Matthias Manfred Herth

Matthias Manfred Herth

Professor


Publication year:
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101 - 146 out of 146Page size: 50
  1. 2017
  2. Published

    Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

    Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  3. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices

    Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Textbook of Drug Design and Discovery: In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  5. 2016
  6. Published

    In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  7. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    In Vivo Radionuclide Generators for Diagnostics and Therapy

    Edem, P. E., Fonslet, J., Kjær, Andreas, Herth, Matthias Manfred & Severin, G., 2016, In: Bioinorganic Chemistry and Applications. 2016, p. 1-9 9 p., 6148357.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2015
  11. Published

    Current radiosynthesis strategies for 5-HT2A receptor PET tracers

    Herth, Matthias Manfred & Knudsen, G. M., 15 Jun 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 7, p. 265-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36

    Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  13. Published

    Selective O-[C-11]methylation of 1-(3-hydroxyphenyl)piperazine

    Lehel, S., Herth, Matthias Manfred, Andersen, V. L., Gillings, N. & Madsen, J., 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S334-S334

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  14. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The Center for Integrated Molecular Brain Imaging (Cimbi) database

    Knudsen, G. M., Jensen, P. S., Erritzoe, D., Baaré, W. F. C., Ettrup, A., Fisher, P. M., Gillings, N., Hansen, H. D., Hansen, L. K., Hasselbalch, S. G., Henningsson, S., Herth, M. M., Holst, K. K., Iversen, P., Kessing, L. V., Macoveanu, J., Madsen, K. S., Mortensen, E. L., Nielsen, F. Å., Paulson, O. B. & 6 others, Siebner, Hartwig Roman, Stenbæk, D. S., Svarer, C., Jernigan, T. L., Strother, S. C. & Frøkjær, Vibe Gedsø, 17 Apr 2015, In: NeuroImage. 124 , Part B, p. 1213-19 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs

    Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2014
  19. Published

    Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

    Hansen, H. D., Lacivita, E., Di Pilato, P., Herth, Matthias Manfred, Lehel, S., Ettrup, A., Andersen, V. L., Dyssegaard, A., De Giorgio, P., Perrone, R., Berardi, F., Colabufo, N. A., Niso, M., Knudsen, G. M. & Leopoldo, M., 22 May 2014, In: European Journal of Medicinal Chemistry. 79, p. 152-163 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor

    Lacivita, E., Niso, M., Hansen, H. D., Di Pilato, P., Herth, Matthias Manfred, Lehel, S., Ettrup, A., Montenegro, L., Perrone, R., Berardi, F., Colabufo, N. A., Leopoldo, M. & Knudsen, G. M., 1 Mar 2014, In: Bioorganic & Medicinal Chemistry. 22, 5, p. 1736-1750 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

    Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2013
  25. Published

    Comparison of the 5-HT2A PET tracers, [F-18]MH.MZ and [F-18]altanserin

    Hansen, H., Herth, Matthias Manfred, Ettrup, A., Dyssegaard, A. & Knudsen, Gitte Moos, May 2013, p. S338-S338.

    Research output: Contribution to conference › Conference abstract for conference › Research

  26. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor

    Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.

    Research output: Contribution to conference › Conference abstract for conference › Research

  27. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conference › Conference abstract for conference › Research

  28. Published

    Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

    Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Direct comparison of [18F]MH.MZ and [18F]altanserin for 5-HT2A receptor imaging with PET

    Hansen, H. D., Ettrup, A., Herth, Matthias Manfred, Dyssegaard, A., Ratner, C., Gillings, N. & Knudsen, G. M., 2013, In: Synapse. 67, 6, p. 328-337 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

    Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2012
  32. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Development of an F-18-labelled 5-HT2A receptor agonist PET radioligand

    Ettrup, A., Hansen, M., Gillings, N., Dyssegaard, A., Lehel, S., Hansen, H. D., Herth, Matthias Manfred, Madsen, J., Kristensen, J. & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S109-S109

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Three weeks of daily exposure to bright light does not alter striatal serotonin transporter binding in healthy Scandinavians

    Mc Mahon, B., Andersen, A. S., Feng, L., Madsen, M. K., Lehel, S., Herth, Matthias Manfred, Iversen, P., Hasholt, Lis Frydenreich & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S79-S80

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET

    Herth, Matthias Manfred, Kramer, V., Gillings, N., Roesch, F. & Knudsen, G. M., Jul 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354-358

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2011
  39. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging

    Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    P-Glycoprotein Influence on the Brain Uptake of a 5-HT2A Ligand: [F-18]MH.MZ

    Schmitt, U., Leed, D. E., Herth, Matthias Manfred, Piel, M., Buchholz, H., Roesch, F., Hiemke, C., Lueddens, H. & Debus, F., 2011, In: Neuropsychobiology. 63, 3, p. 183-190

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2010
  43. Published

    Novel, Versatile Three-Step Synthesis of 1,2,3,4,10,10a-Hexahydropyrazino[1,2-a]indoles by Intramolecular Carbene-Mediated C-H Insertion

    Krogsgaard-Larsen, N., Begtrup, M., Herth, Matthias Manfred & Kehler, J., Dec 2010, In: Synthesis. 24, p. 4287-4299

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode

    Kramer, V., Herth, Matthias Manfred, Santini, M. A., Palner, M., Knudsen, Gitte Moos & Rösch, F., 1 Oct 2010, In: Chemical Biology & Drug Design (Online). 76, 4, p. 361-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

    Herth, Matthias Manfred, Barz, M., Jahn, M., Zentel, R. & Rösch, F., 15 Sep 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5454-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging

    Debus, F., Herth, Matthias Manfred, Piel, M., Buchholz, H., Bausbacher, N., Kramer, V., Lüddens, H. & Rösch, F., May 2010, In: Nuclear Medicine and Biology. 37, 4, p. 487-95 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2009
  48. Published

    Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography

    Herth, Matthias Manfred, Barz, M., Moderegger, D., Allmeroth, M., Jahn, M., Thews, O., Zentel, R. & Rösch, F., 13 Jul 2009, In: Biomacromolecules. 10, 7, p. 1697-703 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [F-18]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging

    Herth, Matthias Manfred, Kramer, V. & Roesch, F., 15 May 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 5-6, p. 201-207

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [F-18]MH.MZ

    Herth, Matthias Manfred, Piel, M., Debus, F., Schmitt, U., Lueddens, H. & Roesch, F., May 2009, In: Nuclear Medicine and Biology. 36, 4, p. 447-454

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET

    Herth, Matthias Manfred, Kramer, V., Piel, M., Palner, M., Riss, P. J., Knudsen, Gitte Moos & Roesch, F., 2009, In: Bioorganic & Medicinal Chemistry. 17, 8, p. 2989-3002

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Synthesis, radiofluorination and first evaluation of (+/-)-[F-18]MDL 100907 as serotonin 5-HT2A receptor antagonist for PET

    Muehlhausen, U., Ermert, J., Herth, Matthias Manfred & Coenen, H. H., 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 1-2, p. 6-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2008
  54. Published

    Total synthesis and evaluation of [18F]MHMZ

    Herth, Matthias Manfred, Debus, F., Piel, M., Palner, M., Knudsen, Gitte Moos, Lüddens, H. & Rösch, F., 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 4, p. 1515-1519 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2007
  56. Published

    11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled

    Thorpe, M. R., Ferrieri, A. P., Herth, Matthias Manfred & Ferrieri, R. A., Jul 2007, In: Planta. 226, 2, p. 541-51 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. 2005
  58. Published

    Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18 Sep Pak™ cartridge

    Herth, Matthias Manfred, Thorpe, M. R. & Ferrieri, R. A., 1 Apr 2005, In: Journal of Labelled Compounds and Radiopharmaceuticals. 48, 5, p. 379-386 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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