Kasper Harpsøe
Research consultant
Biopharmaceuticals
Jagtvej 162, 2100 København Ø
- 2011
- Published
Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene
Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011Research output: Other contribution › Research
- 2012
- Published
Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides
Ambrus, J. I., Halliday, J. I., Kanizaj, N., Absalom, N., Harpsøe, Kasper, Balle, T., Chebib, M. & McLeod, M. D., 7 Jul 2012, In: Chemical Communications. 48, 53, p. 6699-6701 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nyt bindingssted i nikotine acetylcholinreceptorer: håb om ny behandling af eksempelvis ADHD og Alzheimers sygdom
Harpsøe, Kasper & Balle, T., Feb 2012, In: BestPractice Psykiatri/Neurologi. 5, 16, p. 7-10 4 p.Research output: Contribution to journal › Journal article › Communication
- Published
Structure-activity relationships for negative allosteric mGluR5 modulators
Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators
Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A robust force field based method for calculating conformational energies of charged drug-like molecules
Pøhlsgaard, J., Harpsøe, Kasper, Jørgensen, Flemming Steen & Olsen, L., 2012, In: Journal of Chemical Information and Modeling. 52, 2, p. 409-419Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a novel allosteric modulator of 5-HT3 receptor: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site
Trattnig, S. M., Harpsøe, Kasper, Thygesen, S. B., Rahr, L. M., Ahring, P. K., Balle, T. & Jensen, Anders A., 2012, In: Journal of Biological Chemistry. 287, 30, p. 25241-25254Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor: ANTAGONIST BINDING SITE AND MODE OF RECEPTOR INHIBITION REVEALED
Absalom, N. L., Quek, G., Lewis, T. M., Qudah, T., von Arenstorff, I., Ambrus, J. I., Harpsøe, Kasper, Karim, N., Balle, T., McLeod, M. D. & Chebib, M., 13 Sep 2013, In: The Journal of Biological Chemistry. 288, 37, p. 26521-32 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1428429
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Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
Research output: Contribution to journal › Journal article › Research › peer-review
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318
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GPCRdb: an information system for G protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
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279
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Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
Research output: Contribution to journal › Journal article › Research › peer-review
Published