Sara Marie Øie Solbak
Assistant Professor
Structural Biology
Universitetsparken 2
2100 København Ø
- 2023
- Published
Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells
Zimmermann, J., van Haren, S. D., Arce, J., Adriawan, I. R., Wørzner, K., Krog, R. T., Guleed, S., Hu, T., Mortensen, R., Dietrich, J., Solbak, Sara Marie Øie, Levy, O., Christensen, D. & Pedersen, Gabriel Kristian, 2023, In: npj Vaccines. 8, 1, 12 p., 189.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the NCS-382 Scaffold for CaMKII alpha Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII alpha Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Veronesi, C., Hamborg, L., Thiesen, L., Bruus-Jensen, J., Royssen, J. S., Leurs, U., Larsen, A. S. G., Krall, J., Solbak, Sara Marie Øie, Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15066–15084Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds
Pallesen, J. S., Narayanan, Dilip, Tran, K. T., Solbak, Sara Marie Øie, Marseglia, G., Sørensen, L. M. E., Høj, L. J., Munafò, F., Carmona, R. M. C., Garcia, A. D., Desu, H. L., Brambilla, R., Johansen, Tommy Nørskov, Popowicz, G. M., Sattler, M., Gajhede, Michael & Bach, Anders, 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4623–4661Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel fragments binding to the PDZ1-2 domain of PSD-95
Zang, J., Ye, F., Solbak, Sara Marie Øie, Høj, L. J., Zhang, M. & Bach, Anders, 2021, In: ChemMedChem. 16, 6, p. 949-954Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
Fuchs, P. O., Calitz, C., Pavlovic, N., Binet, F., Solbak, Sara Marie Øie, Danielson, U. H., Kreuger, J., Heindryckx, F. & Gerwins, P., Aug 2020, In: Cellular Signalling. 72, 12 p., 109661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dynamics of linear polyubiquitin
Jussupow, A., Messias, A. C., Stehle, R., Geerlof, A., Solbak, Sara Marie Øie, Paissoni, C., Bach, Anders, Sattler, M. & Camilloni, C., Oct 2020, In: Science Advances. 6, 42, 13 p., eabc3786.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery
Solbak, Sara Marie Øie, Zang, J., Narayanan, Dilip, Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, Annette Eva, Gotfredsen, C. H., Sattler, M. & Bach, Anders, 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Molecular architecture of the Jumonji C family histone demethylase KDM5B
Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
Tran, K. T., Pallesen, J. S., Solbak, Sara Marie Øie, Narayanan, Dilip, Baig, A., Zang, J., Aguayo-Orozco, A., Carmona, R., Garcia, A. & Bach, Anders, 2019, In: Journal of Medicinal Chemistry. 62, 17, p. 8028-8052Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase.
Abdurakhmanov, E., Solbak, Sara Marie Øie & Danielson, U., Jun 2017, In: Viruses.Research output: Contribution to journal › Journal article › Research › peer-review
Insights from engineering the Affibody-Fc interaction with a computational-experimental method.
Nosrati, M., Solbak, Sara Marie Øie, Nordesjö, O., Nissbeck, M., Dourado, D., Andersson, K., Housaindokht, M., Löfblom, J., Virtanen, A., Danielson, U. & Flores, S., Sep 2017, In: Protein engineering, design & selection : PEDS.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.
Solbak, Sara Marie Øie, Abdurakhmanov, E., Vedeler, A. & Danielson, U., Dec 2017, In: Virology Journal.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.
Hahn, F., Setz, C., Friedrich, M., Rauch, P., Solbak, Sara Marie Øie, Frøystein, N., Henklein, P., Votteler, J., Fossen, T. & Schubert, U., Oct 2014, In: Viruses.Research output: Contribution to journal › Journal article › Research › peer-review
Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination.
Pedersen, G., Höschler, K., Solbak, Sara Marie Øie, Bredholt, G., Pathirana, R., Afsar, A., Breakwell, L., Nøstbakken, J., Raae, A., Brokstad, K., Sjursen, H., Zambon, M. & Cox, R., Jul 2014, In: Vaccine.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.
Solbak, Sara Marie Øie, Reksten, T., Hahn, F., Wray, V., Henklein, P., Henklein, P., Halskau, Ø., Schubert, U. & Fossen, T., Feb 2013, In: Biochimica et biophysica acta.Research output: Contribution to journal › Journal article › Research › peer-review
Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.
Solbak, Sara Marie Øie, Sharma, A., Bruns, K., Röder, R., Mitzner, D., Hahn, F., Niebert, R., Vedeler, A., Henklein, P., Henklein, P., Schubert, U., Wray, V. & Fossen, T., Feb 2013, In: Biochimica et biophysica acta.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
HIV-1 p6-Another viral interaction partner to the host cellular protein cyclophilin A.
Solbak, Sara Marie Øie, Reksten, T., Röder, R., Wray, V., Horvli, O., Raae, A., Henklein, P., Henklein, P. & Fossen, T., Apr 2012, In: Biochimica et biophysica acta.Research output: Contribution to journal › Journal article › Research › peer-review
Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding.
Webel, R., Solbak, Sara Marie Øie, Held, C., Milbradt, J., Groß, A., Eichler, J., Wittenberg, T., Jardin, C., Sticht, H., Fossen, T. & Marschall, M., Aug 2012, In: The Journal of general virology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.
Solbak, Sara Marie Øie, Wray, V., Horvli, O., Raae, A., Flydal, M., Henklein, P., Henklein, P., Nimtz, M., Schubert, U. & Fossen, T., 2011, In: BMC Structural Biology.Research output: Contribution to journal › Journal article › Research › peer-review
Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly.
Votteler, J., Neumann, L., Hahn, S., Hahn, F., Rauch, P., Schmidt, K., Studtrucker, N., Solbak, Sara Marie Øie, Fossen, T., Henklein, P., Ott, D., Holland, G., Bannert, N. & Schubert, U., 2011, In: Retrovirology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.
Solbak, Sara Marie Øie, Reksten, T., Wray, V., Bruns, K., Horvli, O., Raae, A., Henklein, P., Henklein, P., Röder, R., Mitzner, D., Schubert, U. & Fossen, T., 2010, In: BMC Structural Biology.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 157688952
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165
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Molecular architecture of the Jumonji C family histone demethylase KDM5B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
72
downloads
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
24
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The dynamics of linear polyubiquitin
Research output: Contribution to journal › Journal article › Research › peer-review
Published