tommy Nørskov, 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes

    Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In: Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

    Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. 2015
  94. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

    Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner, Hans & Kristensen, Jesper Langgaard, 2015, In: Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, Mar 2015, In: Psychopharmacology. 232, 6, p. 1039-47 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

    Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs

    Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36

    Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  101. 2016
  102. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    Metabolic fate of hallucinogenic NBOMes

    Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    PRODRUGS OF NAPROXEN AND DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530

    Research output: Patent

  105. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. Published

    IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657

    Research output: Patent

  107. Published

    Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems

    Kruszyk, M., Jessing, M., Kristensen, Jesper Langgaard & Jorgensen, M., 13 May 2016, In: Journal of Organic Chemistry. 81, 12, p. 5128–5134 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  108. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

    Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  109. Published

    Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension

    Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  110. Published

    Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases

    Knuhtsen, A., Legrand, B., Van der Poorten, O., Amblard, M., Martinez, J., Ballet, S., Kristensen, Jesper Langgaard & Pedersen, D. S., 12 Aug 2016, In: Chemistry: A European Journal. 22, 39, p. 14022–14028 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  111. Published

    In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  112. Published

    5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism

    Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In: A C S Chemical Neuroscience. p. 1-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  113. 2017
  114. Published

    A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

    Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In: Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  115. Published

    Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH

    Nielsen, L. M., Holm, N. B., Leth-Petersen, S., Kristensen, Jesper Langgaard, Olsen, L. & Linnet, Kristian, 2017, In: Drug Testing and Analysis. 9, 5, p. 671–679

    Research output: Contribution to journal › Journal article › Research › peer-review

  116. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

    Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453

    Research output: Contribution to journal › Journal article › Research › peer-review

  117. Published

    Textbook of Drug Design and Discovery: In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  118. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices

    Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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