Matthias Manfred Herth
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
Herth, Matthias Manfred, Barz, M., Jahn, M., Zentel, R. & Rösch, F., 15 Sep 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5454-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Total synthesis and evaluation of [18F]MHMZ
Herth, Matthias Manfred, Debus, F., Piel, M., Palner, M., Knudsen, Gitte Moos, Lüddens, H. & Rösch, F., 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 4, p. 1515-1519 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands
Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Current radiosynthesis strategies for 5-HT2A receptor PET tracers
Herth, Matthias Manfred & Knudsen, G. M., 15 Jun 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 7, p. 265-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs
Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion
Herth, M. M., Ametamey, S., Antuganov, D., Bauman, A., Berndt, M., Brooks, A. F., Bormans, G., Choe, Y. S., Gillings, N., Hafeli, U. O., James, M. L., Kopka, K., Kramer, V., Krasikova, R., Madsen, J., Mu, L., Neumaier, B., Piel, M., Roesch, F., Ross, T. & 6 others, , 2021, In: Nuclear Medicine and Biology. 93, p. 19-21 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptor’s In Vivo Brain Function
Herth, Matthias Manfred & Knudsen, Gitte Moos, 2018, 5-HT2A Receptors in the Central Nervous System. Guiard, B. P. & Di Giovanni, G. (eds.). Humana Press, p. 85-134 (Receptors Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18 Sep Pak™ cartridge
Herth, Matthias Manfred, Thorpe, M. R. & Ferrieri, R. A., 1 Apr 2005, In: Journal of Labelled Compounds and Radiopharmaceuticals. 48, 5, p. 379-386 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET
Herth, Matthias Manfred, Kramer, V., Piel, M., Palner, M., Riss, P. J., Knudsen, Gitte Moos & Roesch, F., 2009, In: Bioorganic & Medicinal Chemistry. 17, 8, p. 2989-3002Research output: Contribution to journal › Journal article › Research › peer-review
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Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography
Herth, Matthias Manfred, Barz, M., Moderegger, D., Allmeroth, M., Jahn, M., Thews, O., Zentel, R. & Rösch, F., 13 Jul 2009, In: Biomacromolecules. 10, 7, p. 1697-703 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes
Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [F-18]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging
Herth, Matthias Manfred, Kramer, V. & Roesch, F., 15 May 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 5-6, p. 201-207Research output: Contribution to journal › Journal article › Research › peer-review
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Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor
Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.Research output: Contribution to conference › Conference abstract for conference › Research
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Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET
Herth, Matthias Manfred, Kramer, V., Gillings, N., Roesch, F. & Knudsen, G. M., Jul 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354-358Research output: Contribution to journal › Journal article › Research › peer-review
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Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [F-18]MH.MZ
Herth, Matthias Manfred, Piel, M., Debus, F., Schmitt, U., Lueddens, H. & Roesch, F., May 2009, In: Nuclear Medicine and Biology. 36, 4, p. 447-454Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET
Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007Research output: Contribution to journal › Journal article › Research › peer-review
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Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging
Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277Research output: Contribution to journal › Journal article › Research › peer-review
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Preliminary Evaluation of (S)-7-[F-18]Fluorotryptophan as a Tracer for the Imaging of Tryptophan Metabolism Alterations in Tumor Xenografts
Hvass, L., Shalgunov, Vladimir, Jorgensen, J. T., Zlatopolskiy, B. D., Neumaier, B., Kjær, Andreas & Herth, Matthias Manfred, 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, SUPPL 1, p. S646-S647 Meeting Abstract: EP-282 .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography
Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, Matthias Manfred, Kristensen, Jesper Langgaard, Palner, M. & Janfelt, Christian, 2021, In: Molecular Imaging and Biology. 23, p. 676–685Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites
Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.Research output: Contribution to journal › Letter › Research › peer-review
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Optimization and Evaluation of Al18F Labeling Using a NOTA—or RESCA1-Conjugated AE105 Peptide Antagonist of uPAR
Jeppesen, T. E., Simón, M., Torp, J., Knudsen, Line Bruhn Schneider, Leth, Julie Maja, Crestey, F., Ploug, Michael, Jørgensen, Jesper Tranekjær, Madsen, J., Herth, Matthias Manfred & Kjær, Andreas, 2021, In: Frontiers in Nuclear Medicine. 1, 9 p., 799533.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantification accuracy of a new HRRT high throughput rat hotel using transmission-based attenuation correction: A phantom study
Keller, S. H., L'Estrade, E. N., Dall, B., Palner, M. & Herth, Matthias Manfred, 16 Oct 2017.Research output: Contribution to conference › Paper › Research › peer-review
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The polypharmacological profile of psilocybin and potential behavioural effects of very low doses
Kiilerich, K., Speth, N., Lorenz, J., Casado-Sainz, A., Shalgunov, Vladimir, Lange, D., Xiong, M., Herth, Matthias Manfred, Overgaard, A., Hansen, H. D. & Palner, M., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S175-S176 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Kiilerich, K. F., Lorenz, J., Scharff, M. B., Speth, N., Brandt, T. G., Czurylo, J., Xiong, M., Jessen, N. S., Casado-Sainz, A., Shalgunov, Vladimir, Kjærby, Celia, Satała, G., Bojarski, A. J., Jensen, Anders A., Herth, Matthias Manfred, Cumming, P., Overgaard, A. & Palner, M., 2023, In: Molecular Psychiatry. 28, 9, p. 3829-3841Research output: Contribution to journal › Journal article › Research › peer-review
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The Center for Integrated Molecular Brain Imaging (Cimbi) database
Knudsen, G. M., Jensen, P. S., Erritzoe, D., Baaré, W. F. C., Ettrup, A., Fisher, P. M., Gillings, N., Hansen, H. D., Hansen, L. K., Hasselbalch, S. G., Henningsson, S., Herth, M. M., Holst, K. K., Iversen, P., Kessing, L. V., Macoveanu, J., Madsen, K. S., Mortensen, E. L., Nielsen, F. Å., Paulson, O. B. & 6 others, , 17 Apr 2015, In: NeuroImage. 124 , Part B, p. 1213-19 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alpha-Synuclein PET tracer development-an overview about current efforts
Korat, Š., Bidesi, N. S. R., Bonanno, F., Di Nanni, A., Hoàng, A. N. N., Herfert, K., Maurer, A., Battisti, Umberto Maria, Bowden, G. D., Thonon, D., Vugts, D., Windhorst, A. D. & Herth, Matthias Manfred, 2021, In: Pharmaceuticals. 14, 9, 45 p., 847.Research output: Contribution to journal › Review › Research › peer-review
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Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals
Korde, A., Mikolajczak, R., Kolenc, P., Bouziotis, P., Westin, H., Lauritzen, M., Koole, M., Herth, Matthias Manfred, Bardiès, M., Martins, A. F., Paulo, A., Lyashchenko, S. K., Todde, S., Nag, S., Lamprou, E., Abrunhosa, A., Giammarile, F. & Decristoforo, C., 2022, In: EJNMMI Radiopharmacy and Chemistry. 7, 1, 18.Research output: Contribution to journal › Review › Research › peer-review
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Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode
Kramer, V., Herth, Matthias Manfred, Santini, M. A., Palner, M., Knudsen, Gitte Moos & Rösch, F., 1 Oct 2010, In: Chemical Biology & Drug Design (Online). 76, 4, p. 361-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain
Kramer, V., Dyssegaard, A., Flores, J., Soza-Ried, C., Rösch, F., Knudsen, Gitte Moos, Amaral, H. & Herth, Matthias Manfred, 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, p. 355-365Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Textbook of Drug Design and Discovery: In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Novel, Versatile Three-Step Synthesis of 1,2,3,4,10,10a-Hexahydropyrazino[1,2-a]indoles by Intramolecular Carbene-Mediated C-H Insertion
Krogsgaard-Larsen, N., Begtrup, M., Herth, Matthias Manfred & Kehler, J., Dec 2010, In: Synthesis. 24, p. 4287-4299Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors
L 'Estrade, E. T., Shalgunov, Vladimir, Edgar, F. G., Strebl-Bantillo, M. G., Xiong, M., Crestey, F., Neelamegam, R., Dyssegaard, A., Lehel, S., Erlandsson, M., Ohlsson, T., Hooker, J. M., Knudsen, Gitte Moos, Herth, Matthias Manfred & Hansen, H. D., 2020, In: Journal of Labelled Compounds and Radiopharmaceuticals. 63, p. 46-55Research output: Contribution to journal › Journal article › Research › peer-review
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Towards selective CNS PET Imaging of the 5-HT7 Receptor System: Past, Present and Future
L'Estrade, E. T., Erlandsson, M., Edgar, F. G., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 2020, In: Neuropharmacology. 172, 107830.Research output: Contribution to journal › Review › Research › peer-review
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Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors
L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851Research output: Contribution to journal › Journal article › Research › peer-review
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PET radiotracer translation from rats to higher species, using an increased-throughput in vivo evaluation strategy
L'Estrade, E. T., Xiong, M., Petersen, I., Shalgunov, Vladimir, Edgar, F. G., Hansen, H., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Palner, M. & Herth, Matthias Manfred, May 2019, p. S389-S390.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor
Lacivita, E., Niso, M., Hansen, H. D., Di Pilato, P., Herth, Matthias Manfred, Lehel, S., Ettrup, A., Montenegro, L., Perrone, R., Berardi, F., Colabufo, N. A., Leopoldo, M. & Knudsen, G. M., 1 Mar 2014, In: Bioorganic & Medicinal Chemistry. 22, 5, p. 1736-1750 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-throughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride
Lange, D., Tejada, I. M., Xiong, M., Hillebrand, B., Noergaard, M., Baerentzen, S., Shalgunov, Vladimir, Herth, Matthias Manfred, Svarer, C. & Palner, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 588-589 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Selective O-[C-11]methylation of 1-(3-hydroxyphenyl)piperazine
Lehel, S., Herth, Matthias Manfred, Andersen, V. L., Gillings, N. & Madsen, J., 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S334-S334Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Development and evaluation of an 18F-labeled nanobody to target SARS-CoV-2's spike protein
Lopes van den Broek, S., García-Vázquez, R., Andersen, Ida Vang, Valenzuela-Nieto, G., Shalgunov, Vladimir, Battisti, Umberto Maria, Schwefel, D., Modhiran, N., Kramer, V., Cheuquemilla, Y., Jara, R., Salinas-Varas, C., Amarilla, A. A., Watterson, D., Rojas-Fernandez, A. & Herth, Matthias Manfred, 2022, In: Frontiers in Nuclear Medicine. 2, 1033697.Research output: Contribution to journal › Journal article › Research › peer-review
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Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?
Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.Research output: Contribution to journal › Journal article › Research › peer-review
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The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor
L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In: Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A facile synthesis of precursor for the σ-1 receptor PET radioligand [18F]FTC-146 and its radiofluorination
Marešová, A., Jurášek, M., Drašar, P. B., Dolenský, B., Prokudina, E. A., Shalgunov, Vladimir, Herth, Matthias Manfred, Cumming, P. & Popkov, A., 2024, In: Journal of Labelled Compounds and Radiopharmaceuticals. 67, 2, p. 59-66Research output: Contribution to journal › Journal article › Research › peer-review
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Three weeks of daily exposure to bright light does not alter striatal serotonin transporter binding in healthy Scandinavians
Mc Mahon, B., Andersen, A. S., Feng, L., Madsen, M. K., Lehel, S., Herth, Matthias Manfred, Iversen, P., Hasholt, Lis Frydenreich & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S79-S80Research output: Contribution to journal › Journal article › Research › peer-review
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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
Modhiran, N., Lauer, S. M., Amarilla, A. A., Hewins, P., Lopes van den Broek, S. I., Low, Y. S., Thakur, N., Liang, B., Nieto, G. V., Jung, J., Paramitha, D., Isaacs, A., Sng, J. D. J., Song, D., Jørgensen, J. T., Cheuquemilla, Y., Bürger, J., Andersen, I. V., Himelreichs, J., Jara, R. & 18 others, , 2023, In: iScience. 26, 7, 26 p., 107085.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, radiofluorination and first evaluation of (+/-)-[F-18]MDL 100907 as serotonin 5-HT2A receptor antagonist for PET
Muehlhausen, U., Ermert, J., Herth, Matthias Manfred & Coenen, H. H., 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 1-2, p. 6-12Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and in vivo evaluation of [11C]tucatinib for HER2-targeted PET imaging
Müller, Marius, Shalgunov, Vladimir, Hvass, Lars, Jørgensen, Jesper Tranekjær, Kramer, V., Staudt, Markus, Battisti, Umberto Maria, Kjær, Andreas & Herth, Matthias Manfred, 2023, In: Bioorganic and Medicinal Chemistry Letters. 80, 5 p., 129088.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33147568
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
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Convenient access to F-18-labeled amines through the Staudinger reduction
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363
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Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
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