Christian Adam Olsen

Christian Adam Olsen

Professor

ORCID: 0000-0002-2953-8942

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  1. Published

    Zn2+-Dependent Histone Deacetylases in Plants: Structure and Evolution

    Yruela, I., Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: Trends in Plant Science. 26, 7, p. 741-757

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

    Yan, D., Franzini, A., Pomicter, A. D., Halverson, B. J., Antelope, O., Mason, C. C., Ahmann, J. M., Senina, A. V., Vellore, N. A., Jones, C. L., Zabriskie, M. S., Than, H., Xiao, M. J., van Scoyk, A., Patel, A. B., Clair, P. M., Heaton, W. L., Owen, S. C., Andersen, J. L., Egbert, C. M. & 11 others, Reisz, J. A., D'Alessandro, A., Cox, J. E., Gantz, K. C., Redwine, H. M., Iyer, S. M., Khorashad, J. S., Rajabi, N., Olsen, Christian Adam, O'Hare, T. & Deininger, M. W., 2021, In: Cancer Discovery. 2, 3, p. 266-287

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  3. Published

    Functionalized Helical beta-Peptoids

    Wellhofer, I., Frydenvang, Karla Andrea, Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, Christian Adam, 5 Apr 2019, In: Journal of Organic Chemistry. 84, 7, p. 3762-3779

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Increasing the Functional Group Diversity in Helical beta-Peptoids: Achievement of Solvent- and pH-Dependent Folding

    Wellhofer, I., Beck, J., Frydenvang, Karla Andrea, Brase, S. & Olsen, Christian Adam, 2020, In: Journal of Organic Chemistry. 85, 16, p. 10466-10478 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    An azumamide C analogue without the zinc-binding functionality

    Villadsen, J. S., Kitir, B., Wich, K., Friis, T., Madsen, A. S. & Olsen, Christian Adam, 12 Aug 2014, In: MedChemComm. 5, p. 1849-1855

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A-E as Well as beta(2)- epi-Azumamide E and beta(3)-epi-Azumamide E

    Villadsen, J., Stephansen, H. M., Maolanon, A. R., Harris, Pernille & Olsen, Christian Adam, 22 Aug 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6512-6520

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

    Vickers, C. J., Olsen, Christian Adam, Leman, L. J. & Ghadiri, M. R., Jun 2012, In: ACS Medicinal Chemistry Letters. 3, 6, p. 505-508

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Conformationally rigid histone deacetylase inhibitors correct DF508-CFTR protein function

    Vickers, C. J., Olsen, Christian Adam, Hutt, D. M., Montero, A., Leman, L. J., Maryanoff, B. E., Balch, W. E. & Ghadiri, M. R., 28 Aug 2011, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 242

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras

    Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase

    Troelsen, K. S., Bæk, M., Nielsen, A. L., Madsen, A. S., Rajabi, N. & Olsen, Christian Adam, 2021, In: RSC Chemical Biology. 2, p. 627-635

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

    Tan, M., Peng, C., Anderson, K. A., Xie, Z., Chhoy, P., Dai, L., Park, J., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G. R., Green, M. F., Madsen, A. S., Schmiesing, J., Peterson, B. S., Xu, G., Ilkayeva, O. R., Muehlbauer, M. J., Braulke, T. & 8 others, Mühlhausen, C., Backos, D. S., Olsen, Christian Adam, McGuire, P. J., Pletcher, S. D., Lombard, D. B., Hirschey, M. D. & Zhao, Y., 1 Apr 2014, In: Cell Metabolism. 19, 4, p. 605–617

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy

    Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Dimeric Building Blocks for Solid-Phase Synthesis of α-Peptide-β-Peptoid Chimeras

    Seigan, G. B., Vedel, L., Matthias, W., Jaroszewski, J. W., Olsen, Christian Adam & Franzyk, Henrik, 2008, In: Synthesis. 2008, 15, p. 2381-2390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

    Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants

    Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

    Rajabi, N., Auth, M., Troelsen, K. R., Pannek, M., Bhatt, D., Fontenas, M., Hirschey, M., Steegborn, C., Madsen, A. S. & Olsen, Christian Adam, 20 Nov 2017, In: Angewandte Chemie, Int. Ed.. 56, 47, p. 14836-14841

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Targeting Sirtuins: Substrate Specificity and Inhibitor Design

    Rajabi, N., Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 Feb 2018, Progress in Molecular Biology and Translational Science: Sirtuins in Health and Disease. Elsevier, p. 25-69 (Progress in Molecular Biology and Translational Science, Vol. 154).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  18. Published

    Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme**

    Rajabi, N., Hansen, T. N., Nielsen, A. L., Nguyen, H. T., Bæk, M., Bolding, J. E., Bahlke, O., Petersen, S. E. G., Bartling, Christian Reinhard Otto, Strømgaard, Kristian & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 22, 9 p., e202115805.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Dethioacylation by sirtuins 1–3: Considerations for drug design using mechanism-based sirtuin inhibition

    Rajabi, N., Nielsen, A. L. & Olsen, Christian Adam, 2020, In: A C S Medicinal Chemistry Letters. 11, 10, p. 1886-1892

    Research output: Contribution to journal › Letter › Research › peer-review

  20. Published

    Modular total synthesis of lamellarin D

    Pla, D., Marchal, A., Olsen, Christian Adam, Albericio, F. & Álvarez, M., 20 Sep 2005, In: Journal of Organic Chemistry. 70, 20, p. 8231-8234 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid lamellarin D

    Pla, D., Marchal, A., Olsen, Christian Adam, Francesch, A., Cuevas, C., Albericio, F. & Alvarez, M., 1 Jun 2006, In: Journal of Medicinal Chemistry. 49, 11, p. 3257-3268 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Effect of co-inhabiting coagulase negative staphylococci on S. Aureus agr quorum sensing, host factor binding, and biofilm formation

    Peng, P., Baldry, M., Gless, B. H., Bojer, Martin Saxtorph, Espinosa-Gongora, C., Baig, S. J., Andersen, P. S., Olsen, Christian Adam & Ingmer, Hanne, 2019, In: Frontiers in Microbiology. 10, SEP, 14 p., 2212.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

    Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    An Update on Lysine Deacylases Targeting the Expanding "Acylome"

    Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 434-437 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic alpha(3)beta-Tetrapeptides

    Olsen, Christian Adam & Ghadiri, M. R., 10 Dec 2009, In: Journal of Medicinal Chemistry. 52, 23, p. 7836-7846

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Philanthotoxin Analogues Containing Novel Polyamine Moieties

    Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2002.

    Research output: Contribution to conference › Poster › Research

  27. Published

    New Efficient SN2 Protocol for the Synthesis of Polyamine Toxins on Solid Phase

    Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2003.

    Research output: Contribution to conference › Poster › Research

  28. Published

    Macrocyclic Peptoid-Peptide Hybrids as Inhibitors of Class I Histone Deacetylases

    Olsen, Christian Adam, Montero, A., Leman, L. J. & Ghadiri, M. R., Sep 2012, In: ACS Medicinal Chemistry Letters. 3, 9, p. 749-753

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    New Linker Strategies in SPS of Neuroactive Wasp Toxin Analogues

    Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2005.

    Research output: Contribution to conference › Poster › Research

  31. Published

    Expansion of the Lysine Acylation Landscape

    Olsen, Christian Adam, 2012, In: Angewandte Chemie International Edition. 51, 16, p. 3755-3756

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker

    Olsen, Christian Adam, Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Tetrahedron Letters. 48, 3, p. 405-408

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Nanomolær inhibering med hvepsetoksinanaloger – syntese og elektrofysiologi

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Dansk Kemi. 87, p. 23-26 4 p.

    Research output: Contribution to journal › Journal article › Communication

  34. Published

    Kunstige forsvarspeptider

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Lægemiddelforskning. p. 18-19 2 p.

    Research output: Contribution to journal › Journal article › Communication

  35. Published

    Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins

    Olsen, Christian Adam, Witt, M., Hansen, S. H., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Tetrahedron. 61, p. 6046-6055 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Aziridines in parallel- and solid-phase synthesis

    Olsen, Christian Adam, Bonke, G., Vedel, L., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: European Journal of Organic Chemistry. 2007, 11, p. 1717-1724

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    Hurtige genveje til nye lægemidler

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2003, In: Lægemiddelforskning. 2003, p. 8-9 2 p.

    Research output: Contribution to journal › Journal article › Communication

  38. Published

    Solid-phase peptide synthesis and circular dichroism study of chiral ß-peptoid homooligomers

    Olsen, Christian Adam, Lambert, M., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2008, In: Amino Acids. 34, 3, p. 465-471

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    α-Peptide/ß-Peptoid Chimeras

    Olsen, Christian Adam, Bonke, G., Vedel, L., Adsersen, A., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: Organic Letters. 9, 8, p. 1549–1552 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation

    Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. p. 473-476 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The Choice of Phosphane Reagent in Fukuyama-Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of Philanthotoxins

    Olsen, Christian Adam, Jørgensen, M. R., Witt, M., Mellor, I. R., Usherwood, P. N. R., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: European Journal of Organic Chemistry. p. 3288-3299 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Peptoid-Peptide hybrid backbone architectures

    Olsen, Christian Adam, 25 Jan 2010, In: ChemBioChem. 11, 2, p. 152-160

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Profiling of Substrates for Zinc-dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

    Olsen, Christian Adam & Madsen, A., 2012, In: Angewandte Chemie International Edition. 51, 36, p. 9083-9087

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    N-Alkylation Reactions and Indirect Formation of Amino Functionalities in Solid-Phase Synthesis

    Olsen, Christian Adam, Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Synthesis. p. 2631-2653 23 p.

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

    Olsen, Christian Adam, Parera, N., Albericio, F. & Álvarez, M., 21 Mar 2005, In: Tetrahedron Letters. 46, 12, p. 2041-2044 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  47. Published

    β-peptoid “Foldamers”-Why the additional methylene unit?

    Olsen, Christian Adam, 1 Jan 2011, In: Biopolymers. 96, 5, p. 561-566 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

    Olsen, Christian Adam, Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Organic Letters. 7, 9, p. 1703-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Solid-phase polyamine synthesis using piperazine and piperidine building blocks

    Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2003, In: Organic Letters. 5, 22, p. 4183-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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