Lasse Kristoffer Bak

Lasse Kristoffer Bak

Guest Researcher, Professor

ORCID: 0000-0003-0784-7864

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  1. Published

    Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons

    Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

    Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Compartmentalised signalling-metabolism coupling in brain cells - putative drug targets for neurological diseases?

    Bak, Lasse Kristoffer, Christiansen, Ann-Kathrin Lindahl, Kjaer, C., Jakobsen, Emil, Hedehus, J., Mertz, C., Madsen, S., Jensen, M., Bergstedt, N., Knezevic, A. & Lindholm, S., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  4. Published

    Two isoforms of glycogen phosphorylase activated by the same signaling trains: how and why?

    Bak, Lasse Kristoffer, Mueller, M. S., Fox, R., Pedersen, Sofie E., Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Jakobsen, E., Schousboe, Arne & Waagepetersen, Helle S., Aug 2015, In: Journal of Neurochemistry. 134, suppl. 1, p. 56-56 1 p., S26-01.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  5. Published

    CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

    Bak, Lasse Kristoffer & Walls, Anne Byriel, 1 Feb 2018, In: The Journal of Physiology. 596, 3, p. 351-353 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Astrocytic glycogen metabolism in the healthy and diseased brain

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  7. Published

    Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels

    Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Astrocytes take the stage in a tale of signaling-metabolism coupling

    Bak, Lasse Kristoffer, 2 Jun 2017, In: The Journal of Biological Chemistry. 292, 22, p. 9439-9440 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

    Bak, Lasse Kristoffer, Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Oct 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 10, p. 1285-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures

    Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

    Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, Jan 2004, In: Neurochemical Research. 29, 1, p. 257-65 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Rebuttal from Lasse K. Bak and Anne B. Walls

    Bak, Lasse Kristoffer & Walls, Anne Byriel, 1 Feb 2018, In: The Journal of Physiology. 596, 3, p. 357

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  16. Published

    Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

    Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  19. Published

    Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

    Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Planning and execution of a one-day PhD course employing the theory of didactical situations

    Bak, Lasse Kristoffer, 2010, Improving university science teaching and learning: pedagogical projects 2008. Voetmann Christiansen, F., Rump, C. & Degn, L. (eds.). Department of Science Education, University of Copenhagen, Vol. 1. p. 13-19 (Uden navn, Vol. 1).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  21. Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy

    Bak, Lasse Kristoffer, Waagepetersen, H. S., Sørensen, M., Ott, P., Vilstrup, H., Keiding, S. & Schousboe, A., Jun 2013, In: Metabolic Brain Disease. 28, 2, p. 209-15 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Glutamate and glutamine in brain disorders

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  25. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journal › Journal article › Research › peer-review

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