Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer. / Stampe, Helene; Jakobsen, Kathrine Kronberg; Tvedskov, Jesper Filtenborg; Wessel, Irene; Kiss, Katalin; Friborg, Jeppe; Andersen, Amanda Oester; Grønhøj, Christian; von Buchwald, Christian; Christensen, Anders.
In: Otolaryngology - Head and Neck Surgery (United States), Vol. 169, No. 2, 2023, p. 276-285.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer
AU - Stampe, Helene
AU - Jakobsen, Kathrine Kronberg
AU - Tvedskov, Jesper Filtenborg
AU - Wessel, Irene
AU - Kiss, Katalin
AU - Friborg, Jeppe
AU - Andersen, Amanda Oester
AU - Grønhøj, Christian
AU - von Buchwald, Christian
AU - Christensen, Anders
N1 - Publisher Copyright: © American Academy of Otolaryngology–Head and Neck Surgery Foundation 2022.
PY - 2023
Y1 - 2023
N2 - Objectives: To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature. Study Design: Retrospective register-based study. Setting: Copenhagen Oral Cavity Squamous Cell Carcinoma database. Methods: Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival were determined by Kaplan-Meier survival curves. Results: In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve determined thresholds of LNY, LND, and pN to be 21 nodes, 5%, and 3 metastases, respectively. The 5-year overall survival was 52% for patients with LNY ≥21 vs 38% for patients with LNY <21 (hazard ratio [HR], 1.49; 95% CI, 1.05-2.11; P <.05), 60% for patients with LND ≤5% vs 38% for patients with LND >6% (HR, 1.63; 95% CI, 1.03-2.57; P <.05), and 43% for patients with pN <3 vs 26% for patients with pN ≥3 (HR, 1.40; 95% CI, 1.04-2.15; P <.05). Conclusions: Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical quality indicator. LND may have implications as a tool in cancer staging and treatment planning.
AB - Objectives: To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature. Study Design: Retrospective register-based study. Setting: Copenhagen Oral Cavity Squamous Cell Carcinoma database. Methods: Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival were determined by Kaplan-Meier survival curves. Results: In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve determined thresholds of LNY, LND, and pN to be 21 nodes, 5%, and 3 metastases, respectively. The 5-year overall survival was 52% for patients with LNY ≥21 vs 38% for patients with LNY <21 (hazard ratio [HR], 1.49; 95% CI, 1.05-2.11; P <.05), 60% for patients with LND ≤5% vs 38% for patients with LND >6% (HR, 1.63; 95% CI, 1.03-2.57; P <.05), and 43% for patients with pN <3 vs 26% for patients with pN ≥3 (HR, 1.40; 95% CI, 1.04-2.15; P <.05). Conclusions: Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical quality indicator. LND may have implications as a tool in cancer staging and treatment planning.
KW - lymph node density
KW - lymph node yield
KW - oral squamous cell carcinoma
KW - pN
KW - prognostic value
U2 - 10.1177/01945998221123927
DO - 10.1177/01945998221123927
M3 - Journal article
C2 - 36066971
AN - SCOPUS:85138415953
VL - 169
SP - 276
EP - 285
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
SN - 0194-5998
IS - 2
ER -
ID: 325922698