Lasse Kristoffer Bak
Guest Researcher, Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
TG IV
Jagtvej 160
2100 København Ø
- 2014
- Published
Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization
Pajęcka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 2014, In: Neurochemical Research. 39, 3, p. 487-99 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate metabolism in the brain focusing on astrocytes
Schousboe, Arne, Scafidi, S., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & McKenna, M. C., 2014, In: Advances in Neurobiology. 11, p. 13-30 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans
Iversen, P., Mouridsen, K., Hansen, M. B., Jensen, S. B., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Ott, P., Vilstrup, H., Keiding, S. & Gjedde, Albert, 2014, In: Frontiers in Neuroscience. 8, p. 353Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic mapping of astrocytes and neurons in culture using stable isotopes and gas chromatography-mass spectrometry (GC-MS)
Walls, Anne Byriel, Bak, Lasse Kristoffer, Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Jan 2014, In: Neuromethods. 90, p. 73-105 33 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats
Fries, A. W., Dadsetan, S., Keiding, S., Bak, Lasse Kristoffer, Schousboe, Arne, Waagepetersen, Helle S., Simonsen, M., Ott, P., Vilstrup, H. & Sørensen, M., Mar 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 460-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro
Schousboe, Arne, Waagepetersen, Helle S., Leke, R. & Bak, Lasse Kristoffer, 1 Mar 2014, In: Metabolic Brain Disease. 29, 4, p. 913-917 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis
Müller, M. S., Fox, R., Schousboe, Arne, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes
Müller, M. S., Pedersen, Sofie E., Walls, Anne Byriel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Jan 2015, In: Glia. 63, 1, p. 154-62 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamine and ammonia in hepatic encephalopathy
Dadsetan, S., Waagepetersen, Helle S., Schousboe, Arne & Bak, Lasse Kristoffer, 1 Jan 2015, Glutamine in Clinical Nutrition. Springer New York LLC, p. 219-227 9 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The Glutamine-Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism
Walls, Anne Byriel, Waagepetersen, Helle S., Bak, Lasse Kristoffer, Schousboe, Arne & Sonnewald, U., Feb 2015, In: Neurochemical Research. 40, 2, p. 402-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?
Bak, Lasse Kristoffer, Mueller, M. S., Fox, R., Pedersen, Sofie E., Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Jakobsen, E., Schousboe, Arne & Waagepetersen, Helle S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Dynamic changes in cytosolic ATP levels in cultured glutamatergic neurons during NMDA-induced synaptic activity supported by glucose or lactate
Lange, S. C., Winkler, U., Andresen, Lars, Byhrø, M., Waagepetersen, Helle S., Hirrlinger, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2517-2526 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism
Satrústegui, J. & Bak, Lasse Kristoffer, Dec 2015, In: Neurochemical Research. 40, 12, p. 2425-30 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism
Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission
Walls, Anne Byriel, Flynn, S. P., West, P. J., Müller, M. S., Bak, Lasse Kristoffer, Bulaj, G., Schousboe, Arne & White, H. S., Mar 2016, In: Epilepsy Research. 121, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons
Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes
Nissen, J. D., Lykke, K., Bryk, J., Stridh, M. H., Zaganas, I., Jensen, Dorte Skytt, Schousboe, Arne, Bak, Lasse Kristoffer, Enard, W., Pääbo, S. & Waagepetersen, Helle S., 2017, In: Glia. 65, 3, p. 474–488Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals
Hohnholt, M. C., Andersen, V. H., Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 1, p. 191-201 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, , 2017, In: Stem Cell Reports. 8, 3, p. 648-658Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytes take the stage in a tale of signaling-metabolism coupling
Bak, Lasse Kristoffer, 2 Jun 2017, In: The Journal of Biological Chemistry. 292, 22, p. 9439-9440 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?
Bak, Lasse Kristoffer, Christiansen, Ann-Kathrin Lindahl, Kjaer, C., Jakobsen, Emil, Hedehus, J., Mertz, C., Madsen, S., Jensen, M., Bergstedt, N., Knezevic, A. & Lindholm, S., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes
Jakobsen, Emil, Madsen, S. F., Hedehus, J., Rubio-Villena, C., Jorgensen, N. H. & Bak, Lasse Kristoffer, Aug 2017, p. 147-147.Research output: Contribution to conference › Poster › Research
- Published
Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase
Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression
Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1303653
Most downloads
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461
downloads
Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
321
downloads
Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published -
195
downloads
Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes
Research output: Contribution to conference › Poster › Research
Published