Lasse Kristoffer Bak

Lasse Kristoffer Bak

Guest Researcher, Professor

ORCID: 0000-0003-0784-7864

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  1. Published

    Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

    Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, Kristine, 2017, In: Stem Cell Reports. 8, 3, p. 648-658

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex

    Westi, Emil Winther, Jakobsen, Emil, Voss, C. M., Bak, Lasse Kristoffer, Pinborg, Lars Hageman, Aldana, Blanca & Andersen, J. V., 2022, In: Molecular Neurobiology. 59, p. 7495–7512

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)

    Walls, Anne Byriel, Bak, Lasse Kristoffer, Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission

    Walls, Anne Byriel, Flynn, S. P., West, P. J., Müller, M. S., Bak, Lasse Kristoffer, Bulaj, G., Schousboe, Arne & White, H. S., Mar 2016, In: Epilepsy Research. 121, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The Glutamine-Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

    Walls, Anne Byriel, Waagepetersen, Helle S., Bak, Lasse Kristoffer, Schousboe, Arne & Sonnewald, U., Feb 2015, In: Neurochemical Research. 40, 2, p. 402-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Is neuronal utilization of glucose and lactate linked to Ca2+-dependent modulation of malate-aspartate shuttle activity?

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Walls, Anne Byriel & Schousboe, Arne, 2008.

    Research output: Contribution to conference › Poster › Research

  7. Published

    Impact of the malate-aspartate shuttle in glutamate neurotransmission

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9

    Research output: Contribution to journal › Conference abstract in journal › Research

  8. Published

    Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone

    Sorensen, M., Walls, Anne Byriel, Dam, G., Bak, Lasse Kristoffer, Andersen, Jens Velde, Ott, P., Vilstrup, H. & Schousboe, Arne, 2022, In: Analytical Biochemistry. 654, 4 p., 114766.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools

    Sonnewald, U., Kortner, T. M., Qu, H., Olstad, E., Suñol, C., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 7 Mar 2006, In: Neurochemistry International. 48, 6-7, p. 572-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate

    Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., Dec 2007, In: Neurotoxicity Research. 12, 4, p. 263-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA

    Schousboe, Arne, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 15 Aug 2013, In: Frontiers in Endocrinology. 4, 102.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289

    Research output: Contribution to journal › Conference abstract in journal › Research

  13. Published

    Glutamate metabolism in the brain focusing on astrocytes

    Schousboe, Arne, Scafidi, S., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

    Schousboe, Arne, Waagepetersen, Helle S., Leke, R. & Bak, Lasse Kristoffer, 1 Mar 2014, In: Metabolic Brain Disease. 29, 4, p. 913-917 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

    Schousboe, Arne, Sickmann, H. M., Walls, Anne Byriel, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2010, In: Neurotoxicity Research. 18, 1, p. 94-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Amino acid neurotransmitter synthesis and removal

    Schousboe, Arne, Bak, Lasse Kristoffer, Madsen, K. K. & Waagepetersen, Helle S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  17. Published

    Energy substrates to support glutamatergic and GABAergic synaptic function: Role of glycogen, glucose and lactate

    Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., 2007, In: Neurotoxicity Research. 12, 4, p. 263-268

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

    Schousboe, Arne, Sarup, A., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Larsson, O. M., Sep 2004, In: Neurochemistry International. 45, 4, p. 521-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism

    Satrústegui, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2425-30 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The Value of Example Solutions in Pharmacy Education: The role of seniority and gender.

    Sandelin, Albin Gustav, Hansen, H. R., Baldursdóttir, S. G., Kristensen, Anders Skov, Bak, Lasse Kristoffer, Christiansen, Frederik Voetmann & Selhuber-Unkel, C. J. M., 2011, In: Pharmacy Education. 11, 1, p. 32-37 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma Cells

    Risborg Høyer, E., Demir, M., Bak, Lasse Kristoffer, Jørgensen, Niklas Rye & Agrawal, A., 2023, In: Receptors. 2, 3, p. 191-203

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Aspects of astrocytic cAMP signaling with an emphasis on the putative power of compartmentalized signals in health and disease

    Christiansen, Ann-Kathrin Lindahl, Jakobsen, Emil, Mertz, C. & Bak, Lasse Kristoffer, 2019, In: Glia. 67, 9, p. 1625-1636

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 26 Apr 2013, In: Neurochemical Research. 39, 3, p. 487-499

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level

    Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Effects of adrenergic agents on intracellular ca(2+) homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity

    Obel, L. L. F., Andersen, K. M. H., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Neurotoxicity Research. 21, 4, p. 405-17 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

    Nissen, J. D., Lykke, K., Bryk, J., Stridh, M. H., Zaganas, I., Jensen, Dorte Skytt, Schousboe, Arne, Bak, Lasse Kristoffer, Enard, W., Pääbo, S. & Waagepetersen, Helle S., 2017, In: Glia. 65, 3, p. 474–488

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry

    Müller, M. S., Obel, L. L. F., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, Jun 2013, In: Neurochemical Research. 38, 6, p. 1260-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

    Müller, M. S., Pedersen, Sofie E., Walls, Anne Byriel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Jan 2015, In: Glia. 63, 1, p. 154-62 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

    Müller, M. S., Fox, R., Schousboe, Arne, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target

    Mertz, C., Krarup, S., Jensen, C. D., Lindholm, S. E. H., Kjær, C., Pinborg, Lars Hageman & Bak, Lasse Kristoffer, 2020, In: Neurochemical Research. 45, p. 1247-1255 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells

    Lønsmann, I. & Bak, Lasse Kristoffer, Aug 2020, In: Cellular Signalling. 72, 5 p., 109635.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex

    Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

    Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Keiding, S., Schousboe, Arne & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Erratum: Demonstration of neuron-glia transfer of precursors for gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex (Neurochem Res (2008) 33:26292635;DOI 10.1007/s11064-008-9814-6)

    Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 1 Dec 2009, In: Neurochemical Research. 34, 12, 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

    Leke, R., Bak, Lasse Kristoffer, Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Dynamic changes in cytosolic ATP levels in cultured glutamatergic neurons during NMDA-induced synaptic activity supported by glucose or lactate

    Lange, S. C., Winkler, U., Andresen, Lars, Byhrø, M., Waagepetersen, Helle S., Hirrlinger, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2517-2526 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Primary cultures of astrocytes: their value in understanding astrocytes in health and disease

    Lange, S. C., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

    Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.

    Research output: Contribution to journal › Review › Research › peer-review

  42. Published

    Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy

    Krarup, S., Mertz, C., Jakobsen, Emil, Lindholm, S. E. H., Pinborg, Lars Hageman & Bak, Lasse Kristoffer, 2020, In: European Journal of Pharmacology. 886, 11 p., 173413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Differential Expression of the β3 Subunit of Voltage-Gated Ca2+ Channel in Mesial Temporal Lobe Epilepsy

    Kjær, C., Palasca, Oana, Barzaghi, G., Bak, Lasse Kristoffer, Durhuus, R. K. J., Jakobsen, Emil, Pedersen, Louise, Bartels, Emil Daniel, Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2023, In: Molecular Neurobiology. 60, p. 5755–5769

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Transcriptome analysis in patients with temporal lobe epilepsy

    Kjær, C., Barzaghi, G., Bak, Lasse Kristoffer, Goetze, Jens P. , Yde, C. W., Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2019, In: Brain. 142, 10, p. 49-64 16 p., e55.

    Research output: Contribution to journal › Letter › Research › peer-review

  45. Published

    Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy

    Keiding, S., Iversen, P., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Gjedde, A., Schousboe, Arne & Vilstrup, H., 2009, In: Journal of Neurochemistry. s1, p. 269-270

    Research output: Contribution to journal › Conference abstract in journal › Research

  46. Published

    The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

    Johansen, M. L., Bak, Lasse Kristoffer, Schousboe, Arne, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Gjedde, A., Ott, P. & Waagepetersen, Helle S., 2007, In: Neurochemistry International. 50, p. 1042-1051

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Yield and Integrity of RNA from Brain Samples are Largely Unaffected by Pre-analytical Procedures

    Jensen, P. S. H., Johansen, M., Bak, Lasse Kristoffer, Jensen, Lars Juhl & Kjær, C., 2021, In: Neurochemical Research. 46, p. 447-454

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism

    Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function

    Jakobsen, Emil, Lange, S. C. & Bak, Lasse Kristoffer, Aug 2019, In: Journal of Neuroscience Research. 97, 8, p. 1018-1038 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen

    Jakobsen, Emil, Andersen, Jens Velde, Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, Helle S., Aldana, Blanca & Bak, Lasse Kristoffer, 2021, In: Glia. 69, 12, p. 2828-2844 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1303653