Lasse Kristoffer Bak
Guest Researcher, Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
TG IV
Jagtvej 160
2100 København Ø
- Published
A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures
Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Amino acid neurotransmitter synthesis and removal
Schousboe, Arne, Bak, Lasse Kristoffer, Madsen, K. K. & Waagepetersen, Helle S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure
Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation
Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Aspects of astrocytic cAMP signaling with an emphasis on the putative power of compartmentalized signals in health and disease
Christiansen, Ann-Kathrin Lindahl, Jakobsen, Emil, Mertz, C. & Bak, Lasse Kristoffer, 2019, In: Glia. 67, 9, p. 1625-1636Research output: Contribution to journal › Review › Research › peer-review
- Published
Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target
Mertz, C., Krarup, S., Jensen, C. D., Lindholm, S. E. H., Kjær, C., Pinborg, Lars Hageman & Bak, Lasse Kristoffer, 2020, In: Neurochemical Research. 45, p. 1247-1255 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis
Müller, M. S., Fox, R., Schousboe, Arne, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytes take the stage in a tale of signaling-metabolism coupling
Bak, Lasse Kristoffer, 2 Jun 2017, In: The Journal of Biological Chemistry. 292, 22, p. 9439-9440 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA
Schousboe, Arne, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 15 Aug 2013, In: Frontiers in Endocrinology. 4, 102.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic glycogen metabolism in the healthy and diseased brain
Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures
Dadsetan, S., Kukolj, E., Bak, Lasse Kristoffer, Sørensen, M., Ott, P., Vilstrup, H., Schousboe, Arne, Keiding, S. & Waagepetersen, Helle S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects
Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons
Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61Research output: Contribution to journal › Journal article › Research › peer-review
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Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?
Bak, Lasse Kristoffer, Christiansen, Ann-Kathrin Lindahl, Kjaer, C., Jakobsen, Emil, Hedehus, J., Mertz, C., Madsen, S., Jensen, M., Bergstedt, N., Knezevic, A. & Lindholm, S., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry
Müller, M. S., Obel, L. L. F., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, Jun 2013, In: Neurochemical Research. 38, 6, p. 1260-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes
Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain
Bak, Lasse Kristoffer & Walls, Anne Byriel, 1 Feb 2018, In: The Journal of Physiology. 596, 3, p. 351-353 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools
Sonnewald, U., Kortner, T. M., Qu, H., Olstad, E., Suñol, C., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 7 Mar 2006, In: Neurochemistry International. 48, 6-7, p. 572-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine
Leke, R., Bak, Lasse Kristoffer, Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1303653
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
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321
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Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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195
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Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes
Research output: Contribution to conference › Poster › Research
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