Comparison of the action of calcium antagonists on basophil histamine release

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Comparison of the action of calcium antagonists on basophil histamine release. / Bindslev Jensen, C; Clementsen, P; Stahl Skov, P; Svendsen, U G; Thastrup, Ole; Norn, S.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 42, No. 6, 1987, p. 441-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bindslev Jensen, C, Clementsen, P, Stahl Skov, P, Svendsen, UG, Thastrup, O & Norn, S 1987, 'Comparison of the action of calcium antagonists on basophil histamine release', Allergy: European Journal of Allergy and Clinical Immunology, vol. 42, no. 6, pp. 441-6.

APA

Bindslev Jensen, C., Clementsen, P., Stahl Skov, P., Svendsen, U. G., Thastrup, O., & Norn, S. (1987). Comparison of the action of calcium antagonists on basophil histamine release. Allergy: European Journal of Allergy and Clinical Immunology, 42(6), 441-6.

Vancouver

Bindslev Jensen C, Clementsen P, Stahl Skov P, Svendsen UG, Thastrup O, Norn S. Comparison of the action of calcium antagonists on basophil histamine release. Allergy: European Journal of Allergy and Clinical Immunology. 1987;42(6):441-6.

Author

Bindslev Jensen, C ; Clementsen, P ; Stahl Skov, P ; Svendsen, U G ; Thastrup, Ole ; Norn, S. / Comparison of the action of calcium antagonists on basophil histamine release. In: Allergy: European Journal of Allergy and Clinical Immunology. 1987 ; Vol. 42, No. 6. pp. 441-6.

Bibtex

@article{4fa7948e9e6d46839881f58a3906d39e,
title = "Comparison of the action of calcium antagonists on basophil histamine release",
abstract = "The inhibitory capacity of calcium antagonists on basophil histamine release was examined in allergic patients and in controls. All dihydropyridines tested (nifedipine, nimodipine, nitrendipine, nicardipine, felodipine) dose-dependently inhibited anti-IgE- and A23187-induced release with an order of potency of felodipine greater than nicardipine greater than nifedipine = nimodipine = nitrendipine. Only the inhibition induced by felodipine and nicardipine on anti-IgE-induced release could be counteracted by increasing extracellular calcium. Diltiazem, not belonging to the dihydropyridines, was a weak inhibitor. A combination of felodipine and verapamil in low concentrations exerted a synergistic inhibitory effect on histamine release, whereas this was not the case with other combinations of antagonists. The results suggest differences in the mode of action of the 1.4-dihydropyridines. This might be of significance in the search for calcium antagonists suitable in the treatment of allergic diseases.",
keywords = "Antibodies, Anti-Idiotypic, Basophils, Calcium Channel Blockers, Histamine Release, Humans, Hypersensitivity, Immunoglobulin E, Ion Channels",
author = "{Bindslev Jensen}, C and P Clementsen and {Stahl Skov}, P and Svendsen, {U G} and Ole Thastrup and S Norn",
year = "1987",
language = "English",
volume = "42",
pages = "441--6",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "6",

}

RIS

TY - JOUR

T1 - Comparison of the action of calcium antagonists on basophil histamine release

AU - Bindslev Jensen, C

AU - Clementsen, P

AU - Stahl Skov, P

AU - Svendsen, U G

AU - Thastrup, Ole

AU - Norn, S

PY - 1987

Y1 - 1987

N2 - The inhibitory capacity of calcium antagonists on basophil histamine release was examined in allergic patients and in controls. All dihydropyridines tested (nifedipine, nimodipine, nitrendipine, nicardipine, felodipine) dose-dependently inhibited anti-IgE- and A23187-induced release with an order of potency of felodipine greater than nicardipine greater than nifedipine = nimodipine = nitrendipine. Only the inhibition induced by felodipine and nicardipine on anti-IgE-induced release could be counteracted by increasing extracellular calcium. Diltiazem, not belonging to the dihydropyridines, was a weak inhibitor. A combination of felodipine and verapamil in low concentrations exerted a synergistic inhibitory effect on histamine release, whereas this was not the case with other combinations of antagonists. The results suggest differences in the mode of action of the 1.4-dihydropyridines. This might be of significance in the search for calcium antagonists suitable in the treatment of allergic diseases.

AB - The inhibitory capacity of calcium antagonists on basophil histamine release was examined in allergic patients and in controls. All dihydropyridines tested (nifedipine, nimodipine, nitrendipine, nicardipine, felodipine) dose-dependently inhibited anti-IgE- and A23187-induced release with an order of potency of felodipine greater than nicardipine greater than nifedipine = nimodipine = nitrendipine. Only the inhibition induced by felodipine and nicardipine on anti-IgE-induced release could be counteracted by increasing extracellular calcium. Diltiazem, not belonging to the dihydropyridines, was a weak inhibitor. A combination of felodipine and verapamil in low concentrations exerted a synergistic inhibitory effect on histamine release, whereas this was not the case with other combinations of antagonists. The results suggest differences in the mode of action of the 1.4-dihydropyridines. This might be of significance in the search for calcium antagonists suitable in the treatment of allergic diseases.

KW - Antibodies, Anti-Idiotypic

KW - Basophils

KW - Calcium Channel Blockers

KW - Histamine Release

KW - Humans

KW - Hypersensitivity

KW - Immunoglobulin E

KW - Ion Channels

M3 - Journal article

C2 - 2444127

VL - 42

SP - 441

EP - 446

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 6

ER -

ID: 43350385