Jesper Langgaard Kristensen
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- 2013
- Published
Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Medicindepot dannes efter injektion i leddet
Larsen, Susan Weng, Thing, M. A., Østergaard, Jesper, Kristensen, Jesper Langgaard, Hansen, M. & Larsen, C. S., 2013, In: Lægemiddelforskning. 2013, p. 38-40Research output: Contribution to journal › Journal article › Research
- Published
Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes
Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936
Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors
Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In: P L o S One. 8, 11, e78515.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists
Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid
Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36
Ettrup, A., Holm, S., Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In: Molecular Imaging and Biology. 15, 4, p. 376-83Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor
Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772
Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591Research output: Patent
- Published
Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide
Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro
Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In: P L o S One. 8, 7, p. e67653Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection
Thing, M., Agårdh, L., Larsen, Susan Weng, Rasmussen, R., Pallesen, J., Mertz, N., Kristensen, Jesper Langgaard, Hansen, M., Østergaard, Jesper & Larsen, C. S., 2014, In: Journal of Pharmaceutical Sciences. 103, 12, p. 4021–4029 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes
Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists
Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In: A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and SAR study of a novel series of dopamine receptor agonists
Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Pyridoacridines through Anionic Cascade Ring Closure
Petersen, I. N. & Kristensen, Jesper Langgaard, 1 Jan 2014, In: Synthesis. 46, p. 1469-1474 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists
Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlating the Metabolic Stability of Psychedelic 5-HT2A Agonists with Anecdotal Reports of Human Oral Bioavailability
Leth-Petersen, S., Bundgaard, C., Hansen, M., Carnerup, M. A., Kehler, J. & Kristensen, Jesper Langgaard, 12 Feb 2014, In: Neurochemical Research. 39, 10, p. 2018-2023 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors
Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646Research output: Contribution to journal › Journal article › Research › peer-review
- Published
(11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand
Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36
Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites
Sköld, N., Nielsen, Birgitte, Olsen, J., Han, L., Olsen, L., Madsen, Ulf, Kristensen, Jesper Langgaard, Pickering, Darryl S & Johansen, Tommy Nørskov, 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes
Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In: Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry
Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists
Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner, Hans & Kristensen, Jesper Langgaard, 2015, In: Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
(11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand
Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice
Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, Mar 2015, In: Psychopharmacology. 232, 6, p. 1039-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors
Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs
Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888
Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36
Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2016
- Published
Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic fate of hallucinogenic NBOMes
Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PRODRUGS OF NAPROXEN AND DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530Research output: Patent
- Published
Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands
Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657Research output: Patent
- Published
Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems
Kruszyk, M., Jessing, M., Kristensen, Jesper Langgaard & Jorgensen, M., 13 May 2016, In: Journal of Organic Chemistry. 81, 12, p. 5128–5134 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C
Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension
Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases
Knuhtsen, A., Legrand, B., Van der Poorten, O., Amblard, M., Martinez, J., Ballet, S., Kristensen, Jesper Langgaard & Pedersen, D. S., 12 Aug 2016, In: Chemistry: A European Journal. 22, 39, p. 14022–14028 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism
Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In: A C S Chemical Neuroscience. p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In: Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH
Nielsen, L. M., Holm, N. B., Leth-Petersen, S., Kristensen, Jesper Langgaard, Olsen, L. & Linnet, Kristian, 2017, In: Drug Testing and Analysis. 9, 5, p. 671–679Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist
Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Textbook of Drug Design and Discovery: In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices
Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1305029
Most downloads
-
551
downloads
Convenient access to F-18-labeled amines through the Staudinger reduction
Research output: Contribution to journal › Conference abstract in journal › Research
Published -
331
downloads
A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
223
downloads
Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
Research output: Contribution to journal › Journal article › Research › peer-review
Published