Morten Grunnet
Affiliate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2001
- Published
Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels
Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a novel voltage-gated Na+ channel rNav 1.5a in the rat hippocampal progenitor stem cell line HiB5
Korsgaard, M., Grunnet, Morten, Christophersen, P., Ahring, P. K. & Olesen, Søren-Peter, 2001, In: Pflügers Archiv: European Journal of Physiology. 443, p. 18-30Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological modulation of SK3 channels
Grunnet, Morten, Jespersen, Thomas, Angelo, K., Frøkjær-Jensen, Christian, Klærke, Dan Arne, Olesen, Poul & Jensen, B. S., 1 Jun 2001, In: Neuropharmacology. 40, 7, p. 879-887 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
KCNE4 is an inhibitory subunit to the KCNQ1 channel.
Grunnet, Morten, Jespersen, Thomas, Rasmussen, Hanne Borger, Ljungstrøm, T., Jorgensen, N. K., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Journal of Physiology. 542, Pt 1, p. 119-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.
Angelo, K., Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, Søren-Peter, 2002, In: Biophysical Journal. 83, 4, p. 1997-2006 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.
Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes
Jespersen, Thomas, Grunnet, Morten, Angelo, K., Klærke, Dan Arne & Olesen, Poul, 1 Mar 2002, In: BioTechniques. 32, 3, p. 536-8, 540Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.
Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.
Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis.
Nørremølle, Anne, Grunnet, Morten, Hasholt, Lis Frydenreich & Sørensen, S. A., 2003, In: Journal of Neuroscience Research. 71, 1, p. 132-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of two new dominant ClC-1 channel mutations associated with myotonia.
Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.
Ljungstrom, T., Grunnet, Morten, Jensen, B. S. & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 6, p. 684-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.
Grunnet, Morten, Rasmussen, H. B., Hay-Schmidt, Anders, Rosenstierne, M., Klærke, Dan Arne, Olesen, Søren-Peter & Jespersen, Thomas, 2003, In: Biophysical Journal. 85, 3, p. 1525-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ1 channels sense small changes in cell volume.
Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.
Hay-Schmidt, Anders, Grunnet, Morten, Abrahamse, S. L., Knaus, H. & Klærke, Dan Arne, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 61-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological investigation of the role of ion channels in salivary secretion.
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Rasmussen, Hanne Borger, Olesen, Søren-Peter & Jorgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological activity of a thioether analogue of conotoxin G1.
Bondebjerg, J., Grunnet, Morten, Jespersen, Thomas & Meldal, Morten Peter, 2003, In: ChemBioChem. 4, 2-3, p. 186-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role og K+ and C1- channels in salivary secretion
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, p. 78-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia.
Grunnet, Morten, Rasmussen, Hanne Borger, Hay-Schmidt, Anders & Klærke, Dan Arne, 2003, In: BBA General Subjects. 1616, 1, p. 85-94 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.
Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.
Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brain.
Grunnet, Morten & Kaufmann, W. A., 2004, In: Journal of Biological Chemistry. 279, 35, p. 36445-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype.
Dunø, M., Colding-Jørgensen, E., Grunnet, Morten, Jespersen, Thomas, Vissing, John & Schwartz, M., 2004, In: European Journal of Human Genetics. 12, 9, p. 738-43 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does KCNE5 play a role in long QT syndrome?
Hofman-Bang, J., Jespersen, Thomas, Grunnet, Morten, Larsen, Lars Allan, Andersen, P. S., Kanters, Jørgen K., Kjeldsen, K. & Christiansen, M., 2004, In: Clinica Chimica Acta. 345, 1-2, p. 49-53 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog
Grunnet, Morten, Jespersen, Thomas & Perrier, Jean-Francois Marie, 2004, In: Journal of Neuroscience Research. 78, p. 845-854Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.
Grunnet, Morten, Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, Søren-Peter & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.
Callø, Kirstine, Elmedyb, P., Olesen, Søren-Peter, Jorgensen, N. K. & Grunnet, Morten, 2005, In: Biophysical Journal. 89, 3, p. 2159-69 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantification and distribution of big conductance Ca2+-activated K+ channels in kidney epithelia.
Grunnet, Morten, Hay-Schmidt, Anders & Klærke, Dan Arne, 2005, In: BBA General Subjects. 1714, 2, p. 114-24 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNQ1 potassium channel: from gene to physiological function.
Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.
Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]
Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
Bøttger, P., Hede, S. E., Grunnet, Morten, Høyer, B., Klærke, Dan Arne & Pedersen, L., 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C1377-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.
Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Activation of ERG2 potassium channels by the diphenylurea NS1643.
Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivation as a new regulatory mechanism for neuronal Kv7 channels.
Jensen, H. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Biophysical Journal. 92, 8, p. 2747-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.
Callø, Kirstine, Nielsen, Morten Schak, Grunnet, Morten, Schmitt, Nicole & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of ERG channels by XE991.
Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.
Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, Morten, Christiansen, M., Olesen, Søren-Peter & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 996-1002 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome
Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic effect of IKr activation in a cellular model of LQT3
Diness, Jonas Goldin, Hansen, R. S., Nissen, J. D., Jespersen, Thomas & Grunnet, Morten, 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function
Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.
Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 182570346
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Research output: Contribution to journal › Journal article › Research › peer-review
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345
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Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
286
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Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Research output: Contribution to journal › Journal article › Research › peer-review
Published