Jette Sandholm Jensen Kastrup
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
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Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution
Rasmussen, H. B., Kastrup, Jette Sandholm Jensen, Nielsen, J. N., Nielsen, J. M. & Nielsen, Peter E., 1997, In: Nature Structural and Molecular Biology. 4, p. 98-101 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals
Rasmussen, H. B., Liljefors, T., Petersson, B., Nielsen, Peter E., Liljefors, T. & Kastrup, Jette Sandholm Jensen, Feb 2004, In: Journal of Biomolecular Structure & Dynamics. 21, 4, p. 495-502 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.
Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011Research output: Other contribution › Research
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Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259Research output: Contribution to journal › Journal article › Research › peer-review
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High resolution crystal structures of the p120 RasGAP SH3 domain
Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype
Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501
Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands
Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482Research output: Contribution to journal › Journal article › Research › peer-review
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Snegleprotein øger forståelsen af vigtige receptorer i hjernen
Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.Research output: Contribution to journal › Journal article › Communication
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Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate
Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism
Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757Research output: Contribution to journal › Journal article › Research › peer-review
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Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity
Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom
Skov, L. K., Seppälä, U., Coen, J. J. F., Crickmore, N., King, T. P., Monsalve, R., Kastrup, Jette Sandholm Jensen, Spangfort, M. D. & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 6, p. 595-604 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion
Soroka, V., Kolkova, K., Kastrup, Jette Sandholm Jensen, Diederichs, K., Breed, J., Kiselyov, V., Poulsen, F. M., Larsen, I. K., Welte, W., Berezin, V., Bock, E. & Kasper, C., 2003, In: Structure. 10, p. 1291-1301Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis
Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
Szymanska, E., Frydenvang, Karla Andrea, Pickering, Darryl S, Krintel, C., Nielsen, Birgitte, Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure
Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298Research output: Contribution to journal › Journal article › Research › peer-review
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The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region
Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In: Scientific Reports. 7, 12 p., 46145.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists
Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951Research output: Contribution to journal › Journal article › Research › peer-review
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Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate
Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Dec 2011, In: Journal of Structural Biology. 176, 3, p. 307-314Research output: Contribution to journal › Journal article › Research › peer-review
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Kainate induces various domain closures in AMPA and kainate receptors
Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545Research output: Contribution to journal › Journal article › Research › peer-review
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Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization
Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Novellino, E., Campiani, G. & Pickering, Darryl S, 14 Jul 2011, In: Journal of Medicinal Chemistry. 54, 13, p. 4793-4805Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain
Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
Venskutonyte, R., Frydenvang, Karla Andrea, Valadés, E. A., Szymanska, E. M., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1298590
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
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