Søren Brøgger Christensen
Professor emeritus, Professor, emeritus
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Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump
Mahmmoud, Y. A. & Christensen, Søren Brøgger, Oct 2011, In: BBA General Subjects. 1808, 10, p. 2413-2420Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of thapsigargin in isolated rat thoracic aorta
Mikkelsen, E. O., Thastrup, Ole & Christensen, Søren Brøgger, 1988, In: Pharmacology & Toxicology. 62, 1, p. 7-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of the Effects of Thapsigargin and BAY K 8644 on Spontaneous Mechanical Activity in Rat Portal Vein and Contractile Responses of Rat Cardiac Muscle
Mikkelsen, E. O., Poulsen, S. H. & Christensen, Søren Brøgger, Feb 1992, In: Pharmacology & Toxicology. 70, 2, p. 152-156 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland
Molander, M., Christensen, Søren Brøgger, Jaeger, A. K., Olsen, C. E. & Rønsted, Nina, 2012, In: Natural Product Research. 26, 1, p. 56-60 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release
Moldt, P., Andersen, W. K. & Christensen, Søren Brøgger, 1 Jun 1988, In: Agents and Actions. 24, 1-2, p. 35-39 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new sesquiterpene from laserpitium latifolium
Moldt, P., Smitt, U. W. & Christensen, Søren Brøgger, 1 Sep 1987, In: Journal of Natural Products. 50, 5, p. 974-975 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A
Nadelmann, L., Tjornelund, J., Hansen, S. H., Cornett, Claus, Sidelmann, U. G., Braumann, U., Christensen, E. & Christensen, Søren Brøgger, 1997, In: Xenobiotica. 27, 7, p. 667-680 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proacaciberin, A cyanogenic glycoside from Acacia sieberiana var. Woodii
Nartey, F., Brimer, L. & Christensen, Søren Brøgger, 1981, In: Phytochemistry. 20, 6, p. 1311-1314 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.
Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, Søren Brøgger, 2 Apr 2017. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Direct difluoromethylation of heterocycles using difluoroacetic acid
Nielsen, J., Truong Thanh Tung & Christensen, Søren Brøgger, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives
Nielsen, J., Christensen, Søren Brøgger & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.Research output: Contribution to journal › Conference article › Research › peer-review
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Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities
Nielsen, S. F., Kharazmi, A. & Christensen, Søren Brøgger, 1998, In: Bioorganic & Medicinal Chemistry. 6, 7, p. 937-45 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of antiparasitic licorice chalcones
Nielsen, S. F., Chen, M., Theander, Thor Grundtvig, Kharazmi, A. & Christensen, Søren Brøgger, 1995, In: Bioorganic & Medicinal Chemistry Letters. 5, p. 449-452 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12
Nielsen, S. F., Thastrup, Ole, Pedersen, R., Olsen, C. E. & Christensen, Søren Brøgger, 1995, In: Journal of Medicinal Chemistry. 38, 2, p. 272-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of thapsigargin
Nielsen, S. F., Andersen, A., Olsen, C. E., Treimann, M., Thastrup, Ole & Christensen, Søren Brøgger, 1 Dec 1993, In: Planta Medica. 59, 7 SUPPL., p. A678-A679Research output: Contribution to journal › Journal article › Research › peer-review
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The potencies of thapsigargin and analogues as activators of rat peritoneal mast cells
Norup, E., Smitt, U. W. & Christensen, Søren Brøgger, 1 Jan 1986, In: Planta Medica. NO. 4, p. 251-255 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages
Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Christensen, Søren Brøgger & Sugimura, T., Jul 1988, In: British Journal of Pharmacology. 94, 3, p. 917-923 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter
Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Sugimura, T. & Christensen, Søren Brøgger, 1 Jun 1987, In: Journal of Cancer Research and Clinical Oncology. 113, 4, p. 319-324 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters
Ohuchi, K., Hirasawa, N., Takahashi, C., Watanabe, M., Tsurufuji, S., Fujiki, H., Suganuma, M., Hakii, H., Sugimura, T. & Christensen, Søren Brøgger, 16 Jun 1986, In: BBA - Molecular Cell Research. 887, 1, p. 94-99 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx
Oketch-Rabah, H. A., Lemmich, E., Dossaji, S. F., Theander, Thor Grundtvig, Olsen, C. E., Cornett, Claus, Kharazmi, A. & Christensen, Søren Brøgger, 1997, In: Journal of Natural Products. 60, 5, p. 458-61 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx
Oketch-Rabah, H. A., Christensen, Søren Brøgger, Frydenvang, Karla Andrea, Dossaji, S. F., Theander, Thor Grundtvig, Cornett, Claus, Watkins, W. M., Kharazmi, A. & Lemmich, E., 1998, In: Planta Medica. 64, 6, p. 559-62 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation of the MAO-inhibitor naringenin from Mentha aquatica L
Olsen, H. T., Stafford, G. I., van Staden, J., Christensen, Søren Brøgger & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 117, 3, p. 500-502Research output: Contribution to journal › Journal article › Research › peer-review
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Are we ready for back-to-nature crop breeding?
Palmgren, Michael, Edenbrandt, A. K., Vedel, S. E., Andersen, M. M., Landes, X., Østerberg, J. T., Falhof, J., Olsen, L. I., Christensen, Søren Brøgger, Sandøe, Peter, Gamborg, Christian, Kappel, Klemens, Thorsen, Bo Jellesmark & Pagh-Rasmussen, Peter, 2015, In: Trends in Plant Science. 20, 3, p. 155-164 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioassay-guided identification and isolation of anticancer components in Hypholoma fasciculare extract
Pang, W. S. K., Chen, M., Zhai, L. & Christensen, Søren Brøgger, 2008.Research output: Contribution to conference › Poster › Research
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Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase
Paulsen, E. S., Villadsen, J., Tenori, E., Liu, Huizhen, Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation of tow high-polar fractions from 'Banlangen', root of isatis tinctoria L. and its activity
Qin, Q., He, H. P., Christensen, Søren Brøgger, Rasmussen, H. B., Kharazmi, A. & Chen, M., 1 Jan 2001, In: Chinese Pharmacological Bulletin. 17, 6, p. 714-715 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Absolute configuration and antiprotozoal activity of minquartynoic acid
Rasmussen, H. B., Christensen, Søren Brøgger, Kvist, L. P., Kharazmi, A. & Huansi, A. G., 2000, In: Journal of Natural Products. 63, 9, p. 1295-6 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa
Rasmussen, H. B., Christensen, Søren Brøgger, Kvist, L. P. & Karazmi, A., 22 Jun 2000, In: Planta Medica. 66, 4, p. 396-398 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L
Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1978, In: Acta Pharmaceutica Suecica. 15, 2, p. 133-140 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and biological activity of sesquiterpene lactones from Thapsia species and of analogue derivatives
Rasmussen, U., Christensen, Søren Brøgger & Patkar, S. A., 1 Jan 1982, In: Planta Medica. 45, 3, p. P23Research output: Contribution to journal › Journal article › Research › peer-review
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Phytochemical and pharmacological investigations of the genus Thapsia (Apiaceae)
Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1978, In: PLANTA MED.. 33, 3, p. 301-302 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phytochemistry of the genus Thapsia
Rasmussen, U., Christensen, Søren Brøgger & Sandberg, F., 1 Jan 1981, In: Planta Medica. 43, 4, p. 336-341 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
Rubal, J. J., Moreno-Dorado, F. J., Guerra, F. M., Jorge, Z. D., Galán, M. D. C., Salido, G. M., Christensen, Søren Brøgger, Søhoel, H. & Massanet, G. M., 2010, In: Planta Medica. 76, 3, p. 284-290Research output: Contribution to journal › Journal article › Research › peer-review
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Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida
Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Rønsted, Nina, Symonds, M. R. E., Birkholm, T., Christensen, Søren Brøgger, Meerow, A. W., Schmidt, M. M., Mølgaard, Per, Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.Research output: Contribution to journal › Journal article › Research › peer-review
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Planternes slægtskab som skattekort til nye lægemidler
Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21Research output: Contribution to journal › Journal article › Communication
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Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)
Saaby, Lasse, Jäger, A., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Aug 2010, In: Planta Medica. 76, 12, p. 1171Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)
Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS
Scharff, O., Foder, B., Thastrup, Ole, Hofmann, B., Møller, J., Ryder, L. P., Jacobsen, K. D., Langhoff, E., Dickmeiss, E. & Christensen, Søren Brøgger, 1988, In: BBA General Subjects. 972, 3, p. 257-64 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response
Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673Research output: Contribution to journal › Journal article › Research › peer-review
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S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis
Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of Medicinal Plants from Chile
Simonsen, H. T., Guzman, A., Adsersen, A., Christensen, Søren Brøgger & Mølgaard, Per, 2008.Research output: Contribution to conference › Conference abstract for conference › Research
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Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis
Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase
Singh, P., Mhaka, A. M., Christensen, Søren Brøgger, Gray, J. J., Denmeade, S. R. & Isaacs, J. T., 21 Apr 2005, In: Journal of Medicinal Chemistry. 48, 8, p. 3005-3014 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida
Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars, Kharazmi, A., Nkrumah, F. K. & Christensen, Søren Brøgger, 1999, In: Planta Medica. 65, 3, p. 259-61 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alkamides from Phyllanthus fraternus
Sittie, A. A., Lemmich, E., Olsen, C. E., Hviid, Lars & Christensen, Søren Brøgger, 1998, In: Planta Medica. 64, 2, p. 192-3 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carroll rearrangement to construct the norneolignan skeleton
Skytte, D. M., Rasmussen, H. B. & Christensen, Søren Brøgger, 2008, In: Natural Product Research. 22, 2, p. 116-123Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase
Skytte, D. M., Møller, J. V., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M., Olsen, C. E. & Christensen, Søren Brøgger, 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5634-5646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NEW PROAZULENE GUAIANOLIDES FROM THAPSIA-VILLOSA
Smitt, U. W., Cornett, Claus, Andersen, A., Christensen, Søren Brøgger & Avato, P., 1990, In: Journal of Natural Products. 53, 6, p. 1479-1484 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HYDROINDENE SESQUITERPENES FROM THAPSIA-VILLOSA
Smitt, U. W., Cornett, Claus, Norup, E. & Christensen, Søren Brøgger, 1990, In: Phytochemistry. 29, 3, p. 873-875 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300951
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The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Research output: Contribution to journal › Journal article › Research › peer-review
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Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Research output: Contribution to journal › Journal article › Research › peer-review
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306
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Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Research output: Contribution to journal › Journal article › Research › peer-review
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