Lasse Kristoffer Bak
Guest Researcher, Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
TG IV
Jagtvej 160
2100 København Ø
- 2013
- Published
Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia
Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy
Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2012
- Published
Primary cultures of astrocytes: their value in understanding astrocytes in health and disease
Lange, S. C., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation
Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Effects of adrenergic agents on intracellular ca(2+) homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity
Obel, L. L. F., Andersen, K. M. H., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Neurotoxicity Research. 21, 4, p. 405-17 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats
Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Keiding, S., Schousboe, Arne & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons
Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons
Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons
Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects
Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy
Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine
Leke, R., Bak, Lasse Kristoffer, Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Glutamate and glutamine in brain disorders
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The Value of Example Solutions in Pharmacy Education: The role of seniority and gender.
Sandelin, Albin Gustav, Hansen, H. R., Baldursdóttir, S. G., Kristensen, Anders Skov, Bak, Lasse Kristoffer, Christiansen, Frederik Voetmann & Selhuber-Unkel, C. J. M., 2011, In: Pharmacy Education. 11, 1, p. 32-37 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient
Schousboe, Arne, Sickmann, H. M., Walls, Anne Byriel, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2010, In: Neurotoxicity Research. 18, 1, p. 94-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Erratum: Demonstration of neuron-glia transfer of precursors for gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex (Neurochem Res (2008) 33:26292635;DOI 10.1007/s11064-008-9814-6)
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 1 Dec 2009, In: Neurochemical Research. 34, 12, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Impact of the malate-aspartate shuttle in glutamate neurotransmission
Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy
Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia
Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels
Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy
Keiding, S., Iversen, P., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Gjedde, A., Schousboe, Arne & Vilstrup, H., 2009, In: Journal of Neurochemistry. s1, p. 269-270Research output: Contribution to journal › Conference abstract in journal › Research
- 2008
- Published
Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix
Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate
Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., Dec 2007, In: Neurotoxicity Research. 12, 4, p. 263-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure
Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes
Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energy substrates to support glutamatergic and GABAergic synaptic function: Role of glycogen, glucose and lactate
Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., 2007, In: Neurotoxicity Research. 12, 4, p. 263-268Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes
Johansen, M. L., Bak, Lasse Kristoffer, Schousboe, Arne, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Gjedde, A., Ott, P. & Waagepetersen, Helle S., 2007, In: Neurochemistry International. 50, p. 1042-1051Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons
Bak, Lasse Kristoffer, Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Oct 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 10, p. 1285-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools
Sonnewald, U., Kortner, T. M., Qu, H., Olstad, E., Suñol, C., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 7 Mar 2006, In: Neurochemistry International. 48, 6-7, p. 572-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)
Bröer, A., Tietze, N., Kowalczuk, S., Chubb, S., Munzinger, M., Bak, Lasse Kristoffer & Bröer, S., 1 Jan 2006, In: Biochemical Journal. 393, Pt 1, p. 421-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures
Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission
Schousboe, Arne, Sarup, A., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Larsson, O. M., Sep 2004, In: Neurochemistry International. 45, 4, p. 521-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures
Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, Jan 2004, In: Neurochemical Research. 29, 1, p. 257-65 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1303653
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
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Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?
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Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes
Research output: Contribution to conference › Poster › Research
Published