Matthias Manfred Herth

Matthias Manfred Herth

Professor


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  1. Published

    Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor

    L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In: Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta-particle emitter, 177Lu

    Shalgunov, Vladimir, Engudar, G., Bohrmann, L., Wharton, L., Maskell, K., Johann, K., Barz, M., Schaffer, P., Herth, Matthias Manfred & Radchenko, V., 2022, In: Nuclear Medicine and Biology. 104-105, p. 11-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Radiolabelling and Evaluation of a Sc-44-labelled DOTA Tetrazine for Pretargeted PET Imaging

    Edem, P., Sinnes, J., Pektor, S., Bausbacher, N., Rossin, R., Abdoireza, Y., Kjær, Andreas, Valliant, J., Robillard, M., Roesch, F. & Herth, Matthias Manfred, 1 May 2018. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  4. Published

    Radionuclide Imaging for Neuroscience: Current Opinion and Future Directions

    Gee, A. D., Herth, Matthias Manfred, James, M. L., Korde, A., Scott, P. J. H. & Vasdev, N., 2020, In: Molecular Imaging. 19, 9 p., 1536012120936397.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

    Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  6. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

    L 'Estrade, E. T., Shalgunov, Vladimir, Edgar, F. G., Strebl-Bantillo, M. G., Xiong, M., Crestey, F., Neelamegam, R., Dyssegaard, A., Lehel, S., Erlandsson, M., Ohlsson, T., Hooker, J. M., Knudsen, Gitte Moos, Herth, Matthias Manfred & Hansen, H. D., 2020, In: Journal of Labelled Compounds and Radiopharmaceuticals. 63, p. 46-55

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging

    García-Vázquez, R., Battisti, Umberto Maria & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 6, 25 p., 685.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats

    Kiilerich, K. F., Lorenz, J., Scharff, M. B., Speth, N., Brandt, T. G., Czurylo, J., Xiong, M., Jessen, N. S., Casado-Sainz, A., Shalgunov, Vladimir, Kjærby, Celia, Satała, G., Bojarski, A. J., Jensen, Anders A., Herth, Matthias Manfred, Cumming, P., Overgaard, A. & Palner, M., 2023, In: Molecular Psychiatry. 28, 9, p. 3829-3841

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain

    Shalgunov, Vladimir, Lilius, T., Sigurosson, B., Baerentzen, S. L., Hauglund, Natalie Linea, Herth, Matthias Manfred, Palner, M. & Nedergaard, Maiken, 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supplement 1, p. S404-S405 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  12. Published

    Selective O-[C-11]methylation of 1-(3-hydroxyphenyl)piperazine

    Lehel, S., Herth, Matthias Manfred, Andersen, V. L., Gillings, N. & Madsen, J., 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S334-S334

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  13. Published

    Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode

    Kramer, V., Herth, Matthias Manfred, Santini, M. A., Palner, M., Knudsen, Gitte Moos & Rösch, F., 1 Oct 2010, In: Chemical Biology & Drug Design (Online). 76, 4, p. 361-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy

    Sporer, E., Poulie, Christian Bernard Matthijs, Lindegren, S., Aneheim, E., Jensen, H., Bäck, T., Kempen, Paul Joseph, Kjær, Andreas, Herth, Matthias Manfred & Jensen, A. I., 2021, In: Journal of Nanotheranostics. 2, 4, p. 196-207

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

    Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, Ida Vang, Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, Jens D., Fisher, P. M. D., Herth, Matthias Manfred, Plavén-Sigray, P., Knudsen, Gitte Moos & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Synergistic Experimental and Computational Investigation of the Bioorthogonal Reactivity of Substituted Aryltetrazines

    Battisti, Umberto Maria, García-Vázquez, R., Svatunek, D., Herrmann, B., Löffler, A., Mikula, H. & Herth, Matthias Manfred, 2022, In: Bioconjugate Chemistry. 33, 4, p. 608-624

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors

    L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conference › Conference abstract for conference › Research

  22. Published

    Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

    Schlein, E., Rokka, J., Odell, L. R., van den Broek, S. L., Herth, Matthias Manfred, Battisti, Umberto Maria, Syvänen, S., Sehlin, D. & Eriksson, J., 2024, In: EJNMMI Radiopharmacy and Chemistry. 9, 1, 12 p., 21.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET

    Herth, Matthias Manfred, Kramer, V., Piel, M., Palner, M., Riss, P. J., Knudsen, Gitte Moos & Roesch, F., 2009, In: Bioorganic & Medicinal Chemistry. 17, 8, p. 2989-3002

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synthesis and in vivo evaluation of [11C]tucatinib for HER2-targeted PET imaging

    Müller, Marius, Shalgunov, Vladimir, Hvass, Lars, Jørgensen, Jesper Tranekjær, Kramer, V., Staudt, Markus, Battisti, Umberto Maria, Kjær, Andreas & Herth, Matthias Manfred, 2023, In: Bioorganic and Medicinal Chemistry Letters. 80, 5 p., 129088.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synthesis and radiolabeling of a polar [125 I]I-1,2,4,5-tetrazine

    Bidesi, N., Shalgunov, Vladimir, Battisti, Umberto Maria, Hvass, Lars, Jørgensen, Jesper Tranekjær, Poulie, Christian Bernard Matthijs, Jensen, A. I., Kjær, Andreas & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 1, p. 22-30

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [F-18]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging

    Herth, Matthias Manfred, Kramer, V. & Roesch, F., 15 May 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 5-6, p. 201-207

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18 Sep Pak™ cartridge

    Herth, Matthias Manfred, Thorpe, M. R. & Ferrieri, R. A., 1 Apr 2005, In: Journal of Labelled Compounds and Radiopharmaceuticals. 48, 5, p. 379-386 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [18F]ENL30: A Potential PET Radiotracer for the 5-HT7 Receptor

    Tampio L'Estrade, E., Edgar, F. G., Xiong, M., Shalgunov, Vladimir, Baerentzen, S. L., Erlandsson, M., Ohlsson, T. G., Palner, M., Knudsen, Gitte Moos & Herth, Matthias Manfred, 23 Apr 2019, In: ACS Omega. 4, 4, p. 7344-7353

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Synthesis, radiofluorination and first evaluation of (+/-)-[F-18]MDL 100907 as serotonin 5-HT2A receptor antagonist for PET

    Muehlhausen, U., Ermert, J., Herth, Matthias Manfred & Coenen, H. H., 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 1-2, p. 6-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150

    Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Herth, Matthias Manfred, Oct 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

    Hansen, H. D., Lacivita, E., Di Pilato, P., Herth, Matthias Manfred, Lehel, S., Ettrup, A., Andersen, V. L., Dyssegaard, A., De Giorgio, P., Perrone, R., Berardi, F., Colabufo, N. A., Niso, M., Knudsen, G. M. & Leopoldo, M., 22 May 2014, In: European Journal of Medicinal Chemistry. 79, p. 152-163 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Textbook of Drug Design and Discovery: In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  33. Published

    The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

    Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    The Center for Integrated Molecular Brain Imaging (Cimbi) database

    Knudsen, G. M., Jensen, P. S., Erritzoe, D., Baaré, W. F. C., Ettrup, A., Fisher, P. M., Gillings, N., Hansen, H. D., Hansen, L. K., Hasselbalch, S. G., Henningsson, S., Herth, M. M., Holst, K. K., Iversen, P., Kessing, L. V., Macoveanu, J., Madsen, K. S., Mortensen, E. L., Nielsen, F. Å., Paulson, O. B. & 6 others, Siebner, Hartwig Roman, Stenbæk, D. S., Svarer, C., Jernigan, T. L., Strother, S. C. & Frøkjær, Vibe Gedsø, 17 Apr 2015, In: NeuroImage. 124 , Part B, p. 1213-19 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

    Bærentzen, S., Casado-Sainz, A., Lange, D., Shalgunov, Vladimir, Tejada, I. M., Xiong, M., L'Estrade, E. T., Edgar, F. G., Lee, H., Herth, Matthias Manfred & Palner, M., 2019, In: Frontiers in Neuroscience. 13, 7 p., 187.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β

    Di Nanni, A., Saw, R. S., Bowden, G. D., Bidesi, N. S. R., Bjerregaard-Andersen, K., Korat, Š., Herth, Matthias Manfred, Pichler, B. J., Herfert, K. & Maurer, A., 2023, In: Molecules. 28, 10, 20 p., 4001.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The polypharmacological profile of psilocybin and potential behavioural effects of very low doses

    Kiilerich, K., Speth, N., Lorenz, J., Casado-Sainz, A., Shalgunov, Vladimir, Lange, D., Xiong, M., Herth, Matthias Manfred, Overgaard, A., Hansen, H. D. & Palner, M., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S175-S176 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  38. Published

    The role of neuroimaging in Parkinson’s disease

    Bidesi, N. S. R., Andersen, Ida Vang, Windhorst, A. D., Shalgunov, Vladimir & Herth, Matthias Manfred, 2021, In: Journal of Neurochemistry. 159, 4, p. 660-689

    Research output: Contribution to journal › Review › Research › peer-review

  39. Published

    Three weeks of daily exposure to bright light does not alter striatal serotonin transporter binding in healthy Scandinavians

    Mc Mahon, B., Andersen, A. S., Feng, L., Madsen, M. K., Lehel, S., Herth, Matthias Manfred, Iversen, P., Hasholt, Lis Frydenreich & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S79-S80

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Total synthesis and evaluation of [18F]MHMZ

    Herth, Matthias Manfred, Debus, F., Piel, M., Palner, M., Knudsen, Gitte Moos, Lüddens, H. & Rösch, F., 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 4, p. 1515-1519 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Towards selective CNS PET Imaging of the 5-HT7 Receptor System: Past, Present and Future

    L'Estrade, E. T., Erlandsson, M., Edgar, F. G., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 2020, In: Neuropharmacology. 172, 107830.

    Research output: Contribution to journal › Review › Research › peer-review

  42. Published

    Towards the Dual Click F-18-labeling of Antibodies

    Steen, J., Denk, C., Norregaard, K., Jorgensen, J., Rossin, R., Svatunek, D., Edem, P., Robillard, M., Kjær, Andreas, Kristensen, Jesper Langgaard, Mikula, H. & Herth, Matthias Manfred, 1 May 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  43. Published

    Training the next generation of radiopharmaceutical scientists

    Gee, A. D., Andersson, J., Bhalla, R., Choe, Y. S., Dick, D. W., Herth, M. M., Hostetler, E. D., Jauregui-Haza, U. J., Huang, Y-Y., James, M. L., Jeong, J. M., Korde, A., Kuge, Y., Kung, H. F., Lapi, S. E., Osso, J. A., Parent, E., Patt, M., Pricile, E. F., Riss, P. J. & 8 others, Santos-Oliveira, R., Taylor, S., Vasdev, N., Vercouillie, J., Wadsak, W., Yang, Z., Zhu, H. & Scott, P. J. H., 2020, In: Nuclear Medicine and Biology. 88-89, p. 10-13 4 p.

    Research output: Contribution to journal › Editorial › Research

  44. Published

    Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

    Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Johann, K., Norregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, Vladimir, Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, Jesper Langgaard, Mikula, H., Barz, M., Kjær, Andreas & Herth, Matthias Manfred, 2020, In: ACS Nano. 14, 1, p. 568-584

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging: [Meeting Abstract]

    Steen, J., Norregard, K., Johann, K., Jørgensen, Jesper Tranekjær, Svatunek, D., Birke, A., Edem, P., Rossin, R., Seidl, C., Schmid, F., Robillard, M., Mikula, H., Kristensen, Jesper Langgaard, Barz, M., Kjær, Andreas & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S109-S110

    Research output: Contribution to journal › Conference abstract in journal › Research

  46. Published

    Transport of nanomedicines across the blood-brain barrier: Challenges and opportunities for imaging and therapy

    van den Broek, S. L., Shalgunov, Vladimir & Herth, Matthias Manfred, 2022, In: Biomaterials Advances. 141, 11 p., 213125.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    [11C]Carboxylated Tetrazines for Facile Labeling of Trans-Cyclooctene-Functionalized PeptoBrushes

    García-Vázquez, R., Battisti, Umberto Maria, Shalgunov, Vladimir, Schäfer, G., Barz, M. & Herth, Matthias Manfred, 2022, In: Macromolecular Rapid Communications. 43, 12, 7 p., 2100655.

    Research output: Contribution to journal › Journal article › Research › peer-review

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